Associations of urinary phthalate and phenol biomarkers with menarche in a multiethnic cohort of young girls

Mary S. Wolff, Ashley Pajak, Susan M. Pinney, Gayle C. Windham, Maida Galvez, Michael Rybak, Manori J. Silva, Xiaoyun Ye, Antonia M. Calafat, Lawrence H. Kushi, Frank M. Biro, Susan L. Teitelbaum

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

To study potential environmental influences on puberty in girls, we investigated urinary biomarkers in relation to age at menarche. Phenols and phthalates were measured at baseline (6–8 years of age). Menarche was ascertained over 11 years for 1051 girls with menarche and biomarkers. Hazards ratios were estimated from Cox models adjusted for race/ethnicity and caregiver education (aHR, 95% confidence intervals [CI] for 5th vs 1st quintile urinary biomarker concentrations). 2,5-Dichlorophenol was associated with earlier menarche (aHR 1.34 [1.06–1.71]); enterolactone was associated with later menarche (aHR 0.82 [0.66–1.03]), as was mono-3-carboxypropyl phthalate (MCPP) (aHR 0.73 [0.59–0.91]); the three p-trends were <0.05. Menarche differed by 4–7 months across this range. Enterolactone and MCPP associations were stronger in girls with below-median body mass index. These analytes were also associated with age at breast development in this cohort. Findings from this prospective study suggest that some childhood exposures are associated with pubertal timing.

Original languageEnglish (US)
Pages (from-to)56-64
Number of pages9
JournalReproductive Toxicology
Volume67
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Fingerprint

Menarche
Biomarkers
Phenol
Phenols
Hazards
Education
Puberty
Proportional Hazards Models
Caregivers
phthalic acid
Breast
Body Mass Index
Prospective Studies
Confidence Intervals
2,3-bis(3'-hydroxybenzyl)butyrolactone

Keywords

  • Environmental
  • Menarche
  • Phenols
  • Phthalates
  • Phytoestrogens

ASJC Scopus subject areas

  • Toxicology

Cite this

Wolff, M. S., Pajak, A., Pinney, S. M., Windham, G. C., Galvez, M., Rybak, M., ... Teitelbaum, S. L. (2017). Associations of urinary phthalate and phenol biomarkers with menarche in a multiethnic cohort of young girls. Reproductive Toxicology, 67, 56-64. https://doi.org/10.1016/j.reprotox.2016.11.009

Associations of urinary phthalate and phenol biomarkers with menarche in a multiethnic cohort of young girls. / Wolff, Mary S.; Pajak, Ashley; Pinney, Susan M.; Windham, Gayle C.; Galvez, Maida; Rybak, Michael; Silva, Manori J.; Ye, Xiaoyun; Calafat, Antonia M.; Kushi, Lawrence H.; Biro, Frank M.; Teitelbaum, Susan L.

In: Reproductive Toxicology, Vol. 67, 01.01.2017, p. 56-64.

Research output: Contribution to journalArticle

Wolff, MS, Pajak, A, Pinney, SM, Windham, GC, Galvez, M, Rybak, M, Silva, MJ, Ye, X, Calafat, AM, Kushi, LH, Biro, FM & Teitelbaum, SL 2017, 'Associations of urinary phthalate and phenol biomarkers with menarche in a multiethnic cohort of young girls', Reproductive Toxicology, vol. 67, pp. 56-64. https://doi.org/10.1016/j.reprotox.2016.11.009
Wolff, Mary S. ; Pajak, Ashley ; Pinney, Susan M. ; Windham, Gayle C. ; Galvez, Maida ; Rybak, Michael ; Silva, Manori J. ; Ye, Xiaoyun ; Calafat, Antonia M. ; Kushi, Lawrence H. ; Biro, Frank M. ; Teitelbaum, Susan L. / Associations of urinary phthalate and phenol biomarkers with menarche in a multiethnic cohort of young girls. In: Reproductive Toxicology. 2017 ; Vol. 67. pp. 56-64.
@article{126bc83352fe44bfbc01be5feb22f13e,
title = "Associations of urinary phthalate and phenol biomarkers with menarche in a multiethnic cohort of young girls",
abstract = "To study potential environmental influences on puberty in girls, we investigated urinary biomarkers in relation to age at menarche. Phenols and phthalates were measured at baseline (6–8 years of age). Menarche was ascertained over 11 years for 1051 girls with menarche and biomarkers. Hazards ratios were estimated from Cox models adjusted for race/ethnicity and caregiver education (aHR, 95{\%} confidence intervals [CI] for 5th vs 1st quintile urinary biomarker concentrations). 2,5-Dichlorophenol was associated with earlier menarche (aHR 1.34 [1.06–1.71]); enterolactone was associated with later menarche (aHR 0.82 [0.66–1.03]), as was mono-3-carboxypropyl phthalate (MCPP) (aHR 0.73 [0.59–0.91]); the three p-trends were <0.05. Menarche differed by 4–7 months across this range. Enterolactone and MCPP associations were stronger in girls with below-median body mass index. These analytes were also associated with age at breast development in this cohort. Findings from this prospective study suggest that some childhood exposures are associated with pubertal timing.",
keywords = "Environmental, Menarche, Phenols, Phthalates, Phytoestrogens",
author = "Wolff, {Mary S.} and Ashley Pajak and Pinney, {Susan M.} and Windham, {Gayle C.} and Maida Galvez and Michael Rybak and Silva, {Manori J.} and Xiaoyun Ye and Calafat, {Antonia M.} and Kushi, {Lawrence H.} and Biro, {Frank M.} and Teitelbaum, {Susan L.}",
year = "2017",
month = "1",
day = "1",
doi = "10.1016/j.reprotox.2016.11.009",
language = "English (US)",
volume = "67",
pages = "56--64",
journal = "Reproductigve Toxicoloy",
issn = "0890-6238",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Associations of urinary phthalate and phenol biomarkers with menarche in a multiethnic cohort of young girls

