Association between obesity and atopic dermatitis in childhood

A case-control study

Jonathan I. Silverberg, Edward Kleiman, Hadar Lev-Tov, Nanette B. Silverberg, Helen G. Durkin, Rauno Joks, Tamar A. Smith-Norowitz

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Background: Obesity in children is associated with increased asthma and atopy. Objective: We sought to determine whether obesity in childhood or adolescence increases the risk of atopic dermatitis. Methods: This retrospective, practice-based, case-control study randomly sampled 414 children and adolescents (age, 1-21 years) with atopic dermatitis between January 2000 and December 2007 and 828 randomly sampled healthy control subjects. Information was obtained from an electronic medical record. Observations were made before the a priori hypothesis. Results: Obesity in children is associated with increased atopic dermatitis (conditional logistic regression: odds ratio, 2.00; 95% CI, 1.22-3.26; P = .006). These atopic dermatitis-predisposing effects are found when obesity started by less than 2 years of age (adjusted odds ratio [aOR], 15.10; 95% CI, 1.51-151.21; P = .02) and 2 to 5 years (aOR, 2.58; 95% CI, 1.24-5.41; P = .01) but not greater than 5 years (aOR, 1.32; 95% CI, 0.66-2.64; P = .43) and when obesity was prolonged for 2.5 to 5 years (aOR, 2.64; 95% CI, 1.13-6.18; P = .03) and greater than 5 years (aOR, 3.40; 95% CI, 1.34-8.63; P = 0.01). Obesity is associated with more severe atopic dermatitis (ordinal logistic regression: aOR, 2.37; 95% CI, 1.24-5.37; P = .01). Obese children who eventually have atopic dermatitis require more frequent pediatrician visits for the management of atopic dermatitis (ordinal logistic regression: aOR, 2.22; 95% CI, 1.12-4.50; P = .03). Conclusion: Prolonged obesity in early childhood is a risk factor for atopic dermatitis. Weight loss might be an important approach for the prevention and treatment of atopic dermatitis in children.

Original languageEnglish (US)
Pages (from-to)1180-1186
Number of pages7
JournalJournal of Allergy and Clinical Immunology
Volume127
Issue number5
DOIs
StatePublished - May 2011
Externally publishedYes

Fingerprint

Atopic Dermatitis
Case-Control Studies
Obesity
Odds Ratio
Pediatric Obesity
Logistic Models
Electronic Health Records
Weight Loss
Healthy Volunteers
Asthma

Keywords

  • Atopic dermatitis
  • atopy
  • body mass index
  • eczema
  • obesity
  • overweight
  • weight

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Silverberg, J. I., Kleiman, E., Lev-Tov, H., Silverberg, N. B., Durkin, H. G., Joks, R., & Smith-Norowitz, T. A. (2011). Association between obesity and atopic dermatitis in childhood: A case-control study. Journal of Allergy and Clinical Immunology, 127(5), 1180-1186. https://doi.org/10.1016/j.jaci.2011.01.063

Association between obesity and atopic dermatitis in childhood : A case-control study. / Silverberg, Jonathan I.; Kleiman, Edward; Lev-Tov, Hadar; Silverberg, Nanette B.; Durkin, Helen G.; Joks, Rauno; Smith-Norowitz, Tamar A.

In: Journal of Allergy and Clinical Immunology, Vol. 127, No. 5, 05.2011, p. 1180-1186.

Research output: Contribution to journalArticle

Silverberg, JI, Kleiman, E, Lev-Tov, H, Silverberg, NB, Durkin, HG, Joks, R & Smith-Norowitz, TA 2011, 'Association between obesity and atopic dermatitis in childhood: A case-control study', Journal of Allergy and Clinical Immunology, vol. 127, no. 5, pp. 1180-1186. https://doi.org/10.1016/j.jaci.2011.01.063
Silverberg, Jonathan I. ; Kleiman, Edward ; Lev-Tov, Hadar ; Silverberg, Nanette B. ; Durkin, Helen G. ; Joks, Rauno ; Smith-Norowitz, Tamar A. / Association between obesity and atopic dermatitis in childhood : A case-control study. In: Journal of Allergy and Clinical Immunology. 2011 ; Vol. 127, No. 5. pp. 1180-1186.
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abstract = "Background: Obesity in children is associated with increased asthma and atopy. Objective: We sought to determine whether obesity in childhood or adolescence increases the risk of atopic dermatitis. Methods: This retrospective, practice-based, case-control study randomly sampled 414 children and adolescents (age, 1-21 years) with atopic dermatitis between January 2000 and December 2007 and 828 randomly sampled healthy control subjects. Information was obtained from an electronic medical record. Observations were made before the a priori hypothesis. Results: Obesity in children is associated with increased atopic dermatitis (conditional logistic regression: odds ratio, 2.00; 95{\%} CI, 1.22-3.26; P = .006). These atopic dermatitis-predisposing effects are found when obesity started by less than 2 years of age (adjusted odds ratio [aOR], 15.10; 95{\%} CI, 1.51-151.21; P = .02) and 2 to 5 years (aOR, 2.58; 95{\%} CI, 1.24-5.41; P = .01) but not greater than 5 years (aOR, 1.32; 95{\%} CI, 0.66-2.64; P = .43) and when obesity was prolonged for 2.5 to 5 years (aOR, 2.64; 95{\%} CI, 1.13-6.18; P = .03) and greater than 5 years (aOR, 3.40; 95{\%} CI, 1.34-8.63; P = 0.01). Obesity is associated with more severe atopic dermatitis (ordinal logistic regression: aOR, 2.37; 95{\%} CI, 1.24-5.37; P = .01). Obese children who eventually have atopic dermatitis require more frequent pediatrician visits for the management of atopic dermatitis (ordinal logistic regression: aOR, 2.22; 95{\%} CI, 1.12-4.50; P = .03). Conclusion: Prolonged obesity in early childhood is a risk factor for atopic dermatitis. Weight loss might be an important approach for the prevention and treatment of atopic dermatitis in children.",
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