Association of body fat distribution and family histories of breast and ovarian cancer with risk of postmenopausal breast cancer

Thomas A. Sellers, Susan M. Gapstur, John D. Potter, Lawrence H. Kushi, Roberd M. Bostick, Aaron R. Folsom

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The authors recently published data from a prospective cohort study of postmeno-pausal women (N Engl J Med 1992; 326:1323-9) which suggested that a high waist/hip ratio was associated with a significantly increased risk of breast cancer in women with a positive family history of breast cancer. Since families with aggregations of breast and ovarian cancer demonstrate more consistent genetic linkage to markers on chromosome 17q than do families with breast cancer alone, the authors performed additional analyses to examine whether the previously observed associations with waist/hip ratio differed when family history of breast cancer was partitioned according to whether or not ovanan cancer was also present in a close relative. Between 1986 and 1990,620 incident cases of breast cancer were identified in a cohort of 37,105 postmenopausal Iowa women A family history of breast cancer in first-degree relatives was associated with a relative risk of 1.34 (95% confidence interval (CI) 1.07-1 69), a family history of both breast and ovarian cancer was associated with a relative risk of 2.36 (95% CI 1.12-4.98). Consistent with the authors' findings after 4 years of follow-up, a high waist/hip ratio (>80th percentile vs. <80th percentile) was associated with increased risk of breast cancer in the presence of a family history of breast cancer (relative risk (RR) = 2.10, 95% Cl 1.43-3.09) but not in the absence of a family history of breast cancer (RR = 1.12). The combination of a high waist/hip ratio with a family history of breast and ovanan cancer was associated with 4.83-fold increased risk (95% Cl 1.55-15.1). Neither a family history of breast cancer nor a family history of ovanan cancer was associated with significantly increased nsk in the absence of a high waist/hip ratio. Am J Epidemiol 1993; 138:799-803.

Original languageEnglish (US)
Pages (from-to)799-803
Number of pages5
JournalAmerican Journal of Epidemiology
Volume138
Issue number10
StatePublished - Nov 15 1993
Externally publishedYes

Fingerprint

Body Fat Distribution
Ovarian Neoplasms
Breast Neoplasms
Waist-Hip Ratio
Confidence Intervals
Genetic Linkage
Genetic Markers

Keywords

  • Anthropometry
  • Breast neoplasms
  • Obesity
  • Ovanan neoplasms
  • Prospective studies

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Epidemiology

Cite this

Sellers, T. A., Gapstur, S. M., Potter, J. D., Kushi, L. H., Bostick, R. M., & Folsom, A. R. (1993). Association of body fat distribution and family histories of breast and ovarian cancer with risk of postmenopausal breast cancer. American Journal of Epidemiology, 138(10), 799-803.

Association of body fat distribution and family histories of breast and ovarian cancer with risk of postmenopausal breast cancer. / Sellers, Thomas A.; Gapstur, Susan M.; Potter, John D.; Kushi, Lawrence H.; Bostick, Roberd M.; Folsom, Aaron R.

In: American Journal of Epidemiology, Vol. 138, No. 10, 15.11.1993, p. 799-803.

Research output: Contribution to journalArticle

Sellers, TA, Gapstur, SM, Potter, JD, Kushi, LH, Bostick, RM & Folsom, AR 1993, 'Association of body fat distribution and family histories of breast and ovarian cancer with risk of postmenopausal breast cancer', American Journal of Epidemiology, vol. 138, no. 10, pp. 799-803.
Sellers, Thomas A. ; Gapstur, Susan M. ; Potter, John D. ; Kushi, Lawrence H. ; Bostick, Roberd M. ; Folsom, Aaron R. / Association of body fat distribution and family histories of breast and ovarian cancer with risk of postmenopausal breast cancer. In: American Journal of Epidemiology. 1993 ; Vol. 138, No. 10. pp. 799-803.
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abstract = "The authors recently published data from a prospective cohort study of postmeno-pausal women (N Engl J Med 1992; 326:1323-9) which suggested that a high waist/hip ratio was associated with a significantly increased risk of breast cancer in women with a positive family history of breast cancer. Since families with aggregations of breast and ovarian cancer demonstrate more consistent genetic linkage to markers on chromosome 17q than do families with breast cancer alone, the authors performed additional analyses to examine whether the previously observed associations with waist/hip ratio differed when family history of breast cancer was partitioned according to whether or not ovanan cancer was also present in a close relative. Between 1986 and 1990,620 incident cases of breast cancer were identified in a cohort of 37,105 postmenopausal Iowa women A family history of breast cancer in first-degree relatives was associated with a relative risk of 1.34 (95{\%} confidence interval (CI) 1.07-1 69), a family history of both breast and ovarian cancer was associated with a relative risk of 2.36 (95{\%} CI 1.12-4.98). Consistent with the authors' findings after 4 years of follow-up, a high waist/hip ratio (>80th percentile vs. <80th percentile) was associated with increased risk of breast cancer in the presence of a family history of breast cancer (relative risk (RR) = 2.10, 95{\%} Cl 1.43-3.09) but not in the absence of a family history of breast cancer (RR = 1.12). The combination of a high waist/hip ratio with a family history of breast and ovanan cancer was associated with 4.83-fold increased risk (95{\%} Cl 1.55-15.1). Neither a family history of breast cancer nor a family history of ovanan cancer was associated with significantly increased nsk in the absence of a high waist/hip ratio. Am J Epidemiol 1993; 138:799-803.",
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