Associations between DSM-IV mental disorders and onset of self-reported peptic ulcer in the World Mental Health Surveys

Kate M. Scott, Jordi Alonso, Peter de Jonge, Maria Carmen Viana, Zhaorui Liu, Siobhan O'Neill, Sergio Aguilar-Gaxiola, Ronny Bruffaerts, Jose Miguel Caldas-de-Almeida, Dan J. Stein, Matthias Angermeyer, Corina Benjet, Giovanni de Girolamo, Ingrid Laura Firuleasa, Chiyi Hu, Andrzej Kiejna, Viviane Kovess-Masfety, Daphna Levinson, Yoshibumi Nakane, Marina PiazzaJosé A. Posada-Villa, Mohammad Salih Khalaf, Carmen C W Lim, Ronald C. Kessler

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: Recent research demonstrating concurrent associations between mental disorders and peptic ulcers has renewed interest in links between psychological factors and ulcers. However, little is known about associations between temporally prior mental disorders and subsequent ulcer onset. Nor has the potentially confounding role of childhood adversities been explored. The objective of this study was to examine associations between a wide range of temporally prior DSM-IV mental disorders and subsequent onset of ulcer, without and with adjustment for mental disorder comorbidity and childhood adversities. Methods: Face-to-face household surveys conducted in 19 countries (n. = 52,095; person years. = 2,096,486). The Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of 16 DSM-IV mental disorders. Peptic ulcer onset was assessed in the same interview by self-report of physician's diagnosis and year of diagnosis. Survival analyses estimated associations between first onset of mental disorders and subsequent ulcer onset. Results: After comorbidity and sociodemographic adjustment, depression, social phobia, specific phobia, post-traumatic stress disorder, intermittent explosive disorder, alcohol and drug abuse disorders were significantly associated with ulcer onset (ORs 1.3-1.6). Increasing number of lifetime mental disorders was associated with ulcer onset in a dose-response fashion. These associations were only slightly attenuated by adjustment for childhood adversities. Conclusions: A wide range of mental disorders were linked with the self-report of subsequent peptic ulcer onset. These associations require confirmation in prospective designs, but are suggestive of a role for mental disorders in contributing to ulcer vulnerability, possibly through abnormalities in the physiological stress response associated with mental disorders.

Original languageEnglish (US)
Pages (from-to)121-127
Number of pages7
JournalJournal of Psychosomatic Research
Volume75
Issue number2
DOIs
StatePublished - Aug 2013

Fingerprint

Health Surveys
Peptic Ulcer
Mental Disorders
Diagnostic and Statistical Manual of Mental Disorders
Mental Health
Ulcer
Self Report
Comorbidity
Global Health
Disruptive, Impulse Control, and Conduct Disorders
Interviews
Adjustment Disorders
Social Adjustment
Physiological Stress
Survival Analysis
Post-Traumatic Stress Disorders
Age of Onset
Alcoholism
Substance-Related Disorders
Depression

Keywords

  • Alcohol abuse and dependence
  • Anxiety
  • Depression
  • Mental disorders
  • Peptic ulcer

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Associations between DSM-IV mental disorders and onset of self-reported peptic ulcer in the World Mental Health Surveys. / Scott, Kate M.; Alonso, Jordi; de Jonge, Peter; Viana, Maria Carmen; Liu, Zhaorui; O'Neill, Siobhan; Aguilar-Gaxiola, Sergio; Bruffaerts, Ronny; Caldas-de-Almeida, Jose Miguel; Stein, Dan J.; Angermeyer, Matthias; Benjet, Corina; de Girolamo, Giovanni; Firuleasa, Ingrid Laura; Hu, Chiyi; Kiejna, Andrzej; Kovess-Masfety, Viviane; Levinson, Daphna; Nakane, Yoshibumi; Piazza, Marina; Posada-Villa, José A.; Khalaf, Mohammad Salih; Lim, Carmen C W; Kessler, Ronald C.

In: Journal of Psychosomatic Research, Vol. 75, No. 2, 08.2013, p. 121-127.

