Asymmetric oscillation of adherent targeted ultrasound contrast agents

Shukui Zhao, Katherine W. Ferrara, Paul A. Dayton

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


With a lipid shell containing biotin, micron-sized bubbles bound to avidin on a porous and flexible cellulose boundary were insonified by ultrasound. The oscillation of these targeted microbubbles was observed by high-speed photography and compared to the oscillation of free-floating microbubbles. Adherent microbubbles were observed to oscillate asymmetrically in the plane normal to the boundary, and nearly symmetrically in the plane parallel to the boundary, with a significantly smaller maximum expansion in each dimension for bound than free bubbles. With sufficient transmitted pressure, a jet was produced traveling toward the boundary.

Original languageEnglish (US)
Article number134103
Pages (from-to)1-3
Number of pages3
JournalApplied Physics Letters
Issue number13
StatePublished - Sep 26 2005

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)


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