Association of chlamydia trachomatis infection with redetection of human papillomavirus after apparent clearance

Marcia L. Shew, Aaron C. Ermel, Bree A. Weaver, Yan Tong, Wanzhu Tu, Laura Kester, Cheryl Denski, J. D. Fortenberry, Darron R. Brown

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Background. Persistent infection with oncogenic human papillomavirus (HPV) is associated with an increased risk of cervical malignancy. Redetection of type-specific HPV after a period of nondetection may be caused by reactivation of a low-level persistent infection. Little is known about factors associated with type-specific HPV redetection.Methods. For a longitudinal cohort of adolescent women with frequent behavioral and sexually transmitted infection (STI) information (every 3 months), Cox proportional hazard models were used to assess the influence of sexual behaviors and STIs on the redetection of oncogenic or high-risk HPV infections.Results. A total of 210 type-specific high-risk HPV detection episode periods were identified in this longitudinal cohort; 71 (33.8%) were characterized by a period of nondetection followed by redetection. Chlamydia trachomatis (hazard ratio [HR], 3.14; 95% confidence interval [CI], 1.44-6.86) was associated with redetection; redetection was >2 times more likely with each additional self-reported sex partner in the past 3 months (HR, 2.26; 95% CI, 1.35-3.78).Conclusions. This study demonstrates the role of C. trachomatis and number of recent sexual partners in type-specific HPV redetection. Given that persistent oncogenic HPV infections are associated with cancer-related outcomes, understanding the potential role of such factors in the pathogenesis of HPV-related outcomes is important.

Original languageEnglish (US)
Pages (from-to)1416-1421
Number of pages6
JournalJournal of Infectious Diseases
Issue number9
StatePublished - Nov 1 2013
Externally publishedYes


  • chlamydia
  • HPV redetection
  • human papillomavirus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


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