Association of diabetes mellitus and biochemical knee cartilage composition assessed by T2 relaxation time measurements: Data from the osteoarthritis initiative

Nattagan Chanchek, Alexandra S. Gersing, Benedikt J. Schwaiger, Michael C. Nevitt, Jan Neumann, Gabby B. Joseph, Nancy E Lane, Julia Zarnowski, Felix C. Hofmann, Ursula Heilmeier, Charles E. Mcculloch, Thomas M. Link

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: To investigate the association of the presence and severity of diabetes mellitus (DM) with articular cartilage composition, using magnetic resonance imaging (MRI)-based T2 relaxation time measurements, and structural knee abnormalities. Materials and Methods: In the Osteoarthritis Initiative 208, participants with DM (age 63.0 ± 8.9 years; 111 females) and risk factors for osteoarthritis (OA) or mild radiographic tibiofemoral OA (Kellgren-Lawrence [KL] grade ≤2) were identified and group-matched with 208 controls without DM (age 63.3 ± 9.1 years; 111 females). Subjects with diabetes-related renal or ophthalmological complications or insulin treatment at baseline (n = 50) were defined as severe DM. 3T MR images of the right knee were assessed for articular cartilage T2, including texture and laminar analyses derived from the patella, medial, and lateral femur and tibia and for structural abnormalities using the modified whole-organ magnetic resonance imaging score (WORMS). Clustered linear regression analyses were used to assess associations of DM with MRI findings. Results: DM subjects had significantly higher cartilage T2 in the patella (mean difference 0.92 msec [95% confidence interval (CI) 0.79, 1.06]; P = 0.001) and medial femur (mean difference 0.36 msec [95% CI 0.27, 0.81]; P = 0.006) compared to controls. Averaged over all compartments, DM subjects showed significantly higher texture parameters (variance, P = 0.001; contrast, P = 0.002; entropy, P < 0.001). Subjects with severe DM additionally showed higher T2 in the medial tibial deep and superficial layers (P = 0.011 and P = 0.041) compared to controls. No significant differences in cartilage, meniscus, and overall WORMS were found between the groups (P > 0.05). Conclusion: In comparison to nondiabetic controls, cartilage in DM subjects showed higher and more heterogeneous cartilage T2 values, indicating increased articular cartilage degeneration. This affected even more compartments in subjects with severe DM.

Original languageEnglish (US)
JournalJournal of Magnetic Resonance Imaging
DOIs
StateAccepted/In press - 2017

Fingerprint

Osteoarthritis
Cartilage
Knee
Diabetes Mellitus
Articular Cartilage
Patella
Magnetic Resonance Imaging
Femur
Confidence Intervals
Entropy
Tibia
Linear Models
Research Design
Regression Analysis
Insulin
Kidney

Keywords

  • Cartilage imaging
  • Diabetes
  • Knee osteoarthritis
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Association of diabetes mellitus and biochemical knee cartilage composition assessed by T2 relaxation time measurements : Data from the osteoarthritis initiative. / Chanchek, Nattagan; Gersing, Alexandra S.; Schwaiger, Benedikt J.; Nevitt, Michael C.; Neumann, Jan; Joseph, Gabby B.; Lane, Nancy E; Zarnowski, Julia; Hofmann, Felix C.; Heilmeier, Ursula; Mcculloch, Charles E.; Link, Thomas M.

In: Journal of Magnetic Resonance Imaging, 2017.

