Association of bluetongue virus gene segment 5 with neuroinvasiveness

Margaret A. Carr, Cecilia C. De Mattos, Carlos A. De Mattos, Bennie Osburn

Research output: Contribution to journalComment/debatepeer-review

13 Scopus citations

Abstract

Two strains (UC-2 and UC-8) of bluetongue virus were used to determine genetic factors influencing neuroinvasiveness. Reassortants were produced in vitro, and the parental origins of their genes were determined by polyacrylamide gel electrophoresis profiles and restriction endonuclease digestion. Gene segment 5 of UC-8 correlated with neuroinvasiveness of reassortants when inoculated subcutaneously into newborn mice.

Original languageEnglish (US)
Pages (from-to)1255-1257
Number of pages3
JournalJournal of Virology
Volume68
Issue number2
StatePublished - Feb 1 1994

ASJC Scopus subject areas

  • Immunology

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