Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI

Susan M. Landau, Danielle J Harvey, Cindee M. Madison, Robert A. Koeppe, Eric M. Reiman, Norman L. Foster, Michael W. Weiner, William J. Jagust

Research output: Contribution to journalArticle

370 Scopus citations

Abstract

The Functional Activities Questionnaire (FAQ) and Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) are frequently used indices of cognitive decline in Alzheimer's disease (AD). The goal of this study was to compare FDG-PET and clinical measurements in a large sample of elderly subjects with memory disturbance. We examined relationships between glucose metabolism in FDG-PET regions of interest (FDG-ROIs), and ADAS-cog and FAQ scores in AD and mild cognitive impairment (MCI) patients enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Low glucose metabolism at baseline predicted subsequent ADAS-cog and FAQ decline. In addition, longitudinal glucose metabolism decline was associated with concurrent ADAS-cog and FAQ decline. Finally, a power analysis revealed that FDG-ROI values have greater statistical power than ADAS-cog to detect attenuation of cognitive decline in AD and MCI patients. Glucose metabolism is a sensitive measure of change in cognition and functional ability in AD and MCI, and has value in predicting future cognitive decline.

Original languageEnglish (US)
Pages (from-to)1207-1218
Number of pages12
JournalNeurobiology of Aging
Volume32
Issue number7
DOIs
StatePublished - Jul 2011

Keywords

  • Alzheimer's disease
  • FDG-PET
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology

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    Landau, S. M., Harvey, D. J., Madison, C. M., Koeppe, R. A., Reiman, E. M., Foster, N. L., Weiner, M. W., & Jagust, W. J. (2011). Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI. Neurobiology of Aging, 32(7), 1207-1218. https://doi.org/10.1016/j.neurobiolaging.2009.07.002