Association of CD20+ infiltrates with poorer clinical outcomes in acute cellular rejection of renal allografts

Benjamin E. Hippen, Angelo M DeMattos, William J. Cook, Clifton E. Kew, Robert S. Gaston

Research output: Contribution to journalArticle

122 Scopus citations

Abstract

We undertook a study to ascertain the relationship between the presence of CD20-positive B-lymphocytes in renal allografts undergoing acute cellular rejection and graft survival. We identified 27 patients transplanted between January 1, 1998 and December 31, 2001, with biopsy-proven Banff 1-A or Banff 1-B rejection in the first year after transplantation, and stained the specimens for CD20 and C4d. At least 4 years of follow-up data were available for each patient studied. Six patients had CD20-positive B-cell clusters in the interstitium, and 21 patients were negative for CD20 infiltrates. The CD20-positive group was significantly more likely to have steroid-resistant rejection and reduced graft survival compared to CD20-negative controls. This study supports prospective identification of CD20-positive B-cell clusters in biopsy-proven rejection and offers a therapeutic rationale for a trial of monoclonal anti-CD20 antibody in such patients.

Original languageEnglish (US)
Pages (from-to)2248-2252
Number of pages5
JournalAmerican Journal of Transplantation
Volume5
Issue number9
DOIs
StatePublished - Sep 2005
Externally publishedYes

Keywords

  • B-cells
  • Biopsy
  • Graft survival
  • Kidney transplantation
  • Rejection

ASJC Scopus subject areas

  • Immunology

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