Association of complement sensitivity with virulence of Pasteurella multocida isolated from turkeys.

K. P. Snipes, D. C. Hirsh

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Two strains of Pasteurella multocida, both derivatives of strain P1059, were compared for virulence for 14-week-old turkeys and sensitivity to turkey plasma. Strain P1059-1, a nalidixic-acid-resistant mutant of P1059 with an LD50 of approximately 10(3) colony-forming units (CFU), was more resistant to the bactericidal effects of fresh turkey plasma at 37 C than avirulent strain P1059-1A. P1059-1A, with an LD50 of approximately 10(8) CFU, is an acapsular variant of P1059-1 that spontaneously arose after prolonged passage on artificial medium. The bactericidal effect on P1059-1A was removed when turkey plasma was treated with heat or with zymosan, maneuvers that removed hemolytic complement activity from turkey plasma.

Original languageEnglish (US)
Pages (from-to)500-504
Number of pages5
JournalAvian Diseases
Volume30
Issue number3
StatePublished - Jul 1986
Externally publishedYes

Fingerprint

Pasteurella multocida
Virulence
complement
virulence
antibacterial properties
Lethal Dose 50
lethal dose 50
Stem Cells
zymosan
Nalidixic Acid
Zymosan
nalidixic acid
avirulent strains
Complement System Proteins
Hot Temperature
heat
mutants

ASJC Scopus subject areas

  • Cancer Research
  • Immunology
  • veterinary(all)

Cite this

Association of complement sensitivity with virulence of Pasteurella multocida isolated from turkeys. / Snipes, K. P.; Hirsh, D. C.

In: Avian Diseases, Vol. 30, No. 3, 07.1986, p. 500-504.

Research output: Contribution to journalArticle

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