Abstract
Background. Persistent infection with oncogenic human papillomavirus (HPV) is associated with an increased risk of cervical malignancy. Redetection of type-specific HPV after a period of nondetection may be caused by reactivation of a low-level persistent infection. Little is known about factors associated with type-specific HPV redetection.Methods. For a longitudinal cohort of adolescent women with frequent behavioral and sexually transmitted infection (STI) information (every 3 months), Cox proportional hazard models were used to assess the influence of sexual behaviors and STIs on the redetection of oncogenic or high-risk HPV infections.Results. A total of 210 type-specific high-risk HPV detection episode periods were identified in this longitudinal cohort; 71 (33.8%) were characterized by a period of nondetection followed by redetection. Chlamydia trachomatis (hazard ratio [HR], 3.14; 95% confidence interval [CI], 1.44-6.86) was associated with redetection; redetection was >2 times more likely with each additional self-reported sex partner in the past 3 months (HR, 2.26; 95% CI, 1.35-3.78).Conclusions. This study demonstrates the role of C. trachomatis and number of recent sexual partners in type-specific HPV redetection. Given that persistent oncogenic HPV infections are associated with cancer-related outcomes, understanding the potential role of such factors in the pathogenesis of HPV-related outcomes is important.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1416-1421 |
| Number of pages | 6 |
| Journal | Journal of Infectious Diseases |
| Volume | 208 |
| Issue number | 9 |
| DOIs | |
| State | Published - Nov 1 2013 |
| Externally published | Yes |
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Keywords
- chlamydia
- HPV redetection
- human papillomavirus
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases
Cite this
Association of chlamydia trachomatis infection with redetection of human papillomavirus after apparent clearance. / Shew, Marcia L.; Ermel, Aaron C.; Weaver, Bree A.; Tong, Yan; Tu, Wanzhu; Kester, Laura; Denski, Cheryl; Fortenberry, J. D.; Brown, Darron R.
In: Journal of Infectious Diseases, Vol. 208, No. 9, 01.11.2013, p. 1416-1421.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of chlamydia trachomatis infection with redetection of human papillomavirus after apparent clearance
AU - Shew, Marcia L.
AU - Ermel, Aaron C.
AU - Weaver, Bree A.
AU - Tong, Yan
AU - Tu, Wanzhu
AU - Kester, Laura
AU - Denski, Cheryl
AU - Fortenberry, J. D.
AU - Brown, Darron R.
PY - 2013/11/1
Y1 - 2013/11/1
N2 - Background. Persistent infection with oncogenic human papillomavirus (HPV) is associated with an increased risk of cervical malignancy. Redetection of type-specific HPV after a period of nondetection may be caused by reactivation of a low-level persistent infection. Little is known about factors associated with type-specific HPV redetection.Methods. For a longitudinal cohort of adolescent women with frequent behavioral and sexually transmitted infection (STI) information (every 3 months), Cox proportional hazard models were used to assess the influence of sexual behaviors and STIs on the redetection of oncogenic or high-risk HPV infections.Results. A total of 210 type-specific high-risk HPV detection episode periods were identified in this longitudinal cohort; 71 (33.8%) were characterized by a period of nondetection followed by redetection. Chlamydia trachomatis (hazard ratio [HR], 3.14; 95% confidence interval [CI], 1.44-6.86) was associated with redetection; redetection was >2 times more likely with each additional self-reported sex partner in the past 3 months (HR, 2.26; 95% CI, 1.35-3.78).Conclusions. This study demonstrates the role of C. trachomatis and number of recent sexual partners in type-specific HPV redetection. Given that persistent oncogenic HPV infections are associated with cancer-related outcomes, understanding the potential role of such factors in the pathogenesis of HPV-related outcomes is important.
AB - Background. Persistent infection with oncogenic human papillomavirus (HPV) is associated with an increased risk of cervical malignancy. Redetection of type-specific HPV after a period of nondetection may be caused by reactivation of a low-level persistent infection. Little is known about factors associated with type-specific HPV redetection.Methods. For a longitudinal cohort of adolescent women with frequent behavioral and sexually transmitted infection (STI) information (every 3 months), Cox proportional hazard models were used to assess the influence of sexual behaviors and STIs on the redetection of oncogenic or high-risk HPV infections.Results. A total of 210 type-specific high-risk HPV detection episode periods were identified in this longitudinal cohort; 71 (33.8%) were characterized by a period of nondetection followed by redetection. Chlamydia trachomatis (hazard ratio [HR], 3.14; 95% confidence interval [CI], 1.44-6.86) was associated with redetection; redetection was >2 times more likely with each additional self-reported sex partner in the past 3 months (HR, 2.26; 95% CI, 1.35-3.78).Conclusions. This study demonstrates the role of C. trachomatis and number of recent sexual partners in type-specific HPV redetection. Given that persistent oncogenic HPV infections are associated with cancer-related outcomes, understanding the potential role of such factors in the pathogenesis of HPV-related outcomes is important.
KW - chlamydia
KW - HPV redetection
KW - human papillomavirus
UR - http://www.scopus.com/inward/record.url?scp=84885405926&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84885405926&partnerID=8YFLogxK
U2 - 10.1093/infdis/jit346
DO - 10.1093/infdis/jit346
M3 - Article
VL - 208
SP - 1416
EP - 1421
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 9
ER -