Associations between DSM-IV mental disorders and subsequent heart disease onset: Beyond depression

Kate M. Scott, Peter De Jonge, Jordi Alonso, Maria Carmen Viana, Zhaorui Liu, Siobhan O'Neill, Sergio Aguilar-Gaxiola, Ronny Bruffaerts, Jose Miguel Caldas-De-Almeida, Dan J. Stein, Giovanni De Girolamo, Silvia E. Florescu, Chiyi Hu, Nezar Ismet Taib, Jean Pierre Lépine, Daphna Levinson, Herbert Matschinger, Maria Elena Medina-Mora, Marina Piazza, José A. Posada-VillaHidenori Uda, Bogdan J. Wojtyniak, Carmen C W Lim, Ronald C. Kessler

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background Prior studies on the depression-heart disease association have not usually used diagnostic measures of depression, or taken other mental disorders into consideration. As a result, it is not clear whether the association between depression and heart disease onset reflects a specific association, or the comorbidity between depression and other mental disorders. Additionally, the relative magnitude of associations of a range of mental disorders with heart disease onset is unknown. Methods Face-to-face household surveys were conducted in 19 countries (n = 52,095; person years = 2,141,194). The Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of 16 DSM-IV mental disorders. Heart disease was indicated by self-report of physician's diagnosis, or self-report of heart attack, together with their timing (year). Survival analyses estimated associations between first onset of mental disorders and subsequent heart disease onset. Results After comorbidity adjustment, depression, panic disorder, specific phobia, post-traumatic stress disorder and alcohol use disorders were associated with heart disease onset (ORs 1.3-1.6). Increasing number of mental disorders was associated with heart disease in a dose-response fashion. Mood disorders and alcohol abuse were more strongly associated with earlier onset than later onset heart disease. Associations did not vary by gender. Conclusions Depression, anxiety and alcohol use disorders were significantly associated with heart disease onset; depression was the weakest predictor. If confirmed in future prospective studies, the breadth of psychopathology's links with heart disease onset has substantial clinical and public health implications.

Original languageEnglish (US)
Pages (from-to)5293-5299
Number of pages7
JournalInternational Journal of Cardiology
Volume168
Issue number6
DOIs
StatePublished - Oct 15 2013

Fingerprint

Mental Disorders
Diagnostic and Statistical Manual of Mental Disorders
Heart Diseases
Depression
Self Report
Comorbidity
Alcohols
Social Adjustment
Panic Disorder
Survival Analysis
Post-Traumatic Stress Disorders
Psychopathology
Mood Disorders
Age of Onset
Alcoholism
Anxiety
Public Health
Myocardial Infarction
Prospective Studies
Interviews

Keywords

  • Alcohol abuse
  • Anxiety disorders
  • Comorbidity
  • Depression
  • Heart disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Scott, K. M., De Jonge, P., Alonso, J., Viana, M. C., Liu, Z., O'Neill, S., ... Kessler, R. C. (2013). Associations between DSM-IV mental disorders and subsequent heart disease onset: Beyond depression. International Journal of Cardiology, 168(6), 5293-5299. https://doi.org/10.1016/j.ijcard.2013.08.012

Associations between DSM-IV mental disorders and subsequent heart disease onset : Beyond depression. / Scott, Kate M.; De Jonge, Peter; Alonso, Jordi; Viana, Maria Carmen; Liu, Zhaorui; O'Neill, Siobhan; Aguilar-Gaxiola, Sergio; Bruffaerts, Ronny; Caldas-De-Almeida, Jose Miguel; Stein, Dan J.; De Girolamo, Giovanni; Florescu, Silvia E.; Hu, Chiyi; Taib, Nezar Ismet; Lépine, Jean Pierre; Levinson, Daphna; Matschinger, Herbert; Medina-Mora, Maria Elena; Piazza, Marina; Posada-Villa, José A.; Uda, Hidenori; Wojtyniak, Bogdan J.; Lim, Carmen C W; Kessler, Ronald C.

In: International Journal of Cardiology, Vol. 168, No. 6, 15.10.2013, p. 5293-5299.

