Association of incident symptomatic hip osteoarthritis with differences in hip shape by active shape modeling: The johnston county osteoarthritis project

Amanda E. Nelson, Felix Liu, John A. Lynch, Jordan B. Renner, Todd A. Schwartz, Nancy E Lane, Joanne M. Jordan

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Abstract

Objective To investigate hip shape by active shape modeling (ASM) as a potential predictor of incident radiographic hip osteoarthritis (RHOA) and symptomatic hip osteoarthritis (SRHOA). Methods All hips developing RHOA from baseline (Kellgren/Lawrence [K/L] grade 0/1) to mean 6-year followup (K/L grade ≥2, 190 hips) and 1:1 control hips (K/L grade 0/1 at both times, 192 hips) were included. Proximal femur shape was defined on baseline anteroposterior pelvis radiographs and submitted to ASM, producing a mean shape and continuous variables representing independent modes of shape variation. Mode scores (n = 14, explaining 95% of shape variance) were simultaneously included in logistic regression models with incident RHOA and SRHOA as dependent variables, adjusted for intraperson correlations, sex, race, body mass index (BMI), baseline K/L grade, and/or symptoms. Results We evaluated 382 hips from 342 individuals: 61% women and 83% white, with mean age 62 years and mean BMI 29 kg/m2. Several modes differed by sex and race, but no modes were associated with incident RHOA overall. Among men only, modes 1 and 2 were significantly associated (for a 1-SD decrease in mode 1 score: odds ratio [OR] 1.7 [95% confidence interval (95% CI) 1.1-2.5] and for a 1-SD increase in mode 2 score: OR 1.5 [95% CI 1.0-2.2]) with incident RHOA. A 1-SD decrease in mode 2 or 3 score increased the odds of SRHOA by 50%. Conclusion This study confirms other reports that variations in proximal femur shape have a modest association with incident hip OA. The observation of proximal femur shape associations with hip symptoms requires further investigation.

Original languageEnglish (US)
Pages (from-to)74-81
Number of pages8
JournalArthritis Care and Research
Volume66
Issue number1
DOIs
StatePublished - Jan 2014

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Hip Osteoarthritis
Osteoarthritis
Hip
Femur
Body Mass Index
Logistic Models
Odds Ratio
Confidence Intervals
Pelvis
Observation

ASJC Scopus subject areas

  • Rheumatology

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Association of incident symptomatic hip osteoarthritis with differences in hip shape by active shape modeling : The johnston county osteoarthritis project. / Nelson, Amanda E.; Liu, Felix; Lynch, John A.; Renner, Jordan B.; Schwartz, Todd A.; Lane, Nancy E; Jordan, Joanne M.

In: Arthritis Care and Research, Vol. 66, No. 1, 01.2014, p. 74-81.

Research output: Contribution to journalArticle

Nelson, Amanda E. ; Liu, Felix ; Lynch, John A. ; Renner, Jordan B. ; Schwartz, Todd A. ; Lane, Nancy E ; Jordan, Joanne M. / Association of incident symptomatic hip osteoarthritis with differences in hip shape by active shape modeling : The johnston county osteoarthritis project. In: Arthritis Care and Research. 2014 ; Vol. 66, No. 1. pp. 74-81.
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abstract = "Objective To investigate hip shape by active shape modeling (ASM) as a potential predictor of incident radiographic hip osteoarthritis (RHOA) and symptomatic hip osteoarthritis (SRHOA). Methods All hips developing RHOA from baseline (Kellgren/Lawrence [K/L] grade 0/1) to mean 6-year followup (K/L grade ≥2, 190 hips) and 1:1 control hips (K/L grade 0/1 at both times, 192 hips) were included. Proximal femur shape was defined on baseline anteroposterior pelvis radiographs and submitted to ASM, producing a mean shape and continuous variables representing independent modes of shape variation. Mode scores (n = 14, explaining 95{\%} of shape variance) were simultaneously included in logistic regression models with incident RHOA and SRHOA as dependent variables, adjusted for intraperson correlations, sex, race, body mass index (BMI), baseline K/L grade, and/or symptoms. Results We evaluated 382 hips from 342 individuals: 61{\%} women and 83{\%} white, with mean age 62 years and mean BMI 29 kg/m2. Several modes differed by sex and race, but no modes were associated with incident RHOA overall. Among men only, modes 1 and 2 were significantly associated (for a 1-SD decrease in mode 1 score: odds ratio [OR] 1.7 [95{\%} confidence interval (95{\%} CI) 1.1-2.5] and for a 1-SD increase in mode 2 score: OR 1.5 [95{\%} CI 1.0-2.2]) with incident RHOA. A 1-SD decrease in mode 2 or 3 score increased the odds of SRHOA by 50{\%}. Conclusion This study confirms other reports that variations in proximal femur shape have a modest association with incident hip OA. The observation of proximal femur shape associations with hip symptoms requires further investigation.",
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