Research output: Chapter in Book/Report/Conference proceedingChapter


Astroglia are the most numerous cells in the central nervous system (CNS). Acting individually and in gap junction-coupled networks, astroglia support and modulate neuronal activity by regulating the CNS extracellular milieu and microvasculature, and participate in CNS innate and adaptive immune surveillance mechanisms. Astroglial dysfunction can exacerbate, and in some instances, initiate, neurodegenerative diseases previously thought to have an exclusively neuron-autonomous pathogenesis.

Original languageEnglish (US)
Title of host publicationEncyclopedia of the Neurological Sciences
PublisherElsevier Inc.
Number of pages3
ISBN (Electronic)9780123851574
ISBN (Print)9780123851581
StatePublished - Jan 1 2014


  • Astroglia
  • Blood-brain barrier
  • Chemokines
  • Gap junctions
  • Glial fibrillary acidic protein
  • Gliotransmitters
  • Neurovascular coupling
  • Radial glia

ASJC Scopus subject areas

  • Medicine(all)


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