Association of plasma haptoglobin concentration and other biomarkers with bovine respiratory disease status in pre-weaned dairy calves

Sonia J. Moisá, Sharif S Aly, Terry W Lehenbauer, William J. Love, Paul V. Rossitto, Alison L. Van Eenennaam, Sophia C. Trombetta, Eduarda M. Bortoluzzi, Lindsey E. Hulbert

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We conducted a nested, case-control study of pre-weaned dairy calves (n = 477; 4 California dairy farms) to assess the association between bovine respiratory disease (BRD) and hematologic biomarkers, including plasma haptoglobin (Hp) and plasma bactericide (PB). At each location, heifer or bull dairy calves were observed 2–4 times per week until confirmed as BRD-positive using parallel interpretation of thoracic ultrasound examination and auscultation. In addition, control calves were enrolled after being confirmed as BRD-negative using ultrasound and auscultation. Complete blood counts (CBC), PB, and Hp concentrations were measured. Hp values were higher in calves with confirmed BRD than in controls (p < 0.01). The area under the curve (AUC) for the various biomarkers was obtained from the corresponding receiver operating characteristic curves. The AUC for Hp was 0.68, a value greater than those for PB or the remaining CBC parameters, indicating that Hp may be the most useful biomarker of BRD in pre-weaned dairy calves. The cutoff value for Hp was 0.195 g/L.

Original languageEnglish (US)
Pages (from-to)40-46
Number of pages7
JournalJournal of Veterinary Diagnostic Investigation
Volume31
Issue number1
DOIs
StatePublished - Jan 1 2019

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Cattle Diseases
bovine respiratory disease
Haptoglobins
dairy calves
haptoglobins
biomarkers
Biomarkers
Auscultation
Blood Cell Count
antibiotics
Area Under Curve
calves
blood
chest
case-control studies
ROC Curve
dairy farming
Farms
Case-Control Studies
heifers

Keywords

  • Bovine respiratory disease
  • calves
  • haptoglobin
  • plasma bactericide

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Association of plasma haptoglobin concentration and other biomarkers with bovine respiratory disease status in pre-weaned dairy calves. / Moisá, Sonia J.; Aly, Sharif S; Lehenbauer, Terry W; Love, William J.; Rossitto, Paul V.; Van Eenennaam, Alison L.; Trombetta, Sophia C.; Bortoluzzi, Eduarda M.; Hulbert, Lindsey E.

In: Journal of Veterinary Diagnostic Investigation, Vol. 31, No. 1, 01.01.2019, p. 40-46.

Research output: Contribution to journalArticle

Moisá, Sonia J. ; Aly, Sharif S ; Lehenbauer, Terry W ; Love, William J. ; Rossitto, Paul V. ; Van Eenennaam, Alison L. ; Trombetta, Sophia C. ; Bortoluzzi, Eduarda M. ; Hulbert, Lindsey E. / Association of plasma haptoglobin concentration and other biomarkers with bovine respiratory disease status in pre-weaned dairy calves. In: Journal of Veterinary Diagnostic Investigation. 2019 ; Vol. 31, No. 1. pp. 40-46.
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