Asymmetric growth and development of the Xenopus laevis retina during metamorphosis is controlled by type III deiodinase

Nicholas Marsh-Armstrong, Haochu Huang, Benjamin F. Remo, Tong Tong Liu, Donald D. Brown

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

During the metamorphosis of the Xenopus laevis retina, thyroid hormone (TH) preferentially induces ventral ciliary marginal zone (CMZ) cells to both increase their proliferation and give rise to ipsilaterally projecting ganglion cells. Here we show that dorsal CMZ cells express type III deiodinase (D3), an enzyme that inactivates TH. The dorsal CMZ cells can be induced to proliferate if deiodinase activity is inhibited. D3 or dominant- negative thyroid hormone receptor transgenes inhibit both TH-induced proliferation of the ventral CMZ cells and the formation of the ipsilateral projection. Thus, the localized expression of D3 in the dorsal CMZ cells accounts for the asymmetric growth of the frog retina.

Original languageEnglish (US)
Pages (from-to)871-878
Number of pages8
JournalNeuron
Volume24
Issue number4
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

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Xenopus laevis
Growth and Development
Retina
Thyroid Hormones
Thyroid Hormone Receptors
Iodide Peroxidase
Transgenes
Ganglia
Anura
iodothyronine deiodinase type III
Enzymes
Growth

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Asymmetric growth and development of the Xenopus laevis retina during metamorphosis is controlled by type III deiodinase. / Marsh-Armstrong, Nicholas; Huang, Haochu; Remo, Benjamin F.; Liu, Tong Tong; Brown, Donald D.

In: Neuron, Vol. 24, No. 4, 01.01.1999, p. 871-878.

Research output: Contribution to journalArticle

Marsh-Armstrong, Nicholas ; Huang, Haochu ; Remo, Benjamin F. ; Liu, Tong Tong ; Brown, Donald D. / Asymmetric growth and development of the Xenopus laevis retina during metamorphosis is controlled by type III deiodinase. In: Neuron. 1999 ; Vol. 24, No. 4. pp. 871-878.
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