Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI

Susan M. Landau, Danielle J Harvey, Cindee M. Madison, Robert A. Koeppe, Eric M. Reiman, Norman L. Foster, Michael W. Weiner, William J. Jagust

Research output: Contribution to journalArticle

338 Citations (Scopus)

Abstract

The Functional Activities Questionnaire (FAQ) and Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) are frequently used indices of cognitive decline in Alzheimer's disease (AD). The goal of this study was to compare FDG-PET and clinical measurements in a large sample of elderly subjects with memory disturbance. We examined relationships between glucose metabolism in FDG-PET regions of interest (FDG-ROIs), and ADAS-cog and FAQ scores in AD and mild cognitive impairment (MCI) patients enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Low glucose metabolism at baseline predicted subsequent ADAS-cog and FAQ decline. In addition, longitudinal glucose metabolism decline was associated with concurrent ADAS-cog and FAQ decline. Finally, a power analysis revealed that FDG-ROI values have greater statistical power than ADAS-cog to detect attenuation of cognitive decline in AD and MCI patients. Glucose metabolism is a sensitive measure of change in cognition and functional ability in AD and MCI, and has value in predicting future cognitive decline.

Original languageEnglish (US)
Pages (from-to)1207-1218
Number of pages12
JournalNeurobiology of Aging
Volume32
Issue number7
DOIs
StatePublished - Jul 2011

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Alzheimer Disease
Glucose
Cognitive Dysfunction
Aptitude
Neuroimaging
Cognition
Surveys and Questionnaires

Keywords

  • Alzheimer's disease
  • FDG-PET
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Landau, S. M., Harvey, D. J., Madison, C. M., Koeppe, R. A., Reiman, E. M., Foster, N. L., ... Jagust, W. J. (2011). Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI. Neurobiology of Aging, 32(7), 1207-1218. https://doi.org/10.1016/j.neurobiolaging.2009.07.002

Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI. / Landau, Susan M.; Harvey, Danielle J; Madison, Cindee M.; Koeppe, Robert A.; Reiman, Eric M.; Foster, Norman L.; Weiner, Michael W.; Jagust, William J.

In: Neurobiology of Aging, Vol. 32, No. 7, 07.2011, p. 1207-1218.

Research output: Contribution to journalArticle

Landau, SM, Harvey, DJ, Madison, CM, Koeppe, RA, Reiman, EM, Foster, NL, Weiner, MW & Jagust, WJ 2011, 'Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI', Neurobiology of Aging, vol. 32, no. 7, pp. 1207-1218. https://doi.org/10.1016/j.neurobiolaging.2009.07.002
Landau, Susan M. ; Harvey, Danielle J ; Madison, Cindee M. ; Koeppe, Robert A. ; Reiman, Eric M. ; Foster, Norman L. ; Weiner, Michael W. ; Jagust, William J. / Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI. In: Neurobiology of Aging. 2011 ; Vol. 32, No. 7. pp. 1207-1218.
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