Research output: Contribution to journalArticle

Chanchek, Nattagan ; Gersing, Alexandra S. ; Schwaiger, Benedikt J. ; Nevitt, Michael C. ; Neumann, Jan ; Joseph, Gabby B. ; Lane, Nancy E ; Zarnowski, Julia ; Hofmann, Felix C. ; Heilmeier, Ursula ; Mcculloch, Charles E. ; Link, Thomas M. / Association of diabetes mellitus and biochemical knee cartilage composition assessed by T2 relaxation time measurements : Data from the osteoarthritis initiative. In: Journal of Magnetic Resonance Imaging. 2017.
@article{c9e616a3f53a4c2a85e007e9ac20792a,
title = "Association of diabetes mellitus and biochemical knee cartilage composition assessed by T2 relaxation time measurements: Data from the osteoarthritis initiative",
abstract = "Purpose: To investigate the association of the presence and severity of diabetes mellitus (DM) with articular cartilage composition, using magnetic resonance imaging (MRI)-based T2 relaxation time measurements, and structural knee abnormalities. Materials and Methods: In the Osteoarthritis Initiative 208, participants with DM (age 63.0 ± 8.9 years; 111 females) and risk factors for osteoarthritis (OA) or mild radiographic tibiofemoral OA (Kellgren-Lawrence [KL] grade ≤2) were identified and group-matched with 208 controls without DM (age 63.3 ± 9.1 years; 111 females). Subjects with diabetes-related renal or ophthalmological complications or insulin treatment at baseline (n = 50) were defined as severe DM. 3T MR images of the right knee were assessed for articular cartilage T2, including texture and laminar analyses derived from the patella, medial, and lateral femur and tibia and for structural abnormalities using the modified whole-organ magnetic resonance imaging score (WORMS). Clustered linear regression analyses were used to assess associations of DM with MRI findings. Results: DM subjects had significantly higher cartilage T2 in the patella (mean difference 0.92 msec [95{\%} confidence interval (CI) 0.79, 1.06]; P = 0.001) and medial femur (mean difference 0.36 msec [95{\%} CI 0.27, 0.81]; P = 0.006) compared to controls. Averaged over all compartments, DM subjects showed significantly higher texture parameters (variance, P = 0.001; contrast, P = 0.002; entropy, P < 0.001). Subjects with severe DM additionally showed higher T2 in the medial tibial deep and superficial layers (P = 0.011 and P = 0.041) compared to controls. No significant differences in cartilage, meniscus, and overall WORMS were found between the groups (P > 0.05). Conclusion: In comparison to nondiabetic controls, cartilage in DM subjects showed higher and more heterogeneous cartilage T2 values, indicating increased articular cartilage degeneration. This affected even more compartments in subjects with severe DM.",
keywords = "Cartilage imaging, Diabetes, Knee osteoarthritis, Magnetic resonance imaging",
author = "Nattagan Chanchek and Gersing, {Alexandra S.} and Schwaiger, {Benedikt J.} and Nevitt, {Michael C.} and Jan Neumann and Joseph, {Gabby B.} and Lane, {Nancy E} and Julia Zarnowski and Hofmann, {Felix C.} and Ursula Heilmeier and Mcculloch, {Charles E.} and Link, {Thomas M.}",
year = "2017",
doi = "10.1002/jmri.25766",
language = "English (US)",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",

}

TY - JOUR

T1 - Association of diabetes mellitus and biochemical knee cartilage composition assessed by T2 relaxation time measurements

T2 - Data from the osteoarthritis initiative

AU - Chanchek, Nattagan

AU - Gersing, Alexandra S.

AU - Schwaiger, Benedikt J.

AU - Nevitt, Michael C.

AU - Neumann, Jan

AU - Joseph, Gabby B.

AU - Lane, Nancy E

AU - Zarnowski, Julia

AU - Hofmann, Felix C.

AU - Heilmeier, Ursula

AU - Mcculloch, Charles E.

AU - Link, Thomas M.

