Abstract
The Functional Activities Questionnaire (FAQ) and Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) are frequently used indices of cognitive decline in Alzheimer's disease (AD). The goal of this study was to compare FDG-PET and clinical measurements in a large sample of elderly subjects with memory disturbance. We examined relationships between glucose metabolism in FDG-PET regions of interest (FDG-ROIs), and ADAS-cog and FAQ scores in AD and mild cognitive impairment (MCI) patients enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Low glucose metabolism at baseline predicted subsequent ADAS-cog and FAQ decline. In addition, longitudinal glucose metabolism decline was associated with concurrent ADAS-cog and FAQ decline. Finally, a power analysis revealed that FDG-ROI values have greater statistical power than ADAS-cog to detect attenuation of cognitive decline in AD and MCI patients. Glucose metabolism is a sensitive measure of change in cognition and functional ability in AD and MCI, and has value in predicting future cognitive decline.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1207-1218 |
| Number of pages | 12 |
| Journal | Neurobiology of Aging |
| Volume | 32 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2011 |
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Keywords
- Alzheimer's disease
- FDG-PET
- Mild cognitive impairment
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
- Aging
- Developmental Biology
- Geriatrics and Gerontology
Cite this
Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI. / Landau, Susan M.; Harvey, Danielle J; Madison, Cindee M.; Koeppe, Robert A.; Reiman, Eric M.; Foster, Norman L.; Weiner, Michael W.; Jagust, William J.
In: Neurobiology of Aging, Vol. 32, No. 7, 07.2011, p. 1207-1218.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI
AU - Landau, Susan M.
AU - Harvey, Danielle J
AU - Madison, Cindee M.
AU - Koeppe, Robert A.
AU - Reiman, Eric M.
AU - Foster, Norman L.
AU - Weiner, Michael W.
AU - Jagust, William J.
PY - 2011/7
Y1 - 2011/7
N2 - The Functional Activities Questionnaire (FAQ) and Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) are frequently used indices of cognitive decline in Alzheimer's disease (AD). The goal of this study was to compare FDG-PET and clinical measurements in a large sample of elderly subjects with memory disturbance. We examined relationships between glucose metabolism in FDG-PET regions of interest (FDG-ROIs), and ADAS-cog and FAQ scores in AD and mild cognitive impairment (MCI) patients enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Low glucose metabolism at baseline predicted subsequent ADAS-cog and FAQ decline. In addition, longitudinal glucose metabolism decline was associated with concurrent ADAS-cog and FAQ decline. Finally, a power analysis revealed that FDG-ROI values have greater statistical power than ADAS-cog to detect attenuation of cognitive decline in AD and MCI patients. Glucose metabolism is a sensitive measure of change in cognition and functional ability in AD and MCI, and has value in predicting future cognitive decline.
AB - The Functional Activities Questionnaire (FAQ) and Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) are frequently used indices of cognitive decline in Alzheimer's disease (AD). The goal of this study was to compare FDG-PET and clinical measurements in a large sample of elderly subjects with memory disturbance. We examined relationships between glucose metabolism in FDG-PET regions of interest (FDG-ROIs), and ADAS-cog and FAQ scores in AD and mild cognitive impairment (MCI) patients enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Low glucose metabolism at baseline predicted subsequent ADAS-cog and FAQ decline. In addition, longitudinal glucose metabolism decline was associated with concurrent ADAS-cog and FAQ decline. Finally, a power analysis revealed that FDG-ROI values have greater statistical power than ADAS-cog to detect attenuation of cognitive decline in AD and MCI patients. Glucose metabolism is a sensitive measure of change in cognition and functional ability in AD and MCI, and has value in predicting future cognitive decline.
KW - Alzheimer's disease
KW - FDG-PET
KW - Mild cognitive impairment
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UR - http://www.scopus.com/inward/citedby.url?scp=79958766587&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2009.07.002
DO - 10.1016/j.neurobiolaging.2009.07.002
M3 - Article
C2 - 19660834
AN - SCOPUS:79958766587
VL - 32
SP - 1207
EP - 1218
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 7
ER -