Associations of Plasma Cytokine and Microbial Translocation Biomarkers With Immune Reconstitution Inflammatory Syndrome

AIDS Clinical Trials Group A5202 Study Team

doi:10.1093/infdis/jix460

Associations of Plasma Cytokine and Microbial Translocation Biomarkers With Immune Reconstitution Inflammatory Syndrome

AIDS Clinical Trials Group A5202 Study Team

Infectious Diseases

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A nested case-cohort study was performed in participants of a clinical trial of first-line human immunodeficiency virus treatments to investigate plasma biomarkers of inflammation and microbial translocation for their association with immune reconstitution inflammatory syndrome (IRIS). Fifty-one of 1452 participants with baseline CD4 count <350 cells/μL developed IRIS. Plasma from 51 IRIS cases, including 6 stratified by preenrollment CD4 count ≤200 cells/μL, were analyzed and compared to 94 non-IRIS controls. At baseline, CXCL10, lipopolysaccharide, soluble CD14, 16S ribosomal DNA, and interferon-α2 were associated with greater risk of IRIS. Systemic inflammation through persistent monocyte activation and microbial translocation appear to be important in IRIS pathogenesis.

Original language	English (US)
Pages (from-to)	1159-1163
Number of pages	5
Journal	The Journal of infectious diseases
Volume	216
Issue number	9
DOIs	https://doi.org/10.1093/infdis/jix460
State	Published - Nov 27 2017

Keywords

cytokines
immune reconstitution inflammatory syndrome
IRIS
microbial translocation

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

Access to Document

10.1093/infdis/jix460

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title = "Associations of Plasma Cytokine and Microbial Translocation Biomarkers With Immune Reconstitution Inflammatory Syndrome",

abstract = "A nested case-cohort study was performed in participants of a clinical trial of first-line human immunodeficiency virus treatments to investigate plasma biomarkers of inflammation and microbial translocation for their association with immune reconstitution inflammatory syndrome (IRIS). Fifty-one of 1452 participants with baseline CD4 count <350 cells/μL developed IRIS. Plasma from 51 IRIS cases, including 6 stratified by preenrollment CD4 count ≤200 cells/μL, were analyzed and compared to 94 non-IRIS controls. At baseline, CXCL10, lipopolysaccharide, soluble CD14, 16S ribosomal DNA, and interferon-α2 were associated with greater risk of IRIS. Systemic inflammation through persistent monocyte activation and microbial translocation appear to be important in IRIS pathogenesis.",

keywords = "cytokines, immune reconstitution inflammatory syndrome, IRIS, microbial translocation",

author = "{AIDS Clinical Trials Group A5202 Study Team} and Varghese George and Linda Harrison and Margaret Roach and Li, {Xiao Dong} and Camlin Tierney and Fischl, {Margaret A.} and Judith Aberg and Pablo Tebas and David Asmuth and Pollard, {Richard B} and Catherine Godfrey and Savita Pahwa",

year = "2017",

month = nov,

day = "27",

doi = "10.1093/infdis/jix460",

language = "English (US)",

volume = "216",

pages = "1159--1163",

journal = "Journal of Infectious Diseases",

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number = "9",

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TY - JOUR

T1 - Associations of Plasma Cytokine and Microbial Translocation Biomarkers With Immune Reconstitution Inflammatory Syndrome

AU - AIDS Clinical Trials Group A5202 Study Team

AU - George, Varghese

AU - Harrison, Linda

AU - Roach, Margaret

AU - Li, Xiao Dong

AU - Tierney, Camlin

AU - Fischl, Margaret A.

AU - Aberg, Judith

AU - Tebas, Pablo

AU - Asmuth, David

AU - Pollard, Richard B

AU - Godfrey, Catherine

AU - Pahwa, Savita

PY - 2017/11/27

Y1 - 2017/11/27

N2 - A nested case-cohort study was performed in participants of a clinical trial of first-line human immunodeficiency virus treatments to investigate plasma biomarkers of inflammation and microbial translocation for their association with immune reconstitution inflammatory syndrome (IRIS). Fifty-one of 1452 participants with baseline CD4 count <350 cells/μL developed IRIS. Plasma from 51 IRIS cases, including 6 stratified by preenrollment CD4 count ≤200 cells/μL, were analyzed and compared to 94 non-IRIS controls. At baseline, CXCL10, lipopolysaccharide, soluble CD14, 16S ribosomal DNA, and interferon-α2 were associated with greater risk of IRIS. Systemic inflammation through persistent monocyte activation and microbial translocation appear to be important in IRIS pathogenesis.

AB - A nested case-cohort study was performed in participants of a clinical trial of first-line human immunodeficiency virus treatments to investigate plasma biomarkers of inflammation and microbial translocation for their association with immune reconstitution inflammatory syndrome (IRIS). Fifty-one of 1452 participants with baseline CD4 count <350 cells/μL developed IRIS. Plasma from 51 IRIS cases, including 6 stratified by preenrollment CD4 count ≤200 cells/μL, were analyzed and compared to 94 non-IRIS controls. At baseline, CXCL10, lipopolysaccharide, soluble CD14, 16S ribosomal DNA, and interferon-α2 were associated with greater risk of IRIS. Systemic inflammation through persistent monocyte activation and microbial translocation appear to be important in IRIS pathogenesis.

KW - cytokines

KW - immune reconstitution inflammatory syndrome

KW - IRIS

KW - microbial translocation

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