Associations Among Fatty Acids, Desaturase and Elongase, and Insulin Resistance in Children

Lori M. Beccarelli, Rachel Erin Scherr, John W. Newman, Alison G. Borkowska, Ira J. Gray, Jessica D. Linnell, Carl L Keen, Heather M Young

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: Fatty acid profiles and desaturase (SCD-16, SCD018, D5D, D6D) and elongase (ELOVL6) enzyme activity have been associated with adiposity and metabolic disease. While this has been studied in adults, few studies have included children. The objective of this study was to evaluate these markers in children and identify relationships with markers of metabolic health. It was hypothesized that these lipid markers would be correlated to adiposity and metabolic disease. Methods: This study was a cross-sectional analysis of fourth- and fifth-grade children (n = 86, aged 9–12) participating in a comprehensive nutrition program. Any student enrolled in the program was eligible for inclusion in this study. Fasting plasma was collected and analyzed for total fatty acids, glucose, insulin, and full lipid panels. Insulin resistance was estimated using calculated homeostatic model assessment for insulin resistance (HOMA-IR) values. Results: There were no differences in lipid markers, glucose, insulin, or HOMA-IR among children classified as normal weight, overweight, or obese. SCD-16, D5D, and ELOVL6 activity was significantly correlated to HOMA-IR values (r = 0.39, p = 0.001; r = −0.33, p = 0.006; r = −0.37, p = 0.005, respectively). In regression analysis, body mass index for age percentile, D6D activity, ELOVL6 activity, and systolic blood pressure were the most significant predictors of HOMA-IR values (adjusted r2 = 0.39, p ≤ 0.001). Conclusions: There was no relationship between these lipid markers and adiposity in this population; however, there were correlations with HOMA-IR. Regardless of adiposity, there may be underlying changes in fatty acid and lipid metabolism associated with the development of metabolic diseases.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalJournal of the American College of Nutrition
DOIs
StateAccepted/In press - Sep 15 2017

Fingerprint

Fatty Acid Desaturases
Insulin Resistance
Adiposity
Metabolic Diseases
Lipids
Fatty Acids
Insulin
Blood Pressure
Glucose
Lipid Metabolism
fatty acid elongases
Fasting
Body Mass Index
Cross-Sectional Studies
Regression Analysis
Students
Weights and Measures
Health
Enzymes
Population

Keywords

  • Childhood obesity
  • desaturase activity
  • elongase activity
  • insulin resistance
  • lipid biomarker

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Associations Among Fatty Acids, Desaturase and Elongase, and Insulin Resistance in Children. / Beccarelli, Lori M.; Scherr, Rachel Erin; Newman, John W.; Borkowska, Alison G.; Gray, Ira J.; Linnell, Jessica D.; Keen, Carl L; Young, Heather M.

In: Journal of the American College of Nutrition, 15.09.2017, p. 1-7.

Research output: Contribution to journalArticle

Beccarelli, Lori M. ; Scherr, Rachel Erin ; Newman, John W. ; Borkowska, Alison G. ; Gray, Ira J. ; Linnell, Jessica D. ; Keen, Carl L ; Young, Heather M. / Associations Among Fatty Acids, Desaturase and Elongase, and Insulin Resistance in Children. In: Journal of the American College of Nutrition. 2017 ; pp. 1-7.
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AU - Beccarelli, Lori M.

AU - Scherr, Rachel Erin

AU - Newman, John W.

AU - Borkowska, Alison G.

AU - Gray, Ira J.

AU - Linnell, Jessica D.

AU - Keen, Carl L

AU - Young, Heather M

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AB - Objectives: Fatty acid profiles and desaturase (SCD-16, SCD018, D5D, D6D) and elongase (ELOVL6) enzyme activity have been associated with adiposity and metabolic disease. While this has been studied in adults, few studies have included children. The objective of this study was to evaluate these markers in children and identify relationships with markers of metabolic health. It was hypothesized that these lipid markers would be correlated to adiposity and metabolic disease. Methods: This study was a cross-sectional analysis of fourth- and fifth-grade children (n = 86, aged 9–12) participating in a comprehensive nutrition program. Any student enrolled in the program was eligible for inclusion in this study. Fasting plasma was collected and analyzed for total fatty acids, glucose, insulin, and full lipid panels. Insulin resistance was estimated using calculated homeostatic model assessment for insulin resistance (HOMA-IR) values. Results: There were no differences in lipid markers, glucose, insulin, or HOMA-IR among children classified as normal weight, overweight, or obese. SCD-16, D5D, and ELOVL6 activity was significantly correlated to HOMA-IR values (r = 0.39, p = 0.001; r = −0.33, p = 0.006; r = −0.37, p = 0.005, respectively). In regression analysis, body mass index for age percentile, D6D activity, ELOVL6 activity, and systolic blood pressure were the most significant predictors of HOMA-IR values (adjusted r2 = 0.39, p ≤ 0.001). Conclusions: There was no relationship between these lipid markers and adiposity in this population; however, there were correlations with HOMA-IR. Regardless of adiposity, there may be underlying changes in fatty acid and lipid metabolism associated with the development of metabolic diseases.

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KW - insulin resistance

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