Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI

Susan M. Landau; Danielle J Harvey; Cindee M. Madison; Robert A. Koeppe; Eric M. Reiman; Norman L. Foster; Michael W. Weiner; William J. Jagust

doi:10.1016/j.neurobiolaging.2009.07.002

Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI

Susan M. Landau, Danielle J Harvey, Cindee M. Madison, Robert A. Koeppe, Eric M. Reiman, Norman L. Foster, Michael W. Weiner, William J. Jagust

Public Health Sciences

Research output: Contribution to journal › Article

348 Scopus citations

Abstract

The Functional Activities Questionnaire (FAQ) and Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) are frequently used indices of cognitive decline in Alzheimer's disease (AD). The goal of this study was to compare FDG-PET and clinical measurements in a large sample of elderly subjects with memory disturbance. We examined relationships between glucose metabolism in FDG-PET regions of interest (FDG-ROIs), and ADAS-cog and FAQ scores in AD and mild cognitive impairment (MCI) patients enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Low glucose metabolism at baseline predicted subsequent ADAS-cog and FAQ decline. In addition, longitudinal glucose metabolism decline was associated with concurrent ADAS-cog and FAQ decline. Finally, a power analysis revealed that FDG-ROI values have greater statistical power than ADAS-cog to detect attenuation of cognitive decline in AD and MCI patients. Glucose metabolism is a sensitive measure of change in cognition and functional ability in AD and MCI, and has value in predicting future cognitive decline.

Original language	English (US)
Pages (from-to)	1207-1218
Number of pages	12
Journal	Neurobiology of Aging
Volume	32
Issue number	7
DOIs	https://doi.org/10.1016/j.neurobiolaging.2009.07.002
State	Published - Jul 2011

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Keywords

Alzheimer's disease
FDG-PET
Mild cognitive impairment

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)
Aging
Developmental Biology
Geriatrics and Gerontology

Cite this

Landau, S. M., Harvey, D. J., Madison, C. M., Koeppe, R. A., Reiman, E. M., Foster, N. L., Weiner, M. W., & Jagust, W. J. (2011). Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI. Neurobiology of Aging, 32(7), 1207-1218. https://doi.org/10.1016/j.neurobiolaging.2009.07.002

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abstract = "The Functional Activities Questionnaire (FAQ) and Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) are frequently used indices of cognitive decline in Alzheimer's disease (AD). The goal of this study was to compare FDG-PET and clinical measurements in a large sample of elderly subjects with memory disturbance. We examined relationships between glucose metabolism in FDG-PET regions of interest (FDG-ROIs), and ADAS-cog and FAQ scores in AD and mild cognitive impairment (MCI) patients enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Low glucose metabolism at baseline predicted subsequent ADAS-cog and FAQ decline. In addition, longitudinal glucose metabolism decline was associated with concurrent ADAS-cog and FAQ decline. Finally, a power analysis revealed that FDG-ROI values have greater statistical power than ADAS-cog to detect attenuation of cognitive decline in AD and MCI patients. Glucose metabolism is a sensitive measure of change in cognition and functional ability in AD and MCI, and has value in predicting future cognitive decline.",

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author = "Landau, {Susan M.} and Harvey, {Danielle J} and Madison, {Cindee M.} and Koeppe, {Robert A.} and Reiman, {Eric M.} and Foster, {Norman L.} and Weiner, {Michael W.} and Jagust, {William J.}",

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Access to Document

10.1016/j.neurobiolaging.2009.07.002