Associations of serum nonesterified fatty acids with coronary heart disease mortality and nonfatal myocardial infarction: The chs (cardiovascular health study) cohort

Neil K. Huang, Petra Bůžková, Nirupa R. Matthan, Luc Djoussé, Calvin H. Hirsch, Jorge R. Kizer, W. T. Longstreth, Kenneth J. Mukamal, Alice H. Lichtenstein

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Significant associations have been reported between serum total nonesterified fatty acid (NEFA) concentrations and coronary heart disease (CHD) mortality and incident nonfatal myocardial infarction (MI) in some prospective cohort stud-ies. Little is known about whether individual or subclasses (saturated, polyunsaturated [n-6 and n-3], and trans fatty acids) of serum NEFAs relate to CHD mortality and nonfatal MI. METHODS AND RESULTS: CHS (Cardiovascular Health Study) participants (N=1681) who had no history of MI, angina, or re-vascularization or were free of MI at baseline (1996–1997) were included. NEFAs were quantified using gas chromatography. Cox regression analysis was used to evaluate associations of 5 subclasses and individual NEFAs with CHD composite (CHD mortality and nonfatal MI), CHD mortality, and incident nonfatal MI. During a median follow-up of 11.7 years, 266 cases of CHD death and 271 cases of nonfatal MI occurred. In the fully adjusted model, no significant associations were identified between individual NEFA and CHD composite. Exploratory analyses indicated that lauric acid (12:0) was negatively associated (hazard ratio [HR], 0.76; 95% CI, 0.59–0.98; P=0.0328) and dihomo-γ-linolenic acid (20:3n-6) was positively associated with CHD mortality (HR, 1.34; 95% CI, 1.02–1.76; P=0.0351). Elaidic acid (18:1n-7t) was positively associated with incident nonfatal MI (HR, 1.46; 95% CI, 1.01–2.12; P=0.0445). No significant associations were observed for NEFA subclass and any outcomes. CONCLUSIONS: In CHS participants, 2 NEFAs, dihomo-γ-linolenic and elaidic acids, were positively associated with CHD mortality and nonfatal MI, respectively, suggesting potential susceptibility biomarkers for risks of CHD mortality and nonfatal MI.

Original languageEnglish (US)
Article numbere019135
JournalJournal of the American Heart Association
Volume10
Issue number6
DOIs
StatePublished - 2021

Keywords

  • Coronary heart disease mortality
  • Dihomo-γ-linolenic acid
  • Epidemiology
  • Incident nonfatal myocardial infarction
  • Serum nonesterified fatty acid
  • Trans fat

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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