PY - 2017

Y1 - 2017

N2 - Purpose: To investigate the association of the presence and severity of diabetes mellitus (DM) with articular cartilage composition, using magnetic resonance imaging (MRI)-based T2 relaxation time measurements, and structural knee abnormalities. Materials and Methods: In the Osteoarthritis Initiative 208, participants with DM (age 63.0 ± 8.9 years; 111 females) and risk factors for osteoarthritis (OA) or mild radiographic tibiofemoral OA (Kellgren-Lawrence [KL] grade ≤2) were identified and group-matched with 208 controls without DM (age 63.3 ± 9.1 years; 111 females). Subjects with diabetes-related renal or ophthalmological complications or insulin treatment at baseline (n = 50) were defined as severe DM. 3T MR images of the right knee were assessed for articular cartilage T2, including texture and laminar analyses derived from the patella, medial, and lateral femur and tibia and for structural abnormalities using the modified whole-organ magnetic resonance imaging score (WORMS). Clustered linear regression analyses were used to assess associations of DM with MRI findings. Results: DM subjects had significantly higher cartilage T2 in the patella (mean difference 0.92 msec [95% confidence interval (CI) 0.79, 1.06]; P = 0.001) and medial femur (mean difference 0.36 msec [95% CI 0.27, 0.81]; P = 0.006) compared to controls. Averaged over all compartments, DM subjects showed significantly higher texture parameters (variance, P = 0.001; contrast, P = 0.002; entropy, P < 0.001). Subjects with severe DM additionally showed higher T2 in the medial tibial deep and superficial layers (P = 0.011 and P = 0.041) compared to controls. No significant differences in cartilage, meniscus, and overall WORMS were found between the groups (P > 0.05). Conclusion: In comparison to nondiabetic controls, cartilage in DM subjects showed higher and more heterogeneous cartilage T2 values, indicating increased articular cartilage degeneration. This affected even more compartments in subjects with severe DM.

AB - Purpose: To investigate the association of the presence and severity of diabetes mellitus (DM) with articular cartilage composition, using magnetic resonance imaging (MRI)-based T2 relaxation time measurements, and structural knee abnormalities. Materials and Methods: In the Osteoarthritis Initiative 208, participants with DM (age 63.0 ± 8.9 years; 111 females) and risk factors for osteoarthritis (OA) or mild radiographic tibiofemoral OA (Kellgren-Lawrence [KL] grade ≤2) were identified and group-matched with 208 controls without DM (age 63.3 ± 9.1 years; 111 females). Subjects with diabetes-related renal or ophthalmological complications or insulin treatment at baseline (n = 50) were defined as severe DM. 3T MR images of the right knee were assessed for articular cartilage T2, including texture and laminar analyses derived from the patella, medial, and lateral femur and tibia and for structural abnormalities using the modified whole-organ magnetic resonance imaging score (WORMS). Clustered linear regression analyses were used to assess associations of DM with MRI findings. Results: DM subjects had significantly higher cartilage T2 in the patella (mean difference 0.92 msec [95% confidence interval (CI) 0.79, 1.06]; P = 0.001) and medial femur (mean difference 0.36 msec [95% CI 0.27, 0.81]; P = 0.006) compared to controls. Averaged over all compartments, DM subjects showed significantly higher texture parameters (variance, P = 0.001; contrast, P = 0.002; entropy, P < 0.001). Subjects with severe DM additionally showed higher T2 in the medial tibial deep and superficial layers (P = 0.011 and P = 0.041) compared to controls. No significant differences in cartilage, meniscus, and overall WORMS were found between the groups (P > 0.05). Conclusion: In comparison to nondiabetic controls, cartilage in DM subjects showed higher and more heterogeneous cartilage T2 values, indicating increased articular cartilage degeneration. This affected even more compartments in subjects with severe DM.

KW - Cartilage imaging

KW - Diabetes

KW - Knee osteoarthritis

KW - Magnetic resonance imaging

UR - http://www.scopus.com/inward/record.url?scp=85019765579&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85019765579&partnerID=8YFLogxK

U2 - 10.1002/jmri.25766

DO - 10.1002/jmri.25766

M3 - Article

C2 - 28556419

AN - SCOPUS:85019765579

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

ER -