Association of diet and mammographic breast density in the Minnesota breast cancer family cohort

Celine M. Vachon, Lawrence H. Kushi, James R. Cerhan, Christopher C. Kuni, Thomas A. Sellers

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Mammographic breast density is a significant risk factor for breast cancer. The present report analyzes the association of breast density and dietary factors in 1508 women in a historical cohort study of breast cancer families in Minnesota. Diet was assessed by a semiquantitative food frequency questionnaire. Percent breast density was estimated visually by a radiologist experienced in mammography. The association of percent breast density with quartiles of energy-adjusted dietary intakes was examined in analysis of covariance models adjusting for potential confounding effects of age, body mass index, and other covariates as well as correcting for familial correlation. Analyses were performed on all women combined and were also stratified by menopausal status. Among premenopausal women, percent breast density was positively associated with intakes of polyunsaturated fat, polyunsaturated:saturated fat ratio, and vitamins C and E and was inversely associated with saturated fat and total dairy intake. Among postmenopausal women, vitamin B12 was linearly associated with increased breast density. The positive associations for vitamin C and B12 were attributable to supplement intake only. There was a suggestive positive trend between breast density and daily alcohol consumption in both premenopausal and postmenopausal women. After adjustment for other sources of alcohol, only wine intake among postmenopausal women was significant such that white wine showed a positive association and red wine an inverse association with percent breast density. There was no association with other examined dietary factors. The cross-sectional differences in breast density across levels of dietary factors were small in magnitude but may have implications for breast cancer risk.

Original languageEnglish (US)
Pages (from-to)151-160
Number of pages10
JournalCancer Epidemiology Biomarkers and Prevention
Volume9
Issue number2
StatePublished - Feb 2000
Externally publishedYes

Fingerprint

Breast Neoplasms
Diet
Wine
Fats
Vitamin B 12
Ascorbic Acid
Breast Density
Mammography
Vitamin E
Alcohol Drinking
Body Mass Index
Cohort Studies
Alcohols
Food

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Vachon, C. M., Kushi, L. H., Cerhan, J. R., Kuni, C. C., & Sellers, T. A. (2000). Association of diet and mammographic breast density in the Minnesota breast cancer family cohort. Cancer Epidemiology Biomarkers and Prevention, 9(2), 151-160.

Association of diet and mammographic breast density in the Minnesota breast cancer family cohort. / Vachon, Celine M.; Kushi, Lawrence H.; Cerhan, James R.; Kuni, Christopher C.; Sellers, Thomas A.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 9, No. 2, 02.2000, p. 151-160.

Research output: Contribution to journalArticle

Vachon, CM, Kushi, LH, Cerhan, JR, Kuni, CC & Sellers, TA 2000, 'Association of diet and mammographic breast density in the Minnesota breast cancer family cohort', Cancer Epidemiology Biomarkers and Prevention, vol. 9, no. 2, pp. 151-160.
Vachon, Celine M. ; Kushi, Lawrence H. ; Cerhan, James R. ; Kuni, Christopher C. ; Sellers, Thomas A. / Association of diet and mammographic breast density in the Minnesota breast cancer family cohort. In: Cancer Epidemiology Biomarkers and Prevention. 2000 ; Vol. 9, No. 2. pp. 151-160.
@article{73b4950b7fcb4114882f228901a6e8ec,
title = "Association of diet and mammographic breast density in the Minnesota breast cancer family cohort",
abstract = "Mammographic breast density is a significant risk factor for breast cancer. The present report analyzes the association of breast density and dietary factors in 1508 women in a historical cohort study of breast cancer families in Minnesota. Diet was assessed by a semiquantitative food frequency questionnaire. Percent breast density was estimated visually by a radiologist experienced in mammography. The association of percent breast density with quartiles of energy-adjusted dietary intakes was examined in analysis of covariance models adjusting for potential confounding effects of age, body mass index, and other covariates as well as correcting for familial correlation. Analyses were performed on all women combined and were also stratified by menopausal status. Among premenopausal women, percent breast density was positively associated with intakes of polyunsaturated fat, polyunsaturated:saturated fat ratio, and vitamins C and E and was inversely associated with saturated fat and total dairy intake. Among postmenopausal women, vitamin B12 was linearly associated with increased breast density. The positive associations for vitamin C and B12 were attributable to supplement intake only. There was a suggestive positive trend between breast density and daily alcohol consumption in both premenopausal and postmenopausal women. After adjustment for other sources of alcohol, only wine intake among postmenopausal women was significant such that white wine showed a positive association and red wine an inverse association with percent breast density. There was no association with other examined dietary factors. The cross-sectional differences in breast density across levels of dietary factors were small in magnitude but may have implications for breast cancer risk.",
author = "Vachon, {Celine M.} and Kushi, {Lawrence H.} and Cerhan, {James R.} and Kuni, {Christopher C.} and Sellers, {Thomas A.}",
year = "2000",
month = "2",
language = "English (US)",
volume = "9",
pages = "151--160",
journal = "Cancer Epidemiology Biomarkers and Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",
number = "2",

