Association of cartilage degeneration with four year weight gain - 3T MRI data from the Osteoarthritis Initiative

M. D. Bucknor, Lorenzo Nardo, G. B. Joseph, H. Alizai, W. Srikhum, M. C. Nevitt, J. A. Lynch, C. E. McCulloch, T. M. Link

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective: To determine the effect of weight gain on progression of early knee morphologic abnormalities using magnetic resonance imaging (MRI) in a longitudinal study over 48 months. Design: We studied the right knee of 100 subjects from the Osteoarthritis Initiative (OAI), selecting subjects aged ≥45 with osteoarthritis (OA) risk factors who demonstrated weight gain (minimum 5% increase in body mass index, BMI, n=50) or no change in weight (BMI change<2%, n=50), frequency matched for age, gender, and baseline BMI. Baseline and 48 month knee MRI studies were scored for lesions using a modified whole organ MRI score (WORMS). Logistic regression models were used to compare the differences between the two groups. Results: The odds of worsening maximum cartilage (11.3, 95%, CI 3.5-51.4) and meniscal WORMS (4.5, 95% CI 1.4-17.3) were significantly greater in the weight gain group compared to the no change group, in addition to the odds of worsening cartilage defects at the patella and average meniscal WORMS (P<0.05). Odds of worsening average bone marrow edema pattern (BMEP) were significantly greater for the weight gain group compared to the no change cohort (P<0.05). Conclusion: Our study demonstrated that weight gain is strongly associated with increased progression of cartilage degeneration in middle-aged individuals with risk factors for OA.

Original languageEnglish (US)
Pages (from-to)525-531
Number of pages7
JournalOsteoarthritis and Cartilage
Volume23
Issue number4
DOIs
StatePublished - Apr 1 2015
Externally publishedYes

Fingerprint

Cartilage
Magnetic resonance
Osteoarthritis
Weight Gain
Magnetic Resonance Imaging
Imaging techniques
Magnetic resonance imaging
Knee
Logistic Models
Logistics
Bone
Patella
Defects
Longitudinal Studies
Edema
Body Mass Index
Bone Marrow
Weights and Measures

Keywords

  • Cartilage degeneration
  • Osteoarthritis
  • Weight gain
  • Whole organ MRI score

ASJC Scopus subject areas

  • Rheumatology
  • Orthopedics and Sports Medicine
  • Biomedical Engineering

Cite this

Association of cartilage degeneration with four year weight gain - 3T MRI data from the Osteoarthritis Initiative. / Bucknor, M. D.; Nardo, Lorenzo; Joseph, G. B.; Alizai, H.; Srikhum, W.; Nevitt, M. C.; Lynch, J. A.; McCulloch, C. E.; Link, T. M.

In: Osteoarthritis and Cartilage, Vol. 23, No. 4, 01.04.2015, p. 525-531.

Research output: Contribution to journalArticle

Bucknor, MD, Nardo, L, Joseph, GB, Alizai, H, Srikhum, W, Nevitt, MC, Lynch, JA, McCulloch, CE & Link, TM 2015, 'Association of cartilage degeneration with four year weight gain - 3T MRI data from the Osteoarthritis Initiative', Osteoarthritis and Cartilage, vol. 23, no. 4, pp. 525-531. https://doi.org/10.1016/j.joca.2014.10.013
Bucknor, M. D. ; Nardo, Lorenzo ; Joseph, G. B. ; Alizai, H. ; Srikhum, W. ; Nevitt, M. C. ; Lynch, J. A. ; McCulloch, C. E. ; Link, T. M. / Association of cartilage degeneration with four year weight gain - 3T MRI data from the Osteoarthritis Initiative. In: Osteoarthritis and Cartilage. 2015 ; Vol. 23, No. 4. pp. 525-531.
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