Associations of dietary protein with disease and mortality in a prospective study of postmenopausal women

Linda E. Kelemen, Lawrence H. Kushi, David R. Jacobs, James R. Cerhan

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Some weight loss diets promote protein intake; however, the association of protein with disease is unclear. In 1986, 29,017 postmenopausal Iowa women without cancer, coronary heart disease (CHD), or diabetes were followed prospectively for 15 years for cancer incidence and mortality from CHD, cancer, and all causes. Mailed questionnaires assessed dietary, lifestyle, and medical information. Nutrient density models estimated risk ratios from a simulated substitution of total and type of dietary protein for carbohydrate and of vegetable for animal protein. The authors identified 4,843 new cancers, 739 CHD deaths, 1,676 cancer deaths, and 3,978 total deaths. Among women in the highest intake quintile, CHD mortality decreased by 30% from an isoenergetic substitution of vegetable protein for carbohydrate (95% confidence interval (CI): 0.49, 0.99) and of vegetable for animal protein (95% CI: 0.51, 0.98), following multivariable adjustment. Although no association was observed with any outcome when animal protein was substituted for carbohydrate, CHD mortality was associated with red meats (risk ratio = 1.44, 95% CI: 1.06, 1.94) and dairy products (risk ratio = 1.41, 95% CI: 1.07, 1.86) when substituted for servings per 1,000 kcal (4.2 MJ) of carbohydrate foods. Long-term adherence to high-protein diets, without discrimination toward protein source, may have potentially adverse health consequences.

Original languageEnglish (US)
Pages (from-to)239-249
Number of pages11
JournalAmerican Journal of Epidemiology
Volume161
Issue number3
DOIs
StatePublished - Feb 1 2005
Externally publishedYes

Fingerprint

Dietary Proteins
Coronary Disease
Vegetable Proteins
Prospective Studies
Mortality
Confidence Intervals
Odds Ratio
Carbohydrates
Proteins
Neoplasms
Reducing Diet
Dietary Carbohydrates
Social Adjustment
Food
Heart Neoplasms
Dairy Products
Life Style
Diet
Incidence
Health

Keywords

  • Dietary carbohydrates
  • Dietary proteins
  • Heart diseases
  • Mortality
  • Neoplasms
  • Postmenopause
  • Prospective studies

ASJC Scopus subject areas

  • Epidemiology

Cite this

Associations of dietary protein with disease and mortality in a prospective study of postmenopausal women. / Kelemen, Linda E.; Kushi, Lawrence H.; Jacobs, David R.; Cerhan, James R.

In: American Journal of Epidemiology, Vol. 161, No. 3, 01.02.2005, p. 239-249.

Research output: Contribution to journalArticle

Kelemen, Linda E. ; Kushi, Lawrence H. ; Jacobs, David R. ; Cerhan, James R. / Associations of dietary protein with disease and mortality in a prospective study of postmenopausal women. In: American Journal of Epidemiology. 2005 ; Vol. 161, No. 3. pp. 239-249.
@article{819f5e5612d644f4b18113ca026f811d,
title = "Associations of dietary protein with disease and mortality in a prospective study of postmenopausal women",
abstract = "Some weight loss diets promote protein intake; however, the association of protein with disease is unclear. In 1986, 29,017 postmenopausal Iowa women without cancer, coronary heart disease (CHD), or diabetes were followed prospectively for 15 years for cancer incidence and mortality from CHD, cancer, and all causes. Mailed questionnaires assessed dietary, lifestyle, and medical information. Nutrient density models estimated risk ratios from a simulated substitution of total and type of dietary protein for carbohydrate and of vegetable for animal protein. The authors identified 4,843 new cancers, 739 CHD deaths, 1,676 cancer deaths, and 3,978 total deaths. Among women in the highest intake quintile, CHD mortality decreased by 30{\%} from an isoenergetic substitution of vegetable protein for carbohydrate (95{\%} confidence interval (CI): 0.49, 0.99) and of vegetable for animal protein (95{\%} CI: 0.51, 0.98), following multivariable adjustment. Although no association was observed with any outcome when animal protein was substituted for carbohydrate, CHD mortality was associated with red meats (risk ratio = 1.44, 95{\%} CI: 1.06, 1.94) and dairy products (risk ratio = 1.41, 95{\%} CI: 1.07, 1.86) when substituted for servings per 1,000 kcal (4.2 MJ) of carbohydrate foods. Long-term adherence to high-protein diets, without discrimination toward protein source, may have potentially adverse health consequences.",
keywords = "Dietary carbohydrates, Dietary proteins, Heart diseases, Mortality, Neoplasms, Postmenopause, Prospective studies",
author = "Kelemen, {Linda E.} and Kushi, {Lawrence H.} and Jacobs, {David R.} and Cerhan, {James R.}",
year = "2005",
month = "2",
day = "1",
doi = "10.1093/aje/kwi038",
language = "English (US)",
volume = "161",
pages = "239--249",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "3",

