Astroglial proliferation and phenotype are modulated by neuronal plasma membrane

Gen Sobue, David E Pleasure

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

The rate of proliferation of rat astroglia cultured in a serum-free medium, estimated by tritiated thymidine radioautography, was diminished by more than 50% by addition of rat central nervous system axolemmal fragments to the culture medium. Addition of the axolemmal fragments also induced a phenotypic alteration of the cultured astroglia, from cells of irregular shape containing a fine meshwork of intracytoplasmic glial fibrils to star-shaped cells with thicker, cable-like glial fibrils.

Original languageEnglish (US)
Pages (from-to)175-179
Number of pages5
JournalBrain Research
Volume324
Issue number1
DOIs
StatePublished - Dec 17 1984
Externally publishedYes

Keywords

  • astroglia
  • axolemma
  • glial fibrillary acidic protein
  • neurons

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Astroglial proliferation and phenotype are modulated by neuronal plasma membrane'. Together they form a unique fingerprint.

  • Cite this