Abstract
A nested case-cohort study was performed in participants of a clinical trial of first-line human immunodeficiency virus treatments to investigate plasma biomarkers of inflammation and microbial translocation for their association with immune reconstitution inflammatory syndrome (IRIS). Fifty-one of 1452 participants with baseline CD4 count <350 cells/μL developed IRIS. Plasma from 51 IRIS cases, including 6 stratified by preenrollment CD4 count ≤200 cells/μL, were analyzed and compared to 94 non-IRIS controls. At baseline, CXCL10, lipopolysaccharide, soluble CD14, 16S ribosomal DNA, and interferon-α2 were associated with greater risk of IRIS. Systemic inflammation through persistent monocyte activation and microbial translocation appear to be important in IRIS pathogenesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1159-1163 |
| Number of pages | 5 |
| Journal | The Journal of infectious diseases |
| Volume | 216 |
| Issue number | 9 |
| DOIs | |
| State | Published - Nov 27 2017 |
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Keywords
- cytokines
- immune reconstitution inflammatory syndrome
- IRIS
- microbial translocation
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases
Cite this
Associations of Plasma Cytokine and Microbial Translocation Biomarkers With Immune Reconstitution Inflammatory Syndrome. / AIDS Clinical Trials Group A5202 Study Team.
In: The Journal of infectious diseases, Vol. 216, No. 9, 27.11.2017, p. 1159-1163.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Associations of Plasma Cytokine and Microbial Translocation Biomarkers With Immune Reconstitution Inflammatory Syndrome
AU - AIDS Clinical Trials Group A5202 Study Team
AU - George, Varghese
AU - Harrison, Linda
AU - Roach, Margaret
AU - Li, Xiao Dong
AU - Tierney, Camlin
AU - Fischl, Margaret A.
AU - Aberg, Judith
AU - Tebas, Pablo
AU - Asmuth, David
AU - Pollard, Richard B
AU - Godfrey, Catherine
AU - Pahwa, Savita
PY - 2017/11/27
Y1 - 2017/11/27
N2 - A nested case-cohort study was performed in participants of a clinical trial of first-line human immunodeficiency virus treatments to investigate plasma biomarkers of inflammation and microbial translocation for their association with immune reconstitution inflammatory syndrome (IRIS). Fifty-one of 1452 participants with baseline CD4 count <350 cells/μL developed IRIS. Plasma from 51 IRIS cases, including 6 stratified by preenrollment CD4 count ≤200 cells/μL, were analyzed and compared to 94 non-IRIS controls. At baseline, CXCL10, lipopolysaccharide, soluble CD14, 16S ribosomal DNA, and interferon-α2 were associated with greater risk of IRIS. Systemic inflammation through persistent monocyte activation and microbial translocation appear to be important in IRIS pathogenesis.
AB - A nested case-cohort study was performed in participants of a clinical trial of first-line human immunodeficiency virus treatments to investigate plasma biomarkers of inflammation and microbial translocation for their association with immune reconstitution inflammatory syndrome (IRIS). Fifty-one of 1452 participants with baseline CD4 count <350 cells/μL developed IRIS. Plasma from 51 IRIS cases, including 6 stratified by preenrollment CD4 count ≤200 cells/μL, were analyzed and compared to 94 non-IRIS controls. At baseline, CXCL10, lipopolysaccharide, soluble CD14, 16S ribosomal DNA, and interferon-α2 were associated with greater risk of IRIS. Systemic inflammation through persistent monocyte activation and microbial translocation appear to be important in IRIS pathogenesis.
KW - cytokines
KW - immune reconstitution inflammatory syndrome
KW - IRIS
KW - microbial translocation
UR - http://www.scopus.com/inward/record.url?scp=85038235079&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85038235079&partnerID=8YFLogxK
U2 - 10.1093/infdis/jix460
DO - 10.1093/infdis/jix460
M3 - Article
C2 - 29040604
AN - SCOPUS:85038235079
VL - 216
SP - 1159
EP - 1163
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 9
ER -