Association of Herpes Simplex Virus Testing with Hospital Length of Stay for Infants ≤60 Days of Age Undergoing Evaluation for Meningitis

Pediatric Emergency Medicine Clinical Research Network (PEM CRC) Herpes Simplex Virus (HSV) Study Group

Research output: Contribution to journalArticle

Abstract

Although neonatal herpes simplex virus (HSV) causes significant morbidity, utilization of the cerebrospinal fluid (CSF) HSV polymerase chain reaction (PCR) test remains variable. Our objective was to examine the association of CSF HSV PCR testing with length of stay (LOS) in a 20-center retrospective cohort of hospitalized infants aged ≤60 days undergoing evaluation for meningitis after adjustment for patient-level factors and clustering by center. Of 20,496 eligible infants, 7,399 (36.1%) had a CSF HSV PCR test performed, and 46 (0.6% of those tested) had a positive test. Infants who had a CSF HSV PCR test performed had a 23% longer hospital LOS (incident rate ratio 1.23; 95% CI: 1.14-1.33). Targeted CSF HSV PCR testing may mitigate the impact on LOS for low-risk infants.

Original languageEnglish (US)
Pages (from-to)492-495
Number of pages4
JournalJournal of Hospital Medicine
Volume14
Issue number8
DOIs
StatePublished - Aug 1 2019

Fingerprint

Simplexvirus
Meningitis
Length of Stay
Cerebrospinal Fluid
Polymerase Chain Reaction
Cluster Analysis
Morbidity

ASJC Scopus subject areas

  • Leadership and Management
  • Fundamentals and skills
  • Health Policy
  • Care Planning
  • Assessment and Diagnosis

Cite this

Association of Herpes Simplex Virus Testing with Hospital Length of Stay for Infants ≤60 Days of Age Undergoing Evaluation for Meningitis. / Pediatric Emergency Medicine Clinical Research Network (PEM CRC) Herpes Simplex Virus (HSV) Study Group.

In: Journal of Hospital Medicine, Vol. 14, No. 8, 01.08.2019, p. 492-495.

Research output: Contribution to journalArticle

Pediatric Emergency Medicine Clinical Research Network (PEM CRC) Herpes Simplex Virus (HSV) Study Group 2019, 'Association of Herpes Simplex Virus Testing with Hospital Length of Stay for Infants ≤60 Days of Age Undergoing Evaluation for Meningitis', Journal of Hospital Medicine, vol. 14, no. 8, pp. 492-495. https://doi.org/10.12788/jhm.3202
Pediatric Emergency Medicine Clinical Research Network (PEM CRC) Herpes Simplex Virus (HSV) Study Group. Association of Herpes Simplex Virus Testing with Hospital Length of Stay for Infants ≤60 Days of Age Undergoing Evaluation for Meningitis. Journal of Hospital Medicine. 2019 Aug 1;14(8):492-495. https://doi.org/10.12788/jhm.3202
Pediatric Emergency Medicine Clinical Research Network (PEM CRC) Herpes Simplex Virus (HSV) Study Group. / Association of Herpes Simplex Virus Testing with Hospital Length of Stay for Infants ≤60 Days of Age Undergoing Evaluation for Meningitis. In: Journal of Hospital Medicine. 2019 ; Vol. 14, No. 8. pp. 492-495.
@article{d3adde90e3c6465fb1088bace033b9b7,
title = "Association of Herpes Simplex Virus Testing with Hospital Length of Stay for Infants ≤60 Days of Age Undergoing Evaluation for Meningitis",
abstract = "Although neonatal herpes simplex virus (HSV) causes significant morbidity, utilization of the cerebrospinal fluid (CSF) HSV polymerase chain reaction (PCR) test remains variable. Our objective was to examine the association of CSF HSV PCR testing with length of stay (LOS) in a 20-center retrospective cohort of hospitalized infants aged ≤60 days undergoing evaluation for meningitis after adjustment for patient-level factors and clustering by center. Of 20,496 eligible infants, 7,399 (36.1{\%}) had a CSF HSV PCR test performed, and 46 (0.6{\%} of those tested) had a positive test. Infants who had a CSF HSV PCR test performed had a 23{\%} longer hospital LOS (incident rate ratio 1.23; 95{\%} CI: 1.14-1.33). Targeted CSF HSV PCR testing may mitigate the impact on LOS for low-risk infants.",
author = "{Pediatric Emergency Medicine Clinical Research Network (PEM CRC) Herpes Simplex Virus (HSV) Study Group} and Aronson, {Paul L.} and Cruz, {Andrea T.} and Freedman, {Stephen B.} and Fran Balamuth and Grether-Jones, {Kendra L} and Lyons, {Todd W.} and Fleming, {Alesia H.} and Jeffrey Louie and Mistry, {Rakesh D.} and Garro, {Aris C.} and Shah, {Samir S.} and Nigrovic, {Lise E.}",
year = "2019",
month = "8",
day = "1",
doi = "10.12788/jhm.3202",
language = "English (US)",
volume = "14",
pages = "492--495",
journal = "Journal of hospital medicine (Online)",
issn = "1553-5606",
publisher = "John Wiley and Sons Inc.",
number = "8",

