Associations of ghrelin with eating behaviors, stress, metabolic factors, and telomere length among overweight and obese women

Preliminary evidence of attenuated ghrelin effects in obesity?

Julia Buss, Peter J Havel, Elissa Epel, Jue Lin, Elizabeth Blackburn, Jennifer Daubenmier

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Ghrelin regulates homeostatic food intake, hedonic eating, and is a mediator in the stress response. In addition, ghrelin has metabolic, cardiovascular, and anti-aging effects. This cross-sectional study examined associations between total plasma ghrelin, caloric intake based on 3. day diet diaries, hedonic eating attitudes, stress-related and metabolic factors, and leukocyte telomere length in overweight (n= 25) and obese women (n= 22). We hypothesized associations between total plasma ghrelin and eating behaviors, stress, metabolic, cardiovascular, and cell aging factors among overweight women, but not among obese women due to lower circulating ghrelin levels and/or central resistance to ghrelin. Confirming previous studies demonstrating lowered plasma ghrelin in obesity, ghrelin levels were lower in the obese compared with overweight women. Among the overweight, ghrelin was positively correlated with caloric intake, giving in to cravings for highly palatable foods, and a flatter diurnal cortisol slope across 3. days. These relationships were non-significant among the obese group. Among overweight women, ghrelin was negatively correlated with insulin resistance, systolic blood pressure, and heart rate, and positively correlated with telomere length. Among the obese subjects, plasma ghrelin concentrations were negatively correlated with insulin resistance, but were not significantly correlated with blood pressure, heart rate or telomere length. Total plasma ghrelin and its associations with food intake, hedonic eating, and stress are decreased in obesity, providing evidence consistent with the theory that central resistance to ghrelin develops in obesity and ghrelin's function in appetite regulation may have evolved to prevent starvation in food scarcity rather than cope with modern food excess. Furthermore, ghrelin is associated with metabolic and cardiovascular health, and may have anti-aging effects, but these effects may be attenuated in obesity.

Original languageEnglish (US)
Pages (from-to)84-94
Number of pages11
JournalAppetite
Volume76
DOIs
StatePublished - May 1 2014

Fingerprint

Ghrelin
Telomere
Feeding Behavior
Obesity
Eating
Pleasure
Blood Pressure
Energy Intake
Food
Insulin Resistance
Heart Rate
Appetite Regulation
Cell Aging
Starvation

Keywords

  • Hedonic eating
  • Leukocyte telomere length
  • Metabolic factors
  • Stress
  • Total plasma ghrelin

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Psychology(all)
  • Medicine(all)

Cite this

Associations of ghrelin with eating behaviors, stress, metabolic factors, and telomere length among overweight and obese women : Preliminary evidence of attenuated ghrelin effects in obesity? / Buss, Julia; Havel, Peter J; Epel, Elissa; Lin, Jue; Blackburn, Elizabeth; Daubenmier, Jennifer.

In: Appetite, Vol. 76, 01.05.2014, p. 84-94.

Research output: Contribution to journalArticle

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