Asymmetric Synthesis of Homocitric Acid Lactone

Leslie A. Nickerson, Valerie Huynh, Edward I. Balmond, Stephen P. Cramer, Jared T. Shaw

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


A short, diastereoselective synthesis of homocitric acid lactone is described. The key step is a bioinspired aldol addition to set the stereogenic center in an intermediate that requires only modest oxidation state manipulation to complete the synthesis. This approach enables rapid generation of isotopomers in which carbon and hydrogen can be replaced by heavier nuclei at nearly every position.

Original languageEnglish (US)
Pages (from-to)11404-11408
Number of pages5
JournalJournal of Organic Chemistry
Issue number22
StatePublished - Nov 18 2016

ASJC Scopus subject areas

  • Organic Chemistry


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