Association of diabetes, homocysteine, and HDL with cognition and disability after stroke

George C. Newman, Heejung Bang, Syed I. Hussain, James F. Toole

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


OBJECTIVE: To delineate factors associated with cognitive function following stroke and test the hypothesis that vascular risk factors associated with oxidative stress impair recovery. METHOD: We performed a post hoc analysis of the extensive longitudinal database from the 3,680 subjects (over 35 years old) entered between 1996 and 2003 into the Vitamin Intervention for Stroke Prevention trial using a linear mixed effects model. The primary outcome variables were scores on the Mini-Mental State Examination (MMSE) and modified Rankin Scale (mRS). RESULTS: MMSE and mRS gradually improved during the 2-year follow-up period. Increased age and nonwhite race, recurrent stroke, diabetes mellitus, left hemisphere cortical lesions, and values of high-density lipoprotein and homocysteine were independent predictors of less successful cognitive recovery. A strong interaction between homocysteine and age indicated a threshold effect beginning in the late 50s. No vitamin treatment effects were identified. Similar factors were identified for recovery of disability as assessed by the mRS, although there were qualitative and quantitative differences. CONCLUSIONS: The finding that diabetes, high-density lipoprotein, and homocysteine predict poorer cognitive function and greater disability after stroke is consistent with the hypothesis that metabolic stress plays a significant role in the poststroke period.

Original languageEnglish (US)
Pages (from-to)2054-2062
Number of pages9
Issue number22
StatePublished - Nov 2007
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'Association of diabetes, homocysteine, and HDL with cognition and disability after stroke'. Together they form a unique fingerprint.

Cite this