Association of Ideal Cardiovascular Health With Vascular Brain Injury and Incident Dementia

Matthew P. Pase, Alexa Beiser, Danielle Enserro, Vanessa Xanthakis, Hugo Aparicio, Claudia L. Satizabal, Jayandra J. Himali, Carlos S. Kase, Ramachandran S. Vasan, Charles DeCarli, Sudha Seshadri

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background and Purpose - The American Heart Association developed the ideal cardiovascular health (CVH) index as a simple tool to promote CVH; yet, its association with brain atrophy and dementia remains unexamined. Methods - Our aim was to investigate the prospective association of ideal CVH with vascular brain injury, including the 10-year risks of incident stroke and dementia, as well as cognitive decline and brain atrophy on magnetic resonance imaging, measured for ≈7 years. We studied 2750 stroke- and dementia-free Framingham Heart Study Offspring cohort participants (mean age, 62±9 years; 45% men). Ideal CVH was quantified on a 7-point scale with 1 point awarded for each of the following: nonsmoking status, ideal body mass index, regular physical activity, healthy diet, as well as optimum blood pressure, cholesterol, and fasting blood glucose. Both recent (baseline) and remote (6.9 years earlier) ideal CVH scores were examined. Results - Recent ideal CVH was associated with stroke (hazard ratio, 0.80; 95% confidence interval, 0.67-0.95), vascular dementia (hazard ratio, 0.49; 95% confidence interval, 0.30-0.81), frontal brain atrophy (P=0.003), and cognitive decline on tasks measuring visual memory and reasoning (P<0.05). In addition to predicting stroke, vascular dementia, whole-brain atrophy, and cognitive decline, remote ideal CVH was associated with the incidence of all-cause dementia (hazard ratio, 0.80; 95% confidence interval, 0.67-0.97) and Alzheimer disease (hazard ratio, 0.79; 95% confidence interval, 0.64-0.98). Conclusions - Adherence to the American Heart Association's ideal CVH factors and behaviors, particularly in midlife, may protect against cerebrovascular disease and dementia.

Original languageEnglish (US)
Pages (from-to)1201-1206
Number of pages6
JournalStroke
Volume47
Issue number5
DOIs
StatePublished - May 1 2016

Fingerprint

Cerebrovascular Trauma
Dementia
Health
Atrophy
Stroke
Confidence Intervals
Vascular Dementia
Brain
American Heart Association
Cerebrovascular Disorders
Ideal Body Weight
Blood Glucose
Fasting
Alzheimer Disease
Body Mass Index
Cohort Studies
Cholesterol
Magnetic Resonance Imaging
Exercise

Keywords

  • American Heart Association
  • brain
  • cerebrovascular disorders
  • epidemiology
  • risk factors

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Pase, M. P., Beiser, A., Enserro, D., Xanthakis, V., Aparicio, H., Satizabal, C. L., ... Seshadri, S. (2016). Association of Ideal Cardiovascular Health With Vascular Brain Injury and Incident Dementia. Stroke, 47(5), 1201-1206. https://doi.org/10.1161/STROKEAHA.115.012608

Association of Ideal Cardiovascular Health With Vascular Brain Injury and Incident Dementia. / Pase, Matthew P.; Beiser, Alexa; Enserro, Danielle; Xanthakis, Vanessa; Aparicio, Hugo; Satizabal, Claudia L.; Himali, Jayandra J.; Kase, Carlos S.; Vasan, Ramachandran S.; DeCarli, Charles; Seshadri, Sudha.

In: Stroke, Vol. 47, No. 5, 01.05.2016, p. 1201-1206.

Research output: Contribution to journalArticle

Pase, MP, Beiser, A, Enserro, D, Xanthakis, V, Aparicio, H, Satizabal, CL, Himali, JJ, Kase, CS, Vasan, RS, DeCarli, C & Seshadri, S 2016, 'Association of Ideal Cardiovascular Health With Vascular Brain Injury and Incident Dementia', Stroke, vol. 47, no. 5, pp. 1201-1206. https://doi.org/10.1161/STROKEAHA.115.012608
Pase MP, Beiser A, Enserro D, Xanthakis V, Aparicio H, Satizabal CL et al. Association of Ideal Cardiovascular Health With Vascular Brain Injury and Incident Dementia. Stroke. 2016 May 1;47(5):1201-1206. https://doi.org/10.1161/STROKEAHA.115.012608
Pase, Matthew P. ; Beiser, Alexa ; Enserro, Danielle ; Xanthakis, Vanessa ; Aparicio, Hugo ; Satizabal, Claudia L. ; Himali, Jayandra J. ; Kase, Carlos S. ; Vasan, Ramachandran S. ; DeCarli, Charles ; Seshadri, Sudha. / Association of Ideal Cardiovascular Health With Vascular Brain Injury and Incident Dementia. In: Stroke. 2016 ; Vol. 47, No. 5. pp. 1201-1206.
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abstract = "Background and Purpose - The American Heart Association developed the ideal cardiovascular health (CVH) index as a simple tool to promote CVH; yet, its association with brain atrophy and dementia remains unexamined. Methods - Our aim was to investigate the prospective association of ideal CVH with vascular brain injury, including the 10-year risks of incident stroke and dementia, as well as cognitive decline and brain atrophy on magnetic resonance imaging, measured for ≈7 years. We studied 2750 stroke- and dementia-free Framingham Heart Study Offspring cohort participants (mean age, 62±9 years; 45{\%} men). Ideal CVH was quantified on a 7-point scale with 1 point awarded for each of the following: nonsmoking status, ideal body mass index, regular physical activity, healthy diet, as well as optimum blood pressure, cholesterol, and fasting blood glucose. Both recent (baseline) and remote (6.9 years earlier) ideal CVH scores were examined. Results - Recent ideal CVH was associated with stroke (hazard ratio, 0.80; 95{\%} confidence interval, 0.67-0.95), vascular dementia (hazard ratio, 0.49; 95{\%} confidence interval, 0.30-0.81), frontal brain atrophy (P=0.003), and cognitive decline on tasks measuring visual memory and reasoning (P<0.05). In addition to predicting stroke, vascular dementia, whole-brain atrophy, and cognitive decline, remote ideal CVH was associated with the incidence of all-cause dementia (hazard ratio, 0.80; 95{\%} confidence interval, 0.67-0.97) and Alzheimer disease (hazard ratio, 0.79; 95{\%} confidence interval, 0.64-0.98). Conclusions - Adherence to the American Heart Association's ideal CVH factors and behaviors, particularly in midlife, may protect against cerebrovascular disease and dementia.",
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