Abstract
Objective: Recent research demonstrating concurrent associations between mental disorders and peptic ulcers has renewed interest in links between psychological factors and ulcers. However, little is known about associations between temporally prior mental disorders and subsequent ulcer onset. Nor has the potentially confounding role of childhood adversities been explored. The objective of this study was to examine associations between a wide range of temporally prior DSM-IV mental disorders and subsequent onset of ulcer, without and with adjustment for mental disorder comorbidity and childhood adversities. Methods: Face-to-face household surveys conducted in 19 countries (n. = 52,095; person years. = 2,096,486). The Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of 16 DSM-IV mental disorders. Peptic ulcer onset was assessed in the same interview by self-report of physician's diagnosis and year of diagnosis. Survival analyses estimated associations between first onset of mental disorders and subsequent ulcer onset. Results: After comorbidity and sociodemographic adjustment, depression, social phobia, specific phobia, post-traumatic stress disorder, intermittent explosive disorder, alcohol and drug abuse disorders were significantly associated with ulcer onset (ORs 1.3-1.6). Increasing number of lifetime mental disorders was associated with ulcer onset in a dose-response fashion. These associations were only slightly attenuated by adjustment for childhood adversities. Conclusions: A wide range of mental disorders were linked with the self-report of subsequent peptic ulcer onset. These associations require confirmation in prospective designs, but are suggestive of a role for mental disorders in contributing to ulcer vulnerability, possibly through abnormalities in the physiological stress response associated with mental disorders.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 121-127 |
| Number of pages | 7 |
| Journal | Journal of Psychosomatic Research |
| Volume | 75 |
| Issue number | 2 |
| DOIs | |
| State | Published - Aug 2013 |
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Keywords
- Alcohol abuse and dependence
- Anxiety
- Depression
- Mental disorders
- Peptic ulcer
ASJC Scopus subject areas
- Psychiatry and Mental health
- Clinical Psychology
Cite this
Associations between DSM-IV mental disorders and onset of self-reported peptic ulcer in the World Mental Health Surveys. / Scott, Kate M.; Alonso, Jordi; de Jonge, Peter; Viana, Maria Carmen; Liu, Zhaorui; O'Neill, Siobhan; Aguilar-Gaxiola, Sergio; Bruffaerts, Ronny; Caldas-de-Almeida, Jose Miguel; Stein, Dan J.; Angermeyer, Matthias; Benjet, Corina; de Girolamo, Giovanni; Firuleasa, Ingrid Laura; Hu, Chiyi; Kiejna, Andrzej; Kovess-Masfety, Viviane; Levinson, Daphna; Nakane, Yoshibumi; Piazza, Marina; Posada-Villa, José A.; Khalaf, Mohammad Salih; Lim, Carmen C W; Kessler, Ronald C.
In: Journal of Psychosomatic Research, Vol. 75, No. 2, 08.2013, p. 121-127.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Associations between DSM-IV mental disorders and onset of self-reported peptic ulcer in the World Mental Health Surveys
AU - Scott, Kate M.
AU - Alonso, Jordi
AU - de Jonge, Peter
AU - Viana, Maria Carmen
AU - Liu, Zhaorui
AU - O'Neill, Siobhan
AU - Aguilar-Gaxiola, Sergio
AU - Bruffaerts, Ronny
AU - Caldas-de-Almeida, Jose Miguel
AU - Stein, Dan J.
AU - Angermeyer, Matthias
AU - Benjet, Corina
AU - de Girolamo, Giovanni
AU - Firuleasa, Ingrid Laura
AU - Hu, Chiyi
AU - Kiejna, Andrzej
AU - Kovess-Masfety, Viviane
AU - Levinson, Daphna
AU - Nakane, Yoshibumi
AU - Piazza, Marina
AU - Posada-Villa, José A.
AU - Khalaf, Mohammad Salih
AU - Lim, Carmen C W
AU - Kessler, Ronald C.
PY - 2013/8
Y1 - 2013/8
N2 - Objective: Recent research demonstrating concurrent associations between mental disorders and peptic ulcers has renewed interest in links between psychological factors and ulcers. However, little is known about associations between temporally prior mental disorders and subsequent ulcer onset. Nor has the potentially confounding role of childhood adversities been explored. The objective of this study was to examine associations between a wide range of temporally prior DSM-IV mental disorders and subsequent onset of ulcer, without and with adjustment for mental disorder comorbidity and childhood adversities. Methods: Face-to-face household surveys conducted in 19 countries (n. = 52,095; person years. = 2,096,486). The Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of 16 DSM-IV mental disorders. Peptic ulcer onset was assessed in the same interview by self-report of physician's diagnosis and year of diagnosis. Survival analyses estimated associations between first onset of mental disorders and subsequent ulcer onset. Results: After comorbidity and sociodemographic adjustment, depression, social phobia, specific phobia, post-traumatic stress disorder, intermittent explosive disorder, alcohol and drug abuse disorders were significantly associated with ulcer onset (ORs 1.3-1.6). Increasing number of lifetime mental disorders was associated with ulcer onset in a dose-response fashion. These associations were only slightly attenuated by adjustment for childhood adversities. Conclusions: A wide range of mental disorders were linked with the self-report of subsequent peptic ulcer onset. These associations require confirmation in prospective designs, but are suggestive of a role for mental disorders in contributing to ulcer vulnerability, possibly through abnormalities in the physiological stress response associated with mental disorders.
AB - Objective: Recent research demonstrating concurrent associations between mental disorders and peptic ulcers has renewed interest in links between psychological factors and ulcers. However, little is known about associations between temporally prior mental disorders and subsequent ulcer onset. Nor has the potentially confounding role of childhood adversities been explored. The objective of this study was to examine associations between a wide range of temporally prior DSM-IV mental disorders and subsequent onset of ulcer, without and with adjustment for mental disorder comorbidity and childhood adversities. Methods: Face-to-face household surveys conducted in 19 countries (n. = 52,095; person years. = 2,096,486). The Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of 16 DSM-IV mental disorders. Peptic ulcer onset was assessed in the same interview by self-report of physician's diagnosis and year of diagnosis. Survival analyses estimated associations between first onset of mental disorders and subsequent ulcer onset. Results: After comorbidity and sociodemographic adjustment, depression, social phobia, specific phobia, post-traumatic stress disorder, intermittent explosive disorder, alcohol and drug abuse disorders were significantly associated with ulcer onset (ORs 1.3-1.6). Increasing number of lifetime mental disorders was associated with ulcer onset in a dose-response fashion. These associations were only slightly attenuated by adjustment for childhood adversities. Conclusions: A wide range of mental disorders were linked with the self-report of subsequent peptic ulcer onset. These associations require confirmation in prospective designs, but are suggestive of a role for mental disorders in contributing to ulcer vulnerability, possibly through abnormalities in the physiological stress response associated with mental disorders.
KW - Alcohol abuse and dependence
KW - Anxiety
KW - Depression
KW - Mental disorders
KW - Peptic ulcer
UR - http://www.scopus.com/inward/record.url?scp=84881025402&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84881025402&partnerID=8YFLogxK
U2 - 10.1016/j.jpsychores.2013.04.007
DO - 10.1016/j.jpsychores.2013.04.007
M3 - Article
C2 - 23915767
AN - SCOPUS:84881025402
VL - 75
SP - 121
EP - 127
JO - Journal of Psychosomatic Research
JF - Journal of Psychosomatic Research
SN - 0022-3999
IS - 2
ER -