Abstract
Objectives: Fatty acid profiles and desaturase (SCD-16, SCD018, D5D, D6D) and elongase (ELOVL6) enzyme activity have been associated with adiposity and metabolic disease. While this has been studied in adults, few studies have included children. The objective of this study was to evaluate these markers in children and identify relationships with markers of metabolic health. It was hypothesized that these lipid markers would be correlated to adiposity and metabolic disease. Methods: This study was a cross-sectional analysis of fourth- and fifth-grade children (n = 86, aged 9–12) participating in a comprehensive nutrition program. Any student enrolled in the program was eligible for inclusion in this study. Fasting plasma was collected and analyzed for total fatty acids, glucose, insulin, and full lipid panels. Insulin resistance was estimated using calculated homeostatic model assessment for insulin resistance (HOMA-IR) values. Results: There were no differences in lipid markers, glucose, insulin, or HOMA-IR among children classified as normal weight, overweight, or obese. SCD-16, D5D, and ELOVL6 activity was significantly correlated to HOMA-IR values (r = 0.39, p = 0.001; r = −0.33, p = 0.006; r = −0.37, p = 0.005, respectively). In regression analysis, body mass index for age percentile, D6D activity, ELOVL6 activity, and systolic blood pressure were the most significant predictors of HOMA-IR values (adjusted r2 = 0.39, p ≤ 0.001). Conclusions: There was no relationship between these lipid markers and adiposity in this population; however, there were correlations with HOMA-IR. Regardless of adiposity, there may be underlying changes in fatty acid and lipid metabolism associated with the development of metabolic diseases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-7 |
| Number of pages | 7 |
| Journal | Journal of the American College of Nutrition |
| DOIs | |
| State | Accepted/In press - Sep 15 2017 |
Fingerprint
Keywords
- Childhood obesity
- desaturase activity
- elongase activity
- insulin resistance
- lipid biomarker
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
Cite this
Associations Among Fatty Acids, Desaturase and Elongase, and Insulin Resistance in Children. / Beccarelli, Lori M.; Scherr, Rachel Erin; Newman, John W.; Borkowska, Alison G.; Gray, Ira J.; Linnell, Jessica D.; Keen, Carl L; Young, Heather M.
In: Journal of the American College of Nutrition, 15.09.2017, p. 1-7.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Associations Among Fatty Acids, Desaturase and Elongase, and Insulin Resistance in Children
AU - Beccarelli, Lori M.
AU - Scherr, Rachel Erin
AU - Newman, John W.
AU - Borkowska, Alison G.
AU - Gray, Ira J.
AU - Linnell, Jessica D.
AU - Keen, Carl L
AU - Young, Heather M
PY - 2017/9/15
Y1 - 2017/9/15
N2 - Objectives: Fatty acid profiles and desaturase (SCD-16, SCD018, D5D, D6D) and elongase (ELOVL6) enzyme activity have been associated with adiposity and metabolic disease. While this has been studied in adults, few studies have included children. The objective of this study was to evaluate these markers in children and identify relationships with markers of metabolic health. It was hypothesized that these lipid markers would be correlated to adiposity and metabolic disease. Methods: This study was a cross-sectional analysis of fourth- and fifth-grade children (n = 86, aged 9–12) participating in a comprehensive nutrition program. Any student enrolled in the program was eligible for inclusion in this study. Fasting plasma was collected and analyzed for total fatty acids, glucose, insulin, and full lipid panels. Insulin resistance was estimated using calculated homeostatic model assessment for insulin resistance (HOMA-IR) values. Results: There were no differences in lipid markers, glucose, insulin, or HOMA-IR among children classified as normal weight, overweight, or obese. SCD-16, D5D, and ELOVL6 activity was significantly correlated to HOMA-IR values (r = 0.39, p = 0.001; r = −0.33, p = 0.006; r = −0.37, p = 0.005, respectively). In regression analysis, body mass index for age percentile, D6D activity, ELOVL6 activity, and systolic blood pressure were the most significant predictors of HOMA-IR values (adjusted r2 = 0.39, p ≤ 0.001). Conclusions: There was no relationship between these lipid markers and adiposity in this population; however, there were correlations with HOMA-IR. Regardless of adiposity, there may be underlying changes in fatty acid and lipid metabolism associated with the development of metabolic diseases.
AB - Objectives: Fatty acid profiles and desaturase (SCD-16, SCD018, D5D, D6D) and elongase (ELOVL6) enzyme activity have been associated with adiposity and metabolic disease. While this has been studied in adults, few studies have included children. The objective of this study was to evaluate these markers in children and identify relationships with markers of metabolic health. It was hypothesized that these lipid markers would be correlated to adiposity and metabolic disease. Methods: This study was a cross-sectional analysis of fourth- and fifth-grade children (n = 86, aged 9–12) participating in a comprehensive nutrition program. Any student enrolled in the program was eligible for inclusion in this study. Fasting plasma was collected and analyzed for total fatty acids, glucose, insulin, and full lipid panels. Insulin resistance was estimated using calculated homeostatic model assessment for insulin resistance (HOMA-IR) values. Results: There were no differences in lipid markers, glucose, insulin, or HOMA-IR among children classified as normal weight, overweight, or obese. SCD-16, D5D, and ELOVL6 activity was significantly correlated to HOMA-IR values (r = 0.39, p = 0.001; r = −0.33, p = 0.006; r = −0.37, p = 0.005, respectively). In regression analysis, body mass index for age percentile, D6D activity, ELOVL6 activity, and systolic blood pressure were the most significant predictors of HOMA-IR values (adjusted r2 = 0.39, p ≤ 0.001). Conclusions: There was no relationship between these lipid markers and adiposity in this population; however, there were correlations with HOMA-IR. Regardless of adiposity, there may be underlying changes in fatty acid and lipid metabolism associated with the development of metabolic diseases.
KW - Childhood obesity
KW - desaturase activity
KW - elongase activity
KW - insulin resistance
KW - lipid biomarker
UR - http://www.scopus.com/inward/record.url?scp=85031728891&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85031728891&partnerID=8YFLogxK
U2 - 10.1080/07315724.2017.1347908
DO - 10.1080/07315724.2017.1347908
M3 - Article
C2 - 29043930
AN - SCOPUS:85031728891
SP - 1
EP - 7
JO - Journal of the American College of Nutrition
JF - Journal of the American College of Nutrition
SN - 0731-5724
ER -