Association between inflammatory airway disease of horses and exposure to respiratory viruses: A case control study

Ashley Houtsma, Daniela Bedenice, Nicola Pusterla, Brenna Pugliese, Samantha Mapes, Andrew M. Hoffman, Julia Paxson, Elizabeth Rozanski, Jean Mukherjee, Margaret Wigley, Melissa R. Mazan

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Inflammatory airway disease (IAD) in horses, similar to asthma in humans, is a common cause of chronic poor respiratory health and exercise intolerance due to airway inflammation and exaggerated airway constrictive responses. Human rhinovirus is an important trigger for the development of asthma; a similar role for viral respiratory disease in equine IAD has not been established yet. Methods: In a case-control study, horses with IAD (n = 24) were compared to control animals from comparable stabling environments (n = 14). Horses were classified using pulmonary function testing and bronchoalveolar lavage. PCR for equine rhinitis virus A and B (ERAV, ERBV), influenza virus (EIV), and herpesviruses 2, 4, and 5 (EHV-2, EHV-4, EHV-5) was performed on nasal swab, buffy coat from whole blood, and cells from BAL fluid (BALF), and serology were performed. Categorical variables were compared between IAD and control using Fisher's exact test; continuous variables were compared with an independent t-test. For all analyses, a value of P

Original languageEnglish (US)
Article number33
JournalMultidisciplinary Respiratory Medicine
Volume10
Issue number1
DOIs
StatePublished - Nov 3 2015

Fingerprint

Horse Diseases
Equid Herpesvirus 4
Horses
Case-Control Studies
Viruses
Erbovirus
Aphthovirus
Asthma
Dimercaprol
Rhinovirus
Airway Management
Herpesviridae
Bronchoalveolar Lavage
Virus Diseases
Serology
Orthomyxoviridae
Nose
Blood Cells
Inflammation
Polymerase Chain Reaction

Keywords

  • Asthma
  • Bronchoalveolar lavage
  • Equine herpesvirus-2
  • Equine rhinitis virus
  • Pulmonary function testing

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Association between inflammatory airway disease of horses and exposure to respiratory viruses : A case control study. / Houtsma, Ashley; Bedenice, Daniela; Pusterla, Nicola; Pugliese, Brenna; Mapes, Samantha; Hoffman, Andrew M.; Paxson, Julia; Rozanski, Elizabeth; Mukherjee, Jean; Wigley, Margaret; Mazan, Melissa R.

In: Multidisciplinary Respiratory Medicine, Vol. 10, No. 1, 33, 03.11.2015.

Research output: Contribution to journalArticle

Houtsma, A, Bedenice, D, Pusterla, N, Pugliese, B, Mapes, S, Hoffman, AM, Paxson, J, Rozanski, E, Mukherjee, J, Wigley, M & Mazan, MR 2015, 'Association between inflammatory airway disease of horses and exposure to respiratory viruses: A case control study', Multidisciplinary Respiratory Medicine, vol. 10, no. 1, 33. https://doi.org/10.1186/s40248-015-0030-3
Houtsma, Ashley ; Bedenice, Daniela ; Pusterla, Nicola ; Pugliese, Brenna ; Mapes, Samantha ; Hoffman, Andrew M. ; Paxson, Julia ; Rozanski, Elizabeth ; Mukherjee, Jean ; Wigley, Margaret ; Mazan, Melissa R. / Association between inflammatory airway disease of horses and exposure to respiratory viruses : A case control study. In: Multidisciplinary Respiratory Medicine. 2015 ; Vol. 10, No. 1.
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