Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II

Craig H Warden, Catherine C. Hedrick, Jian Hua Qiao, Lawrence W. Castellani, Aldons J. Lusis

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Abstract

Concentrations of plasma high density lipoprotein (HDL) are inversely correlated with atherosclerotic coronary artery disease. The two most abundant protein constituents of HDL are apolipoproteins A-I and A-II (apoA-I and apoA-II). ApoA-I is required for assembly of HDL and, when overexpressed in transgenic mice, confers resistance to early atherosclerosis. The present studies reveal that transgenic mice that overexpress mouse apoA-II had elevated HDL-cholesterol concentrations but, nevertheless, exhibited increased atherosclerotic lesion development as compared to normal mice. The HDL in the transgenic mice was larger and had an increased ratio of apoA-II to apoA-I. Thus, both the composition and amount of HDL appear to be important determinants of atherosclerosis.

Original languageEnglish (US)
Pages (from-to)469-472
Number of pages4
JournalScience
Volume261
Issue number5120
StatePublished - Jul 23 1993

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Apolipoprotein A-II
HDL Lipoproteins
Transgenic Mice
Apolipoprotein A-I
Atherosclerosis
HDL Cholesterol
Coronary Artery Disease
Proteins

ASJC Scopus subject areas

  • General

Cite this

Warden, C. H., Hedrick, C. C., Qiao, J. H., Castellani, L. W., & Lusis, A. J. (1993). Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II. Science, 261(5120), 469-472.

Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II. / Warden, Craig H; Hedrick, Catherine C.; Qiao, Jian Hua; Castellani, Lawrence W.; Lusis, Aldons J.

In: Science, Vol. 261, No. 5120, 23.07.1993, p. 469-472.

Research output: Contribution to journalArticle

Warden, CH, Hedrick, CC, Qiao, JH, Castellani, LW & Lusis, AJ 1993, 'Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II', Science, vol. 261, no. 5120, pp. 469-472.
Warden CH, Hedrick CC, Qiao JH, Castellani LW, Lusis AJ. Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II. Science. 1993 Jul 23;261(5120):469-472.
Warden, Craig H ; Hedrick, Catherine C. ; Qiao, Jian Hua ; Castellani, Lawrence W. ; Lusis, Aldons J. / Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II. In: Science. 1993 ; Vol. 261, No. 5120. pp. 469-472.
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