Association between obesity and psychiatric disorders in the US adult population

Gregory E. Simon, Michael Von Korff, Kathleen Saunders, Diana L Miglioretti, Paul K. Crane, Gerald Van Belle, Ronald C. Kessler

Research output: Contribution to journalArticle

782 Citations (Scopus)

Abstract

Background: Epidemiologic data suggest an association between obesity and depression, but findings vary across studies and suggest a stronger relationship in women than men. Objective: To evaluate the relationship between obesity and a range of mood, anxiety, and substance use disorders in the US general population. Design: Cross-sectional epidemiologic survey. Setting: Nationally representative sample of US adults. Participants: A total of 9125 respondents who provided complete data on psychiatric disorder, height, and weight. Response rate was 70.9%. Main Outcome Measures: Participants completed an in-person interview, including assessment of a range of mental disorders (assessed using the World Health Organization Composite International Diagnostic Interview) and height and weight (by self-report). Results: Obesity (defined as body mass index [calculated as weight in kilograms divided by the square of height in meters] of ≥ 30) was associated with significant increases in lifetime diagnosis of major depression (odds ratio [OR], 1.21; 95% confidence interval [CI], 1.09-1.35), bipolar disorder (OR, 1.47; 95% CI, 1.12-1.93), and panic disorder or agoraphobia (OR, 1.27;95%CI, 1.01-1.60). Obesity was associated with significantly lower lifetime risk of substance use disorder (OR, 0.78; 95% CI, 0.65-0.93). Subgroup analyses found no difference in these associations between men and women, but the association between obesity and mood disorder was strongest in non-Hispanic whites (OR,1.38; 95% CI, 1.20-1.59) and college graduates (OR, 1.44; 95% CI, 1.14-1.81). Conclusions: Obesity is associated with an approximately 25% increase in odds of mood and anxiety disorders and an approximately 25% decrease in odds of substance use disorders. Variation across demographic groups suggests that social or cultural factors may moderate or mediate the association between obesity and mood disorder.

Original languageEnglish (US)
Pages (from-to)824-830
Number of pages7
JournalArchives of General Psychiatry
Volume63
Issue number7
DOIs
StatePublished - 2006
Externally publishedYes

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Psychiatry
Obesity
Odds Ratio
Confidence Intervals
Population
Mood Disorders
Substance-Related Disorders
Weights and Measures
Interviews
Depression
Agoraphobia
Panic Disorder
Anxiety Disorders
Bipolar Disorder
Mental Disorders
Self Report
Body Mass Index
Anxiety
Cross-Sectional Studies
Demography

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Simon, G. E., Von Korff, M., Saunders, K., Miglioretti, D. L., Crane, P. K., Van Belle, G., & Kessler, R. C. (2006). Association between obesity and psychiatric disorders in the US adult population. Archives of General Psychiatry, 63(7), 824-830. https://doi.org/10.1001/archpsyc.63.7.824

Association between obesity and psychiatric disorders in the US adult population. / Simon, Gregory E.; Von Korff, Michael; Saunders, Kathleen; Miglioretti, Diana L; Crane, Paul K.; Van Belle, Gerald; Kessler, Ronald C.

In: Archives of General Psychiatry, Vol. 63, No. 7, 2006, p. 824-830.

Research output: Contribution to journalArticle

Simon, GE, Von Korff, M, Saunders, K, Miglioretti, DL, Crane, PK, Van Belle, G & Kessler, RC 2006, 'Association between obesity and psychiatric disorders in the US adult population', Archives of General Psychiatry, vol. 63, no. 7, pp. 824-830. https://doi.org/10.1001/archpsyc.63.7.824
Simon, Gregory E. ; Von Korff, Michael ; Saunders, Kathleen ; Miglioretti, Diana L ; Crane, Paul K. ; Van Belle, Gerald ; Kessler, Ronald C. / Association between obesity and psychiatric disorders in the US adult population. In: Archives of General Psychiatry. 2006 ; Vol. 63, No. 7. pp. 824-830.
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abstract = "Background: Epidemiologic data suggest an association between obesity and depression, but findings vary across studies and suggest a stronger relationship in women than men. Objective: To evaluate the relationship between obesity and a range of mood, anxiety, and substance use disorders in the US general population. Design: Cross-sectional epidemiologic survey. Setting: Nationally representative sample of US adults. Participants: A total of 9125 respondents who provided complete data on psychiatric disorder, height, and weight. Response rate was 70.9{\%}. Main Outcome Measures: Participants completed an in-person interview, including assessment of a range of mental disorders (assessed using the World Health Organization Composite International Diagnostic Interview) and height and weight (by self-report). Results: Obesity (defined as body mass index [calculated as weight in kilograms divided by the square of height in meters] of ≥ 30) was associated with significant increases in lifetime diagnosis of major depression (odds ratio [OR], 1.21; 95{\%} confidence interval [CI], 1.09-1.35), bipolar disorder (OR, 1.47; 95{\%} CI, 1.12-1.93), and panic disorder or agoraphobia (OR, 1.27;95{\%}CI, 1.01-1.60). Obesity was associated with significantly lower lifetime risk of substance use disorder (OR, 0.78; 95{\%} CI, 0.65-0.93). Subgroup analyses found no difference in these associations between men and women, but the association between obesity and mood disorder was strongest in non-Hispanic whites (OR,1.38; 95{\%} CI, 1.20-1.59) and college graduates (OR, 1.44; 95{\%} CI, 1.14-1.81). Conclusions: Obesity is associated with an approximately 25{\%} increase in odds of mood and anxiety disorders and an approximately 25{\%} decrease in odds of substance use disorders. Variation across demographic groups suggests that social or cultural factors may moderate or mediate the association between obesity and mood disorder.",
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