}

TY - JOUR

T1 - Associations of dietary protein with disease and mortality in a prospective study of postmenopausal women

AU - Kelemen, Linda E.

AU - Kushi, Lawrence H.

AU - Jacobs, David R.

AU - Cerhan, James R.

PY - 2005/2/1

Y1 - 2005/2/1

N2 - Some weight loss diets promote protein intake; however, the association of protein with disease is unclear. In 1986, 29,017 postmenopausal Iowa women without cancer, coronary heart disease (CHD), or diabetes were followed prospectively for 15 years for cancer incidence and mortality from CHD, cancer, and all causes. Mailed questionnaires assessed dietary, lifestyle, and medical information. Nutrient density models estimated risk ratios from a simulated substitution of total and type of dietary protein for carbohydrate and of vegetable for animal protein. The authors identified 4,843 new cancers, 739 CHD deaths, 1,676 cancer deaths, and 3,978 total deaths. Among women in the highest intake quintile, CHD mortality decreased by 30% from an isoenergetic substitution of vegetable protein for carbohydrate (95% confidence interval (CI): 0.49, 0.99) and of vegetable for animal protein (95% CI: 0.51, 0.98), following multivariable adjustment. Although no association was observed with any outcome when animal protein was substituted for carbohydrate, CHD mortality was associated with red meats (risk ratio = 1.44, 95% CI: 1.06, 1.94) and dairy products (risk ratio = 1.41, 95% CI: 1.07, 1.86) when substituted for servings per 1,000 kcal (4.2 MJ) of carbohydrate foods. Long-term adherence to high-protein diets, without discrimination toward protein source, may have potentially adverse health consequences.

AB - Some weight loss diets promote protein intake; however, the association of protein with disease is unclear. In 1986, 29,017 postmenopausal Iowa women without cancer, coronary heart disease (CHD), or diabetes were followed prospectively for 15 years for cancer incidence and mortality from CHD, cancer, and all causes. Mailed questionnaires assessed dietary, lifestyle, and medical information. Nutrient density models estimated risk ratios from a simulated substitution of total and type of dietary protein for carbohydrate and of vegetable for animal protein. The authors identified 4,843 new cancers, 739 CHD deaths, 1,676 cancer deaths, and 3,978 total deaths. Among women in the highest intake quintile, CHD mortality decreased by 30% from an isoenergetic substitution of vegetable protein for carbohydrate (95% confidence interval (CI): 0.49, 0.99) and of vegetable for animal protein (95% CI: 0.51, 0.98), following multivariable adjustment. Although no association was observed with any outcome when animal protein was substituted for carbohydrate, CHD mortality was associated with red meats (risk ratio = 1.44, 95% CI: 1.06, 1.94) and dairy products (risk ratio = 1.41, 95% CI: 1.07, 1.86) when substituted for servings per 1,000 kcal (4.2 MJ) of carbohydrate foods. Long-term adherence to high-protein diets, without discrimination toward protein source, may have potentially adverse health consequences.

KW - Dietary carbohydrates

KW - Dietary proteins

KW - Heart diseases

KW - Mortality

KW - Neoplasms

KW - Postmenopause

KW - Prospective studies

UR - http://www.scopus.com/inward/record.url?scp=13544270846&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13544270846&partnerID=8YFLogxK

U2 - 10.1093/aje/kwi038

DO - 10.1093/aje/kwi038

M3 - Article

C2 - 15671256

AN - SCOPUS:13544270846

VL - 161

SP - 239

EP - 249

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 3

ER -