Abstract
Osteosarcoma is the most common primary malignancy of bone. Most cases are sporadic without a known genetic or environmental cause. Heritable genetic predisposition syndromes are associated with a small percentage of osteosarcomas. Study of these rare disorders has provided insight into the molecular pathogenesis of osteosarcoma. Screening of at-risk families and surveillance of affected individuals for these syndromes may permit earlier diagnosis and more effective treatment of osteosarcoma in these populations. This paper reviews the genetic and clinical features of the known osteosarcoma predisposition syndromes.
| Original language | English (US) |
|---|---|
| Article number | 152382 |
| Journal | Sarcoma |
| Volume | 2012 |
| DOIs | |
| State | Published - Apr 18 2012 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Oncology
- Radiology Nuclear Medicine and imaging
Cite this
At-risk populations for osteosarcoma : The syndromes and beyond. / Calvert, George T.; Randall, R; Jones, Kevin B.; Cannon-Albright, Lisa; Lessnick, Stephen; Schiffman, Joshua D.
In: Sarcoma, Vol. 2012, 152382, 18.04.2012.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - At-risk populations for osteosarcoma
T2 - The syndromes and beyond
AU - Calvert, George T.
AU - Randall, R
AU - Jones, Kevin B.
AU - Cannon-Albright, Lisa
AU - Lessnick, Stephen
AU - Schiffman, Joshua D.
PY - 2012/4/18
Y1 - 2012/4/18
N2 - Osteosarcoma is the most common primary malignancy of bone. Most cases are sporadic without a known genetic or environmental cause. Heritable genetic predisposition syndromes are associated with a small percentage of osteosarcomas. Study of these rare disorders has provided insight into the molecular pathogenesis of osteosarcoma. Screening of at-risk families and surveillance of affected individuals for these syndromes may permit earlier diagnosis and more effective treatment of osteosarcoma in these populations. This paper reviews the genetic and clinical features of the known osteosarcoma predisposition syndromes.
AB - Osteosarcoma is the most common primary malignancy of bone. Most cases are sporadic without a known genetic or environmental cause. Heritable genetic predisposition syndromes are associated with a small percentage of osteosarcomas. Study of these rare disorders has provided insight into the molecular pathogenesis of osteosarcoma. Screening of at-risk families and surveillance of affected individuals for these syndromes may permit earlier diagnosis and more effective treatment of osteosarcoma in these populations. This paper reviews the genetic and clinical features of the known osteosarcoma predisposition syndromes.
UR - http://www.scopus.com/inward/record.url?scp=84859706280&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84859706280&partnerID=8YFLogxK
U2 - 10.1155/2012/152382
DO - 10.1155/2012/152382
M3 - Review article
C2 - 22550413
AN - SCOPUS:84859706280
VL - 2012
JO - Sarcoma
JF - Sarcoma
SN - 1357-714X
M1 - 152382
ER -