}

TY - JOUR

T1 - Association of diet and mammographic breast density in the Minnesota breast cancer family cohort

AU - Vachon, Celine M.

AU - Kushi, Lawrence H.

AU - Cerhan, James R.

AU - Kuni, Christopher C.

AU - Sellers, Thomas A.

PY - 2000/2

Y1 - 2000/2

N2 - Mammographic breast density is a significant risk factor for breast cancer. The present report analyzes the association of breast density and dietary factors in 1508 women in a historical cohort study of breast cancer families in Minnesota. Diet was assessed by a semiquantitative food frequency questionnaire. Percent breast density was estimated visually by a radiologist experienced in mammography. The association of percent breast density with quartiles of energy-adjusted dietary intakes was examined in analysis of covariance models adjusting for potential confounding effects of age, body mass index, and other covariates as well as correcting for familial correlation. Analyses were performed on all women combined and were also stratified by menopausal status. Among premenopausal women, percent breast density was positively associated with intakes of polyunsaturated fat, polyunsaturated:saturated fat ratio, and vitamins C and E and was inversely associated with saturated fat and total dairy intake. Among postmenopausal women, vitamin B12 was linearly associated with increased breast density. The positive associations for vitamin C and B12 were attributable to supplement intake only. There was a suggestive positive trend between breast density and daily alcohol consumption in both premenopausal and postmenopausal women. After adjustment for other sources of alcohol, only wine intake among postmenopausal women was significant such that white wine showed a positive association and red wine an inverse association with percent breast density. There was no association with other examined dietary factors. The cross-sectional differences in breast density across levels of dietary factors were small in magnitude but may have implications for breast cancer risk.

AB - Mammographic breast density is a significant risk factor for breast cancer. The present report analyzes the association of breast density and dietary factors in 1508 women in a historical cohort study of breast cancer families in Minnesota. Diet was assessed by a semiquantitative food frequency questionnaire. Percent breast density was estimated visually by a radiologist experienced in mammography. The association of percent breast density with quartiles of energy-adjusted dietary intakes was examined in analysis of covariance models adjusting for potential confounding effects of age, body mass index, and other covariates as well as correcting for familial correlation. Analyses were performed on all women combined and were also stratified by menopausal status. Among premenopausal women, percent breast density was positively associated with intakes of polyunsaturated fat, polyunsaturated:saturated fat ratio, and vitamins C and E and was inversely associated with saturated fat and total dairy intake. Among postmenopausal women, vitamin B12 was linearly associated with increased breast density. The positive associations for vitamin C and B12 were attributable to supplement intake only. There was a suggestive positive trend between breast density and daily alcohol consumption in both premenopausal and postmenopausal women. After adjustment for other sources of alcohol, only wine intake among postmenopausal women was significant such that white wine showed a positive association and red wine an inverse association with percent breast density. There was no association with other examined dietary factors. The cross-sectional differences in breast density across levels of dietary factors were small in magnitude but may have implications for breast cancer risk.

UR - http://www.scopus.com/inward/record.url?scp=0033996886&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033996886&partnerID=8YFLogxK

M3 - Article

VL - 9

SP - 151

EP - 160

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

IS - 2

ER -