At the crossroads: Mucosal immunology of the larynx

S. L. Thibeault, L. Rees, L. Pazmany, M. A. Birchall

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The larynx sits at the crossroads between gastrointestinal and respiratory tracts. Besides its intrinsic importance in breathing, swallowing and voice production, the larynx is also exposed to unique immunological challenges. Given the propensity of chronic inflammatory conditions such as chronic laryngitis, which affects up to 20% of Western populations, it is surprising that our understanding of the immunology of this organ remains relatively limited. Recent work on the immunological architecture of the laryngeal mucosa, and its changes that result from external challenges and inflammatory conditions, provided valuable insight into the fascinating immunology of this organ. The lessons learnt from these investigations may go beyond devising improved therapy for chronic laryngeal inflammation. Establishing whether and how the laryngeal mucosa may be involved in the modulation of wider mucosal responses may provide novel routes to the treatment of inflammatory diseases of the respiratory and alimentary tracts such as asthma and inflammatory bowel disease.

Original languageEnglish (US)
Pages (from-to)122-128
Number of pages7
JournalMucosal Immunology
Volume2
Issue number2
DOIs
StatePublished - 2009
Externally publishedYes

Fingerprint

Laryngeal Mucosa
Larynx
Allergy and Immunology
Laryngitis
Respiratory Tract Diseases
Deglutition
Inflammatory Bowel Diseases
Respiratory System
Gastrointestinal Tract
Respiration
Asthma
Inflammation
Population
Therapeutics

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Thibeault, S. L., Rees, L., Pazmany, L., & Birchall, M. A. (2009). At the crossroads: Mucosal immunology of the larynx. Mucosal Immunology, 2(2), 122-128. https://doi.org/10.1038/mi.2008.82

At the crossroads : Mucosal immunology of the larynx. / Thibeault, S. L.; Rees, L.; Pazmany, L.; Birchall, M. A.

In: Mucosal Immunology, Vol. 2, No. 2, 2009, p. 122-128.

Research output: Contribution to journalArticle

Thibeault, SL, Rees, L, Pazmany, L & Birchall, MA 2009, 'At the crossroads: Mucosal immunology of the larynx', Mucosal Immunology, vol. 2, no. 2, pp. 122-128. https://doi.org/10.1038/mi.2008.82
Thibeault SL, Rees L, Pazmany L, Birchall MA. At the crossroads: Mucosal immunology of the larynx. Mucosal Immunology. 2009;2(2):122-128. https://doi.org/10.1038/mi.2008.82
Thibeault, S. L. ; Rees, L. ; Pazmany, L. ; Birchall, M. A. / At the crossroads : Mucosal immunology of the larynx. In: Mucosal Immunology. 2009 ; Vol. 2, No. 2. pp. 122-128.
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