TY - JOUR
T1 - Associations between peripheral inflammation and resting state functional connectivity in adolescents
AU - Swartz, Johnna R.
AU - Carranza, Angelica F.
AU - Tully, Laura M.
AU - Knodt, Annchen R.
AU - Jiang, Janina
AU - Irwin, Michael R.
AU - Hostinar, Camelia E.
N1 - Funding Information:
This work was supported by UC Davis, Prop. 63, the Mental Health Services Act and the Behavioral Health Center of Excellence at UC Davis (JRS) and the USDA National Institute of Food and Agriculture, Hatch project 1013485 (JRS). AFC was supported by the Eugene Cota Robles Fellowship from UC Davis. Part of this research was conducted at the UC Davis Clinical and Translational Science Center Clinical Research Center, which is supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through grant number UL1 TR001860. LMT was supported by a Building Interdisciplinary Research Careers in Women's Health award (K12 HD051958, PI: Ellen B. Gold, PhD), funded by the National Institute of Child Health and Human Development (NICHD), Office of Research on Women's Health, Office of Dietary Supplements, and the National Institute of Aging. The authors would like to thank the participants of the study for their time.
Funding Information:
This work was supported by UC Davis, Prop. 63, the Mental Health Services Act and the Behavioral Health Center of Excellence at UC Davis (JRS) and the USDA National Institute of Food and Agriculture, Hatch project 1013485 (JRS). AFC was supported by the Eugene Cota Robles Fellowship from UC Davis. Part of this research was conducted at the UC Davis Clinical and Translational Science Center Clinical Research Center, which is supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through grant number UL1 TR001860. LMT was supported by a Building Interdisciplinary Research Careers in Women’s Health award (K12 HD051958, PI: Ellen B. Gold, PhD), funded by the National Institute of Child Health and Human Development (NICHD), Office of Research on Women’s Health, Office of Dietary Supplements, and the National Institute of Aging. The authors would like to thank the participants of the study for their time.
Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021
Y1 - 2021
N2 - Relatively little is known about associations between peripheral inflammation and neural function in humans. Neuroimaging studies in adults have suggested that elevated peripheral inflammatory markers are associated with altered resting state functional connectivity (rsFC) in several brain networks associated with mood and cognition. Few studies have examined these associations in adolescents, yet scarce data from adolescents point to different networks than adult studies. The current study examined the associations between peripheral inflammation and rsFC in a community sample of adolescents (n = 70; age, 12–15 years; 32 female, 36 male, 2 nonbinary). After blood sampling, an fMRI scan was performed to assess rsFC. Assay for serum inflammatory markers, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP), was performed. Results indicated that higher TNF-α was associated with altered rsFC between the right amygdala and left striatum and between the right inferior frontal gyrus and left parietal cortex (p < 0.05 whole-brain corrected). Associations with IL-6 and CRP were not significant. In contrast with findings in adults, inflammation may have unique links with the connectivity of the developing adolescent brain. Results have implications for understanding how peripheral inflammation may influence connectivity during adolescence, when neural networks are undergoing major developmental changes.
AB - Relatively little is known about associations between peripheral inflammation and neural function in humans. Neuroimaging studies in adults have suggested that elevated peripheral inflammatory markers are associated with altered resting state functional connectivity (rsFC) in several brain networks associated with mood and cognition. Few studies have examined these associations in adolescents, yet scarce data from adolescents point to different networks than adult studies. The current study examined the associations between peripheral inflammation and rsFC in a community sample of adolescents (n = 70; age, 12–15 years; 32 female, 36 male, 2 nonbinary). After blood sampling, an fMRI scan was performed to assess rsFC. Assay for serum inflammatory markers, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP), was performed. Results indicated that higher TNF-α was associated with altered rsFC between the right amygdala and left striatum and between the right inferior frontal gyrus and left parietal cortex (p < 0.05 whole-brain corrected). Associations with IL-6 and CRP were not significant. In contrast with findings in adults, inflammation may have unique links with the connectivity of the developing adolescent brain. Results have implications for understanding how peripheral inflammation may influence connectivity during adolescence, when neural networks are undergoing major developmental changes.
KW - Adolescence
KW - Amygdala
KW - Brain
KW - fMRI
KW - Inflammation
KW - Resting state connectivity
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U2 - 10.1016/j.bbi.2021.02.018
DO - 10.1016/j.bbi.2021.02.018
M3 - Article
C2 - 33631285
AN - SCOPUS:85104311330
JO - Brain, Behavior, and Immunity
JF - Brain, Behavior, and Immunity
SN - 0889-1591
ER -