Associations of proinflammatory cytokine levels with lipid profiles, growth, and body composition in HIV-infected children initiating or changing antiretroviral therapy

Joseph S. Cervia, Caroline J Chantry, Michael D. Hughes, Carmelita Alvero, William A. Meyer, Janice Hodge, Peggy Borum, Jack Moye, Stephen A. Spector

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objectives: To measure proinflammatory cytokines (PIC) in HIV-infected children beginning or changing antiretroviral therapy (ART), evaluating associations with virologic, immunologic, serum lipid, growth, and body composition measures, markers of growth hormone action and glucose metabolism. Methods: Forty-nine prepubertal HIV-infected children had measurements of viral load (VL), CD4 lymphocyte count and percentage, serum lipids, apolipoprotein AI/B, IGF-1, IGFBP-1, and IGFBP-3, anthropometry, bioelectrical impedance analysis, TNF-α, IL-1 β, and IL-6 at baseline and 48 weeks of ART. Results: Baseline levels were detectable (>0.1 pg/mL) for IL-1 β in 28 of 48, and for TNF-α and Il-6 in all 49 children. TNF-α decreased with ART (P < 0.001) and IL-6 demonstrated a similar trend (P = 0.065). Children with 48-week VL <400 copies/mL had greater declines in TNF-α (mean 45%) than subjects with higher VL (5%; P = 0.009). Each 10% improvement in CD4% was associated with 26% lower TNF-α (P = 0.002) and 31% lower IL-6 (P = 0.016). Greater reductions in TNF-α were associated with lower total/HDL cholesterol ratio (P = 0.003) at week 48. Conclusions: In HIV-infected children initiating or changing ART, PIC were detectable at baseline and decreased over 48 weeks. Better immunologic responses were associated with greater reductions in TNF-α and IL-6. Reductions in TNF-α were associated with improved total/HDL cholesterol ratio.

Original languageEnglish (US)
Pages (from-to)1118-1122
Number of pages5
JournalPediatric Infectious Disease Journal
Volume29
Issue number12
DOIs
StatePublished - Dec 2010

Fingerprint

Body Composition
HIV
Cytokines
Interleukin-6
Lipids
Viral Load
Growth
Interleukin-1
HDL Cholesterol
Body Weights and Measures
Insulin-Like Growth Factor Binding Protein 1
Therapeutics
Anthropometry
Insulin-Like Growth Factor Binding Protein 3
Apolipoprotein A-I
Apolipoproteins B
CD4 Lymphocyte Count
Serum
Electric Impedance
Insulin-Like Growth Factor I

Keywords

  • antiretroviral therapy
  • children
  • HIV
  • lipid profile
  • proinflammatory cytokines

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases
  • Microbiology (medical)

Cite this

Associations of proinflammatory cytokine levels with lipid profiles, growth, and body composition in HIV-infected children initiating or changing antiretroviral therapy. / Cervia, Joseph S.; Chantry, Caroline J; Hughes, Michael D.; Alvero, Carmelita; Meyer, William A.; Hodge, Janice; Borum, Peggy; Moye, Jack; Spector, Stephen A.

In: Pediatric Infectious Disease Journal, Vol. 29, No. 12, 12.2010, p. 1118-1122.

Research output: Contribution to journalArticle

Cervia, Joseph S. ; Chantry, Caroline J ; Hughes, Michael D. ; Alvero, Carmelita ; Meyer, William A. ; Hodge, Janice ; Borum, Peggy ; Moye, Jack ; Spector, Stephen A. / Associations of proinflammatory cytokine levels with lipid profiles, growth, and body composition in HIV-infected children initiating or changing antiretroviral therapy. In: Pediatric Infectious Disease Journal. 2010 ; Vol. 29, No. 12. pp. 1118-1122.
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abstract = "Objectives: To measure proinflammatory cytokines (PIC) in HIV-infected children beginning or changing antiretroviral therapy (ART), evaluating associations with virologic, immunologic, serum lipid, growth, and body composition measures, markers of growth hormone action and glucose metabolism. Methods: Forty-nine prepubertal HIV-infected children had measurements of viral load (VL), CD4 lymphocyte count and percentage, serum lipids, apolipoprotein AI/B, IGF-1, IGFBP-1, and IGFBP-3, anthropometry, bioelectrical impedance analysis, TNF-α, IL-1 β, and IL-6 at baseline and 48 weeks of ART. Results: Baseline levels were detectable (>0.1 pg/mL) for IL-1 β in 28 of 48, and for TNF-α and Il-6 in all 49 children. TNF-α decreased with ART (P < 0.001) and IL-6 demonstrated a similar trend (P = 0.065). Children with 48-week VL <400 copies/mL had greater declines in TNF-α (mean 45{\%}) than subjects with higher VL (5{\%}; P = 0.009). Each 10{\%} improvement in CD4{\%} was associated with 26{\%} lower TNF-α (P = 0.002) and 31{\%} lower IL-6 (P = 0.016). Greater reductions in TNF-α were associated with lower total/HDL cholesterol ratio (P = 0.003) at week 48. Conclusions: In HIV-infected children initiating or changing ART, PIC were detectable at baseline and decreased over 48 weeks. Better immunologic responses were associated with greater reductions in TNF-α and IL-6. Reductions in TNF-α were associated with improved total/HDL cholesterol ratio.",
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T1 - Associations of proinflammatory cytokine levels with lipid profiles, growth, and body composition in HIV-infected children initiating or changing antiretroviral therapy

AU - Cervia, Joseph S.

AU - Chantry, Caroline J

AU - Hughes, Michael D.

AU - Alvero, Carmelita

AU - Meyer, William A.

AU - Hodge, Janice

AU - Borum, Peggy

AU - Moye, Jack

AU - Spector, Stephen A.

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AB - Objectives: To measure proinflammatory cytokines (PIC) in HIV-infected children beginning or changing antiretroviral therapy (ART), evaluating associations with virologic, immunologic, serum lipid, growth, and body composition measures, markers of growth hormone action and glucose metabolism. Methods: Forty-nine prepubertal HIV-infected children had measurements of viral load (VL), CD4 lymphocyte count and percentage, serum lipids, apolipoprotein AI/B, IGF-1, IGFBP-1, and IGFBP-3, anthropometry, bioelectrical impedance analysis, TNF-α, IL-1 β, and IL-6 at baseline and 48 weeks of ART. Results: Baseline levels were detectable (>0.1 pg/mL) for IL-1 β in 28 of 48, and for TNF-α and Il-6 in all 49 children. TNF-α decreased with ART (P < 0.001) and IL-6 demonstrated a similar trend (P = 0.065). Children with 48-week VL <400 copies/mL had greater declines in TNF-α (mean 45%) than subjects with higher VL (5%; P = 0.009). Each 10% improvement in CD4% was associated with 26% lower TNF-α (P = 0.002) and 31% lower IL-6 (P = 0.016). Greater reductions in TNF-α were associated with lower total/HDL cholesterol ratio (P = 0.003) at week 48. Conclusions: In HIV-infected children initiating or changing ART, PIC were detectable at baseline and decreased over 48 weeks. Better immunologic responses were associated with greater reductions in TNF-α and IL-6. Reductions in TNF-α were associated with improved total/HDL cholesterol ratio.

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