Association of complement sensitivity with virulence of Pasteurella multocida isolated from turkeys.

K. P. Snipes, D. C. Hirsh

Research output: Contribution to journalArticle

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Two strains of Pasteurella multocida, both derivatives of strain P1059, were compared for virulence for 14-week-old turkeys and sensitivity to turkey plasma. Strain P1059-1, a nalidixic-acid-resistant mutant of P1059 with an LD50 of approximately 10(3) colony-forming units (CFU), was more resistant to the bactericidal effects of fresh turkey plasma at 37 C than avirulent strain P1059-1A. P1059-1A, with an LD50 of approximately 10(8) CFU, is an acapsular variant of P1059-1 that spontaneously arose after prolonged passage on artificial medium. The bactericidal effect on P1059-1A was removed when turkey plasma was treated with heat or with zymosan, maneuvers that removed hemolytic complement activity from turkey plasma.

Original languageEnglish (US)
Pages (from-to)500-504
Number of pages5
JournalAvian Diseases
Issue number3
StatePublished - Jul 1986
Externally publishedYes


ASJC Scopus subject areas

  • Cancer Research
  • Immunology
  • veterinary(all)

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