Asymmetric synthesis of diamine derivatives via sequential palladium and rhodium catalysis

Barry M. Trost, Sushant Malhotra, David Olson, Autumn Maruniak, J. Du Bois

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

The use of a bifunctional nitrogen nucleophile and an allyl carbonate starting material in successive enantioselective palladium- and diastereoselective rhodium-catalyzed reactions enables the rapid assembly of unique amino aziridine products. Further elaboration of these materials affords complex, stereodefined polyamine architectures, thus demonstrating the power of these combined methods for simplifying asymmetric C-N bond construction.

Original languageEnglish (US)
Pages (from-to)4190-4191
Number of pages2
JournalJournal of the American Chemical Society
Volume131
Issue number12
DOIs
StatePublished - Apr 1 2009
Externally publishedYes

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ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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