Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI

Susan M. Landau; Danielle J Harvey; Cindee M. Madison; Robert A. Koeppe; Eric M. Reiman; Norman L. Foster; Michael W. Weiner; William J. Jagust

doi:10.1016/j.neurobiolaging.2009.07.002

Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI

Susan M. Landau, Danielle J Harvey, Cindee M. Madison, Robert A. Koeppe, Eric M. Reiman, Norman L. Foster, Michael W. Weiner, William J. Jagust

Public Health Sciences

Research output: Contribution to journal › Article › peer-review

390 Scopus citations

Abstract

The Functional Activities Questionnaire (FAQ) and Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) are frequently used indices of cognitive decline in Alzheimer's disease (AD). The goal of this study was to compare FDG-PET and clinical measurements in a large sample of elderly subjects with memory disturbance. We examined relationships between glucose metabolism in FDG-PET regions of interest (FDG-ROIs), and ADAS-cog and FAQ scores in AD and mild cognitive impairment (MCI) patients enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Low glucose metabolism at baseline predicted subsequent ADAS-cog and FAQ decline. In addition, longitudinal glucose metabolism decline was associated with concurrent ADAS-cog and FAQ decline. Finally, a power analysis revealed that FDG-ROI values have greater statistical power than ADAS-cog to detect attenuation of cognitive decline in AD and MCI patients. Glucose metabolism is a sensitive measure of change in cognition and functional ability in AD and MCI, and has value in predicting future cognitive decline.

Original language	English (US)
Pages (from-to)	1207-1218
Number of pages	12
Journal	Neurobiology of Aging
Volume	32
Issue number	7
DOIs	https://doi.org/10.1016/j.neurobiolaging.2009.07.002
State	Published - Jul 2011

Keywords

Alzheimer's disease
FDG-PET
Mild cognitive impairment

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)
Aging
Developmental Biology
Geriatrics and Gerontology

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Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI. / Landau, Susan M.; Harvey, Danielle J; Madison, Cindee M.; Koeppe, Robert A.; Reiman, Eric M.; Foster, Norman L.; Weiner, Michael W.; Jagust, William J.

In: Neurobiology of Aging, Vol. 32, No. 7, 07.2011, p. 1207-1218.

Research output: Contribution to journal › Article › peer-review

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abstract = "The Functional Activities Questionnaire (FAQ) and Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) are frequently used indices of cognitive decline in Alzheimer's disease (AD). The goal of this study was to compare FDG-PET and clinical measurements in a large sample of elderly subjects with memory disturbance. We examined relationships between glucose metabolism in FDG-PET regions of interest (FDG-ROIs), and ADAS-cog and FAQ scores in AD and mild cognitive impairment (MCI) patients enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Low glucose metabolism at baseline predicted subsequent ADAS-cog and FAQ decline. In addition, longitudinal glucose metabolism decline was associated with concurrent ADAS-cog and FAQ decline. Finally, a power analysis revealed that FDG-ROI values have greater statistical power than ADAS-cog to detect attenuation of cognitive decline in AD and MCI patients. Glucose metabolism is a sensitive measure of change in cognition and functional ability in AD and MCI, and has value in predicting future cognitive decline.",

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