Research output: Contribution to journalArticle

Scott, KM, Alonso, J, de Jonge, P, Viana, MC, Liu, Z, O'Neill, S, Aguilar-Gaxiola, S, Bruffaerts, R, Caldas-de-Almeida, JM, Stein, DJ, Angermeyer, M, Benjet, C, de Girolamo, G, Firuleasa, IL, Hu, C, Kiejna, A, Kovess-Masfety, V, Levinson, D, Nakane, Y, Piazza, M, Posada-Villa, JA, Khalaf, MS, Lim, CCW & Kessler, RC 2013, 'Associations between DSM-IV mental disorders and onset of self-reported peptic ulcer in the World Mental Health Surveys', Journal of Psychosomatic Research, vol. 75, no. 2, pp. 121-127. https://doi.org/10.1016/j.jpsychores.2013.04.007
Scott, Kate M. ; Alonso, Jordi ; de Jonge, Peter ; Viana, Maria Carmen ; Liu, Zhaorui ; O'Neill, Siobhan ; Aguilar-Gaxiola, Sergio ; Bruffaerts, Ronny ; Caldas-de-Almeida, Jose Miguel ; Stein, Dan J. ; Angermeyer, Matthias ; Benjet, Corina ; de Girolamo, Giovanni ; Firuleasa, Ingrid Laura ; Hu, Chiyi ; Kiejna, Andrzej ; Kovess-Masfety, Viviane ; Levinson, Daphna ; Nakane, Yoshibumi ; Piazza, Marina ; Posada-Villa, José A. ; Khalaf, Mohammad Salih ; Lim, Carmen C W ; Kessler, Ronald C. / Associations between DSM-IV mental disorders and onset of self-reported peptic ulcer in the World Mental Health Surveys. In: Journal of Psychosomatic Research. 2013 ; Vol. 75, No. 2. pp. 121-127.
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abstract = "Objective: Recent research demonstrating concurrent associations between mental disorders and peptic ulcers has renewed interest in links between psychological factors and ulcers. However, little is known about associations between temporally prior mental disorders and subsequent ulcer onset. Nor has the potentially confounding role of childhood adversities been explored. The objective of this study was to examine associations between a wide range of temporally prior DSM-IV mental disorders and subsequent onset of ulcer, without and with adjustment for mental disorder comorbidity and childhood adversities. Methods: Face-to-face household surveys conducted in 19 countries (n. = 52,095; person years. = 2,096,486). The Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of 16 DSM-IV mental disorders. Peptic ulcer onset was assessed in the same interview by self-report of physician's diagnosis and year of diagnosis. Survival analyses estimated associations between first onset of mental disorders and subsequent ulcer onset. Results: After comorbidity and sociodemographic adjustment, depression, social phobia, specific phobia, post-traumatic stress disorder, intermittent explosive disorder, alcohol and drug abuse disorders were significantly associated with ulcer onset (ORs 1.3-1.6). Increasing number of lifetime mental disorders was associated with ulcer onset in a dose-response fashion. These associations were only slightly attenuated by adjustment for childhood adversities. Conclusions: A wide range of mental disorders were linked with the self-report of subsequent peptic ulcer onset. These associations require confirmation in prospective designs, but are suggestive of a role for mental disorders in contributing to ulcer vulnerability, possibly through abnormalities in the physiological stress response associated with mental disorders.",
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AU - Scott, Kate M.

AU - Alonso, Jordi

AU - de Jonge, Peter

AU - Viana, Maria Carmen

AU - Liu, Zhaorui

AU - O'Neill, Siobhan

AU - Aguilar-Gaxiola, Sergio

AU - Bruffaerts, Ronny

AU - Caldas-de-Almeida, Jose Miguel

AU - Stein, Dan J.

AU - Angermeyer, Matthias

AU - Benjet, Corina

AU - de Girolamo, Giovanni

AU - Firuleasa, Ingrid Laura

AU - Hu, Chiyi

AU - Kiejna, Andrzej

AU - Kovess-Masfety, Viviane

AU - Levinson, Daphna

AU - Nakane, Yoshibumi

AU - Piazza, Marina

AU - Posada-Villa, José A.

AU - Khalaf, Mohammad Salih

AU - Lim, Carmen C W

AU - Kessler, Ronald C.

PY - 2013/8

Y1 - 2013/8

N2 - Objective: Recent research demonstrating concurrent associations between mental disorders and peptic ulcers has renewed interest in links between psychological factors and ulcers. However, little is known about associations between temporally prior mental disorders and subsequent ulcer onset. Nor has the potentially confounding role of childhood adversities been explored. The objective of this study was to examine associations between a wide range of temporally prior DSM-IV mental disorders and subsequent onset of ulcer, without and with adjustment for mental disorder comorbidity and childhood adversities. Methods: Face-to-face household surveys conducted in 19 countries (n. = 52,095; person years. = 2,096,486). The Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of 16 DSM-IV mental disorders. Peptic ulcer onset was assessed in the same interview by self-report of physician's diagnosis and year of diagnosis. Survival analyses estimated associations between first onset of mental disorders and subsequent ulcer onset. Results: After comorbidity and sociodemographic adjustment, depression, social phobia, specific phobia, post-traumatic stress disorder, intermittent explosive disorder, alcohol and drug abuse disorders were significantly associated with ulcer onset (ORs 1.3-1.6). Increasing number of lifetime mental disorders was associated with ulcer onset in a dose-response fashion. These associations were only slightly attenuated by adjustment for childhood adversities. Conclusions: A wide range of mental disorders were linked with the self-report of subsequent peptic ulcer onset. These associations require confirmation in prospective designs, but are suggestive of a role for mental disorders in contributing to ulcer vulnerability, possibly through abnormalities in the physiological stress response associated with mental disorders.

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KW - Alcohol abuse and dependence

KW - Anxiety

KW - Depression

KW - Mental disorders

KW - Peptic ulcer

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