Abstract
A nested case-cohort study was performed in participants of a clinical trial of first-line human immunodeficiency virus treatments to investigate plasma biomarkers of inflammation and microbial translocation for their association with immune reconstitution inflammatory syndrome (IRIS). Fifty-one of 1452 participants with baseline CD4 count <350 cells/μL developed IRIS. Plasma from 51 IRIS cases, including 6 stratified by preenrollment CD4 count ≤200 cells/μL, were analyzed and compared to 94 non-IRIS controls. At baseline, CXCL10, lipopolysaccharide, soluble CD14, 16S ribosomal DNA, and interferon-α2 were associated with greater risk of IRIS. Systemic inflammation through persistent monocyte activation and microbial translocation appear to be important in IRIS pathogenesis.
Original language | English (US) |
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Pages (from-to) | 1159-1163 |
Number of pages | 5 |
Journal | The Journal of infectious diseases |
Volume | 216 |
Issue number | 9 |
DOIs | |
State | Published - Nov 27 2017 |
Keywords
- cytokines
- immune reconstitution inflammatory syndrome
- IRIS
- microbial translocation
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases