Association of schistosomiasis and HIV infection in Tanzania

Jennifer A. Downs, Govert J. Van Dam, John M. Changalucha, Paul L A M Corstjens, Robert N. Peck, Claudia J. De Dood, Heejung Bang, Aura Andreasen, Samuel E. Kalluvya, Lisette Van Lieshout, Warren D. Johnson, Daniel W. Fitzgerald

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Animal and human studies suggest that Schistosoma mansoni infection may increase risk of human immunodeficiency virus (HIV) acquisition. Therefore, we tested 345 reproductive age women in rural Tanzanian villages near Lake Victoria, where S. mansoni is hyperendemic, for sexually transmitted infections (STIs) and schistosomiasis by circulating anodic antigen (CAA) serum assay. Over one-half (54%) had an active schistosome infection; 6% were HIV-seropositive. By univariate analysis, only schistosome infection predicted HIV infection (odds ratio [OR] = 3.9, 95% confidence interval = [1.3-12.0], P = 0.015) and remained significant using multivariate analysis to control for age, STIs, and distance from the lake (OR = 6.2 [1.7-22.9], P = 0.006). HIV prevalence was higher among women with more intense schistosome infections (P = 0.005), and the median schistosome intensity was higher in HIV-infected than -uninfected women (400 versus 15 pg CAA/mL, P = 0.01). This finding suggests that S. mansoni infection may be a modifiable HIV risk factor that places millions of people worldwide at increased risk of HIV acquisition.

Original languageEnglish (US)
Pages (from-to)868-873
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume87
Issue number5
DOIs
StatePublished - Nov 2012

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Tanzania
Schistosomiasis
Virus Diseases
HIV
Schistosomiasis mansoni
Lakes
Sexually Transmitted Diseases
Infection
Odds Ratio
Antigens
Schistosoma mansoni
Victoria
Multivariate Analysis
Confidence Intervals
Serum

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology

Cite this

Downs, J. A., Van Dam, G. J., Changalucha, J. M., Corstjens, P. L. A. M., Peck, R. N., De Dood, C. J., ... Fitzgerald, D. W. (2012). Association of schistosomiasis and HIV infection in Tanzania. American Journal of Tropical Medicine and Hygiene, 87(5), 868-873. https://doi.org/10.4269/ajtmh.2012.12-0395

Association of schistosomiasis and HIV infection in Tanzania. / Downs, Jennifer A.; Van Dam, Govert J.; Changalucha, John M.; Corstjens, Paul L A M; Peck, Robert N.; De Dood, Claudia J.; Bang, Heejung; Andreasen, Aura; Kalluvya, Samuel E.; Van Lieshout, Lisette; Johnson, Warren D.; Fitzgerald, Daniel W.

In: American Journal of Tropical Medicine and Hygiene, Vol. 87, No. 5, 11.2012, p. 868-873.

Research output: Contribution to journalArticle

Downs, JA, Van Dam, GJ, Changalucha, JM, Corstjens, PLAM, Peck, RN, De Dood, CJ, Bang, H, Andreasen, A, Kalluvya, SE, Van Lieshout, L, Johnson, WD & Fitzgerald, DW 2012, 'Association of schistosomiasis and HIV infection in Tanzania', American Journal of Tropical Medicine and Hygiene, vol. 87, no. 5, pp. 868-873. https://doi.org/10.4269/ajtmh.2012.12-0395
Downs JA, Van Dam GJ, Changalucha JM, Corstjens PLAM, Peck RN, De Dood CJ et al. Association of schistosomiasis and HIV infection in Tanzania. American Journal of Tropical Medicine and Hygiene. 2012 Nov;87(5):868-873. https://doi.org/10.4269/ajtmh.2012.12-0395
Downs, Jennifer A. ; Van Dam, Govert J. ; Changalucha, John M. ; Corstjens, Paul L A M ; Peck, Robert N. ; De Dood, Claudia J. ; Bang, Heejung ; Andreasen, Aura ; Kalluvya, Samuel E. ; Van Lieshout, Lisette ; Johnson, Warren D. ; Fitzgerald, Daniel W. / Association of schistosomiasis and HIV infection in Tanzania. In: American Journal of Tropical Medicine and Hygiene. 2012 ; Vol. 87, No. 5. pp. 868-873.
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