Association of Physical Function with Clinical and Subclinical Brain Disease: The Framingham Offspring Study

Erica C. Camargo, Galit Weinstein, Alexa S. Beiser, Zaldy S. Tan, Charles DeCarli, Margaret Kelly-Hayes, Carlos Kase, Joanne M. Murabito, Sudha Seshadri

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Handgrip strength and gait speed are simple measures of physical capability and have been associated with current and future health outcomes. However, studies on their associations with brain structure and function in middle-aged adults are lacking. Objective: To assess the relationship of fast-paced walking speed and handgrip strength with risk of dementia, Alzheimer's disease (AD), and stroke, as well as the cross-sectional associations with cognitive and brain magnetic resonance imaging (MRI) measures in a middle-aged community sample. Methods: Framingham Offspring (n=2,176; mean age 62, 54 female) had physical function, brain MRI, and cognitive evaluations between 1999 and 2005 and were followed-up for incident dementia AD and stroke until 11 years later. We related walking speed and handgrip strength to incident dementia, AD, and stroke using Cox models, and to brain and cognitive measures using multivariable linear and logistic regression. Models were adjusted for age, sex, education, and vascular risk factors. Results: Slow walking and weak handgrip were associated with more than 2.5-fold increase in risk of AD. Weaker handgrip was associated with an increased risk of incident stroke (HR 1.74, 95 CI: 1.122.70/SDU, p=0.01) in persons ≥65 years. Both measures were associated with lower total brain volume and poorer performance on tests of visual memory, language, executive function, and visuoperceptual function. Slower gait was also related to poorer verbal memory, and weaker handgrip to poorer abstraction. Conclusion: Tests of walking speed and handgrip strength may serve as clinical markers of brain structure and function and may improve dementia risk prediction.

Original languageEnglish (US)
Pages (from-to)1597-1608
Number of pages12
JournalJournal of Alzheimer's Disease
Volume53
Issue number4
DOIs
StatePublished - 2016

Fingerprint

Brain Diseases
Dementia
Alzheimer Disease
Brain
Stroke
Magnetic Resonance Imaging
Sex Education
Executive Function
Gait
Proportional Hazards Models
Walking
Linear Models
Language
Biomarkers
Logistic Models
Walking Speed
Health

Keywords

  • Alzheimer's disease
  • Brain imaging
  • Cognitive function
  • Dementia
  • Gait
  • Hand strength
  • Observational study
  • Stroke

ASJC Scopus subject areas

  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Association of Physical Function with Clinical and Subclinical Brain Disease : The Framingham Offspring Study. / Camargo, Erica C.; Weinstein, Galit; Beiser, Alexa S.; Tan, Zaldy S.; DeCarli, Charles; Kelly-Hayes, Margaret; Kase, Carlos; Murabito, Joanne M.; Seshadri, Sudha.

In: Journal of Alzheimer's Disease, Vol. 53, No. 4, 2016, p. 1597-1608.

Research output: Contribution to journalArticle

Camargo, EC, Weinstein, G, Beiser, AS, Tan, ZS, DeCarli, C, Kelly-Hayes, M, Kase, C, Murabito, JM & Seshadri, S 2016, 'Association of Physical Function with Clinical and Subclinical Brain Disease: The Framingham Offspring Study', Journal of Alzheimer's Disease, vol. 53, no. 4, pp. 1597-1608. https://doi.org/10.3233/JAD-160229
Camargo, Erica C. ; Weinstein, Galit ; Beiser, Alexa S. ; Tan, Zaldy S. ; DeCarli, Charles ; Kelly-Hayes, Margaret ; Kase, Carlos ; Murabito, Joanne M. ; Seshadri, Sudha. / Association of Physical Function with Clinical and Subclinical Brain Disease : The Framingham Offspring Study. In: Journal of Alzheimer's Disease. 2016 ; Vol. 53, No. 4. pp. 1597-1608.
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AU - Tan, Zaldy S.

AU - DeCarli, Charles

AU - Kelly-Hayes, Margaret

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AU - Seshadri, Sudha

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N2 - Background: Handgrip strength and gait speed are simple measures of physical capability and have been associated with current and future health outcomes. However, studies on their associations with brain structure and function in middle-aged adults are lacking. Objective: To assess the relationship of fast-paced walking speed and handgrip strength with risk of dementia, Alzheimer's disease (AD), and stroke, as well as the cross-sectional associations with cognitive and brain magnetic resonance imaging (MRI) measures in a middle-aged community sample. Methods: Framingham Offspring (n=2,176; mean age 62, 54 female) had physical function, brain MRI, and cognitive evaluations between 1999 and 2005 and were followed-up for incident dementia AD and stroke until 11 years later. We related walking speed and handgrip strength to incident dementia, AD, and stroke using Cox models, and to brain and cognitive measures using multivariable linear and logistic regression. Models were adjusted for age, sex, education, and vascular risk factors. Results: Slow walking and weak handgrip were associated with more than 2.5-fold increase in risk of AD. Weaker handgrip was associated with an increased risk of incident stroke (HR 1.74, 95 CI: 1.122.70/SDU, p=0.01) in persons ≥65 years. Both measures were associated with lower total brain volume and poorer performance on tests of visual memory, language, executive function, and visuoperceptual function. Slower gait was also related to poorer verbal memory, and weaker handgrip to poorer abstraction. Conclusion: Tests of walking speed and handgrip strength may serve as clinical markers of brain structure and function and may improve dementia risk prediction.

AB - Background: Handgrip strength and gait speed are simple measures of physical capability and have been associated with current and future health outcomes. However, studies on their associations with brain structure and function in middle-aged adults are lacking. Objective: To assess the relationship of fast-paced walking speed and handgrip strength with risk of dementia, Alzheimer's disease (AD), and stroke, as well as the cross-sectional associations with cognitive and brain magnetic resonance imaging (MRI) measures in a middle-aged community sample. Methods: Framingham Offspring (n=2,176; mean age 62, 54 female) had physical function, brain MRI, and cognitive evaluations between 1999 and 2005 and were followed-up for incident dementia AD and stroke until 11 years later. We related walking speed and handgrip strength to incident dementia, AD, and stroke using Cox models, and to brain and cognitive measures using multivariable linear and logistic regression. Models were adjusted for age, sex, education, and vascular risk factors. Results: Slow walking and weak handgrip were associated with more than 2.5-fold increase in risk of AD. Weaker handgrip was associated with an increased risk of incident stroke (HR 1.74, 95 CI: 1.122.70/SDU, p=0.01) in persons ≥65 years. Both measures were associated with lower total brain volume and poorer performance on tests of visual memory, language, executive function, and visuoperceptual function. Slower gait was also related to poorer verbal memory, and weaker handgrip to poorer abstraction. Conclusion: Tests of walking speed and handgrip strength may serve as clinical markers of brain structure and function and may improve dementia risk prediction.

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KW - Gait

KW - Hand strength

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