Research output: Contribution to journalArticle

Scott, KM, De Jonge, P, Alonso, J, Viana, MC, Liu, Z, O'Neill, S, Aguilar-Gaxiola, S, Bruffaerts, R, Caldas-De-Almeida, JM, Stein, DJ, De Girolamo, G, Florescu, SE, Hu, C, Taib, NI, Lépine, JP, Levinson, D, Matschinger, H, Medina-Mora, ME, Piazza, M, Posada-Villa, JA, Uda, H, Wojtyniak, BJ, Lim, CCW & Kessler, RC 2013, 'Associations between DSM-IV mental disorders and subsequent heart disease onset: Beyond depression', International Journal of Cardiology, vol. 168, no. 6, pp. 5293-5299. https://doi.org/10.1016/j.ijcard.2013.08.012
Scott, Kate M. ; De Jonge, Peter ; Alonso, Jordi ; Viana, Maria Carmen ; Liu, Zhaorui ; O'Neill, Siobhan ; Aguilar-Gaxiola, Sergio ; Bruffaerts, Ronny ; Caldas-De-Almeida, Jose Miguel ; Stein, Dan J. ; De Girolamo, Giovanni ; Florescu, Silvia E. ; Hu, Chiyi ; Taib, Nezar Ismet ; Lépine, Jean Pierre ; Levinson, Daphna ; Matschinger, Herbert ; Medina-Mora, Maria Elena ; Piazza, Marina ; Posada-Villa, José A. ; Uda, Hidenori ; Wojtyniak, Bogdan J. ; Lim, Carmen C W ; Kessler, Ronald C. / Associations between DSM-IV mental disorders and subsequent heart disease onset : Beyond depression. In: International Journal of Cardiology. 2013 ; Vol. 168, No. 6. pp. 5293-5299.
@article{6d1f71ab44374be68fc5df149a799684,
title = "Associations between DSM-IV mental disorders and subsequent heart disease onset: Beyond depression",
abstract = "Background Prior studies on the depression-heart disease association have not usually used diagnostic measures of depression, or taken other mental disorders into consideration. As a result, it is not clear whether the association between depression and heart disease onset reflects a specific association, or the comorbidity between depression and other mental disorders. Additionally, the relative magnitude of associations of a range of mental disorders with heart disease onset is unknown. Methods Face-to-face household surveys were conducted in 19 countries (n = 52,095; person years = 2,141,194). The Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of 16 DSM-IV mental disorders. Heart disease was indicated by self-report of physician's diagnosis, or self-report of heart attack, together with their timing (year). Survival analyses estimated associations between first onset of mental disorders and subsequent heart disease onset. Results After comorbidity adjustment, depression, panic disorder, specific phobia, post-traumatic stress disorder and alcohol use disorders were associated with heart disease onset (ORs 1.3-1.6). Increasing number of mental disorders was associated with heart disease in a dose-response fashion. Mood disorders and alcohol abuse were more strongly associated with earlier onset than later onset heart disease. Associations did not vary by gender. Conclusions Depression, anxiety and alcohol use disorders were significantly associated with heart disease onset; depression was the weakest predictor. If confirmed in future prospective studies, the breadth of psychopathology's links with heart disease onset has substantial clinical and public health implications.",
keywords = "Alcohol abuse, Anxiety disorders, Comorbidity, Depression, Heart disease",
author = "Scott, {Kate M.} and {De Jonge}, Peter and Jordi Alonso and Viana, {Maria Carmen} and Zhaorui Liu and Siobhan O'Neill and Sergio Aguilar-Gaxiola and Ronny Bruffaerts and Caldas-De-Almeida, {Jose Miguel} and Stein, {Dan J.} and {De Girolamo}, Giovanni and Florescu, {Silvia E.} and Chiyi Hu and Taib, {Nezar Ismet} and L{\'e}pine, {Jean Pierre} and Daphna Levinson and Herbert Matschinger and Medina-Mora, {Maria Elena} and Marina Piazza and Posada-Villa, {Jos{\'e} A.} and Hidenori Uda and Wojtyniak, {Bogdan J.} and Lim, {Carmen C W} and Kessler, {Ronald C.}",
year = "2013",
month = "10",
day = "15",
doi = "10.1016/j.ijcard.2013.08.012",
language = "English (US)",
volume = "168",
pages = "5293--5299",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",
number = "6",

}

TY - JOUR

T1 - Associations between DSM-IV mental disorders and subsequent heart disease onset

T2 - Beyond depression

AU - Scott, Kate M.

