Astroglial proliferation and phenotype are modulated by neuronal plasma membrane

Gen Sobue; David E Pleasure

doi:10.1016/0006-8993(84)90639-5

Astroglial proliferation and phenotype are modulated by neuronal plasma membrane

Gen Sobue, David E Pleasure

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

The rate of proliferation of rat astroglia cultured in a serum-free medium, estimated by tritiated thymidine radioautography, was diminished by more than 50% by addition of rat central nervous system axolemmal fragments to the culture medium. Addition of the axolemmal fragments also induced a phenotypic alteration of the cultured astroglia, from cells of irregular shape containing a fine meshwork of intracytoplasmic glial fibrils to star-shaped cells with thicker, cable-like glial fibrils.

Original language	English (US)
Pages (from-to)	175-179
Number of pages	5
Journal	Brain Research
Volume	324
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(84)90639-5
State	Published - Dec 17 1984
Externally published	Yes

Keywords

astroglia
axolemma
glial fibrillary acidic protein
neurons

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
Neuroscience(all)

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10.1016/0006-8993(84)90639-5

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abstract = "The rate of proliferation of rat astroglia cultured in a serum-free medium, estimated by tritiated thymidine radioautography, was diminished by more than 50% by addition of rat central nervous system axolemmal fragments to the culture medium. Addition of the axolemmal fragments also induced a phenotypic alteration of the cultured astroglia, from cells of irregular shape containing a fine meshwork of intracytoplasmic glial fibrils to star-shaped cells with thicker, cable-like glial fibrils.",

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AU - Pleasure, David E

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AB - The rate of proliferation of rat astroglia cultured in a serum-free medium, estimated by tritiated thymidine radioautography, was diminished by more than 50% by addition of rat central nervous system axolemmal fragments to the culture medium. Addition of the axolemmal fragments also induced a phenotypic alteration of the cultured astroglia, from cells of irregular shape containing a fine meshwork of intracytoplasmic glial fibrils to star-shaped cells with thicker, cable-like glial fibrils.

KW - astroglia

KW - axolemma

KW - glial fibrillary acidic protein

KW - neurons

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JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -

Astroglial proliferation and phenotype are modulated by neuronal plasma membrane

Abstract

Keywords

ASJC Scopus subject areas

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