Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II

Craig H Warden, Catherine C. Hedrick, Jian Hua Qiao, Lawrence W. Castellani, Aldons J. Lusis

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Abstract

Concentrations of plasma high density lipoprotein (HDL) are inversely correlated with atherosclerotic coronary artery disease. The two most abundant protein constituents of HDL are apolipoproteins A-I and A-II (apoA-I and apoA-II). ApoA-I is required for assembly of HDL and, when overexpressed in transgenic mice, confers resistance to early atherosclerosis. The present studies reveal that transgenic mice that overexpress mouse apoA-II had elevated HDL-cholesterol concentrations but, nevertheless, exhibited increased atherosclerotic lesion development as compared to normal mice. The HDL in the transgenic mice was larger and had an increased ratio of apoA-II to apoA-I. Thus, both the composition and amount of HDL appear to be important determinants of atherosclerosis.

Original languageEnglish (US)
Pages (from-to)469-472
Number of pages4
JournalScience
Volume261
Issue number5120
StatePublished - Jul 23 1993

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Warden, C. H., Hedrick, C. C., Qiao, J. H., Castellani, L. W., & Lusis, A. J. (1993). Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II. Science, 261(5120), 469-472.