AU - De Jonge, Peter

AU - Alonso, Jordi

AU - Viana, Maria Carmen

AU - Liu, Zhaorui

AU - O'Neill, Siobhan

AU - Aguilar-Gaxiola, Sergio

AU - Bruffaerts, Ronny

AU - Caldas-De-Almeida, Jose Miguel

AU - Stein, Dan J.

AU - De Girolamo, Giovanni

AU - Florescu, Silvia E.

AU - Hu, Chiyi

AU - Taib, Nezar Ismet

AU - Lépine, Jean Pierre

AU - Levinson, Daphna

AU - Matschinger, Herbert

AU - Medina-Mora, Maria Elena

AU - Piazza, Marina

AU - Posada-Villa, José A.

AU - Uda, Hidenori

AU - Wojtyniak, Bogdan J.

AU - Lim, Carmen C W

AU - Kessler, Ronald C.

PY - 2013/10/15

Y1 - 2013/10/15

N2 - Background Prior studies on the depression-heart disease association have not usually used diagnostic measures of depression, or taken other mental disorders into consideration. As a result, it is not clear whether the association between depression and heart disease onset reflects a specific association, or the comorbidity between depression and other mental disorders. Additionally, the relative magnitude of associations of a range of mental disorders with heart disease onset is unknown. Methods Face-to-face household surveys were conducted in 19 countries (n = 52,095; person years = 2,141,194). The Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of 16 DSM-IV mental disorders. Heart disease was indicated by self-report of physician's diagnosis, or self-report of heart attack, together with their timing (year). Survival analyses estimated associations between first onset of mental disorders and subsequent heart disease onset. Results After comorbidity adjustment, depression, panic disorder, specific phobia, post-traumatic stress disorder and alcohol use disorders were associated with heart disease onset (ORs 1.3-1.6). Increasing number of mental disorders was associated with heart disease in a dose-response fashion. Mood disorders and alcohol abuse were more strongly associated with earlier onset than later onset heart disease. Associations did not vary by gender. Conclusions Depression, anxiety and alcohol use disorders were significantly associated with heart disease onset; depression was the weakest predictor. If confirmed in future prospective studies, the breadth of psychopathology's links with heart disease onset has substantial clinical and public health implications.

AB - Background Prior studies on the depression-heart disease association have not usually used diagnostic measures of depression, or taken other mental disorders into consideration. As a result, it is not clear whether the association between depression and heart disease onset reflects a specific association, or the comorbidity between depression and other mental disorders. Additionally, the relative magnitude of associations of a range of mental disorders with heart disease onset is unknown. Methods Face-to-face household surveys were conducted in 19 countries (n = 52,095; person years = 2,141,194). The Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of 16 DSM-IV mental disorders. Heart disease was indicated by self-report of physician's diagnosis, or self-report of heart attack, together with their timing (year). Survival analyses estimated associations between first onset of mental disorders and subsequent heart disease onset. Results After comorbidity adjustment, depression, panic disorder, specific phobia, post-traumatic stress disorder and alcohol use disorders were associated with heart disease onset (ORs 1.3-1.6). Increasing number of mental disorders was associated with heart disease in a dose-response fashion. Mood disorders and alcohol abuse were more strongly associated with earlier onset than later onset heart disease. Associations did not vary by gender. Conclusions Depression, anxiety and alcohol use disorders were significantly associated with heart disease onset; depression was the weakest predictor. If confirmed in future prospective studies, the breadth of psychopathology's links with heart disease onset has substantial clinical and public health implications.

KW - Alcohol abuse

KW - Anxiety disorders

KW - Comorbidity

KW - Depression

KW - Heart disease

UR - http://www.scopus.com/inward/record.url?scp=84887135179&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887135179&partnerID=8YFLogxK

U2 - 10.1016/j.ijcard.2013.08.012

DO - 10.1016/j.ijcard.2013.08.012

M3 - Article

C2 - 23993321

AN - SCOPUS:84887135179

VL - 168

SP - 5293

EP - 5299

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

IS - 6

ER -