AU - Wolff, Mary S.

AU - Pajak, Ashley

AU - Pinney, Susan M.

AU - Windham, Gayle C.

AU - Galvez, Maida

AU - Rybak, Michael

AU - Silva, Manori J.

AU - Ye, Xiaoyun

AU - Calafat, Antonia M.

AU - Kushi, Lawrence H.

AU - Biro, Frank M.

AU - Teitelbaum, Susan L.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - To study potential environmental influences on puberty in girls, we investigated urinary biomarkers in relation to age at menarche. Phenols and phthalates were measured at baseline (6–8 years of age). Menarche was ascertained over 11 years for 1051 girls with menarche and biomarkers. Hazards ratios were estimated from Cox models adjusted for race/ethnicity and caregiver education (aHR, 95% confidence intervals [CI] for 5th vs 1st quintile urinary biomarker concentrations). 2,5-Dichlorophenol was associated with earlier menarche (aHR 1.34 [1.06–1.71]); enterolactone was associated with later menarche (aHR 0.82 [0.66–1.03]), as was mono-3-carboxypropyl phthalate (MCPP) (aHR 0.73 [0.59–0.91]); the three p-trends were <0.05. Menarche differed by 4–7 months across this range. Enterolactone and MCPP associations were stronger in girls with below-median body mass index. These analytes were also associated with age at breast development in this cohort. Findings from this prospective study suggest that some childhood exposures are associated with pubertal timing.

AB - To study potential environmental influences on puberty in girls, we investigated urinary biomarkers in relation to age at menarche. Phenols and phthalates were measured at baseline (6–8 years of age). Menarche was ascertained over 11 years for 1051 girls with menarche and biomarkers. Hazards ratios were estimated from Cox models adjusted for race/ethnicity and caregiver education (aHR, 95% confidence intervals [CI] for 5th vs 1st quintile urinary biomarker concentrations). 2,5-Dichlorophenol was associated with earlier menarche (aHR 1.34 [1.06–1.71]); enterolactone was associated with later menarche (aHR 0.82 [0.66–1.03]), as was mono-3-carboxypropyl phthalate (MCPP) (aHR 0.73 [0.59–0.91]); the three p-trends were <0.05. Menarche differed by 4–7 months across this range. Enterolactone and MCPP associations were stronger in girls with below-median body mass index. These analytes were also associated with age at breast development in this cohort. Findings from this prospective study suggest that some childhood exposures are associated with pubertal timing.

KW - Environmental

KW - Menarche

KW - Phenols

KW - Phthalates

KW - Phytoestrogens

UR - http://www.scopus.com/inward/record.url?scp=84998693047&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84998693047&partnerID=8YFLogxK

U2 - 10.1016/j.reprotox.2016.11.009

DO - 10.1016/j.reprotox.2016.11.009

M3 - Article

AN - SCOPUS:84998693047

VL - 67

SP - 56

EP - 64

JO - Reproductigve Toxicoloy

JF - Reproductigve Toxicoloy

SN - 0890-6238

ER -