}

TY - JOUR

T1 - Association of Herpes Simplex Virus Testing with Hospital Length of Stay for Infants ≤60 Days of Age Undergoing Evaluation for Meningitis

AU - Pediatric Emergency Medicine Clinical Research Network (PEM CRC) Herpes Simplex Virus (HSV) Study Group

AU - Aronson, Paul L.

AU - Cruz, Andrea T.

AU - Freedman, Stephen B.

AU - Balamuth, Fran

AU - Grether-Jones, Kendra L

AU - Lyons, Todd W.

AU - Fleming, Alesia H.

AU - Louie, Jeffrey

AU - Mistry, Rakesh D.

AU - Garro, Aris C.

AU - Shah, Samir S.

AU - Nigrovic, Lise E.

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Although neonatal herpes simplex virus (HSV) causes significant morbidity, utilization of the cerebrospinal fluid (CSF) HSV polymerase chain reaction (PCR) test remains variable. Our objective was to examine the association of CSF HSV PCR testing with length of stay (LOS) in a 20-center retrospective cohort of hospitalized infants aged ≤60 days undergoing evaluation for meningitis after adjustment for patient-level factors and clustering by center. Of 20,496 eligible infants, 7,399 (36.1%) had a CSF HSV PCR test performed, and 46 (0.6% of those tested) had a positive test. Infants who had a CSF HSV PCR test performed had a 23% longer hospital LOS (incident rate ratio 1.23; 95% CI: 1.14-1.33). Targeted CSF HSV PCR testing may mitigate the impact on LOS for low-risk infants.

AB - Although neonatal herpes simplex virus (HSV) causes significant morbidity, utilization of the cerebrospinal fluid (CSF) HSV polymerase chain reaction (PCR) test remains variable. Our objective was to examine the association of CSF HSV PCR testing with length of stay (LOS) in a 20-center retrospective cohort of hospitalized infants aged ≤60 days undergoing evaluation for meningitis after adjustment for patient-level factors and clustering by center. Of 20,496 eligible infants, 7,399 (36.1%) had a CSF HSV PCR test performed, and 46 (0.6% of those tested) had a positive test. Infants who had a CSF HSV PCR test performed had a 23% longer hospital LOS (incident rate ratio 1.23; 95% CI: 1.14-1.33). Targeted CSF HSV PCR testing may mitigate the impact on LOS for low-risk infants.

UR - http://www.scopus.com/inward/record.url?scp=85071069292&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071069292&partnerID=8YFLogxK

U2 - 10.12788/jhm.3202

DO - 10.12788/jhm.3202

M3 - Article

VL - 14

SP - 492

EP - 495

JO - Journal of hospital medicine (Online)

JF - Journal of hospital medicine (Online)

SN - 1553-5606

IS - 8

ER -