Associations among vascular risk factors, neuroimaging biomarkers, and cognition: Preliminary analyses from the Multi-Ethnic Study of Atherosclerosis (MESA)

Samuel N. Lockhart, Christopher L. Schaich, Suzanne Craft, Bonnie C. Sachs, Stephen R. Rapp, Youngkyoo Jung, Christopher T. Whitlow, Kiran Kumar Solingapuram Sai, Maryjo Cleveland, Benjamin J. Williams, Gregory L. Burke, Alain Bertoni, Kathleen M. Hayden, Timothy M. Hughes

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Little is known about how antecedent vascular risk factor (VRF) profiles impact late-life brain health. Methods: We examined baseline VRFs, and cognitive testing and neuroimaging measures (β-amyloid [Aβ] PET, MRI) in a diverse longitudinal cohort (N = 159; 50% African-American, 50% White) from Wake Forest's Multi-Ethnic Study of Atherosclerosis Core. Results: African-Americans exhibited greater baseline Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE), Framingham stroke risk profile (FSRP), and atherosclerotic cardiovascular disease risk estimate (ASCVD) scores than Whites. We observed no significant racial differences in Aβ positivity, cortical thickness, or white matter hyperintensity (WMH) volume. Higher baseline VRF scores were associated with lower cortical thickness and greater WMH volume, and FSRP and CAIDE were associated with Aβ. Aβ was cross-sectionally associated with cognition, and all imaging biomarkers were associated with greater 6-year cognitive decline. Discussion: Results suggest the convergence of multiple vascular and Alzheimer's processes underlying neurodegeneration and cognitive decline.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
DOIs
StateAccepted/In press - 2021

Keywords

  • aging
  • cognition
  • magnetic resonance imaging
  • positron emission tomography
  • vascular risk factors

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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