TY - JOUR
T1 - Association between inflammatory airway disease of horses and exposure to respiratory viruses
T2 - A case control study
AU - Houtsma, Ashley
AU - Bedenice, Daniela
AU - Pusterla, Nicola
AU - Pugliese, Brenna
AU - Mapes, Samantha
AU - Hoffman, Andrew M.
AU - Paxson, Julia
AU - Rozanski, Elizabeth
AU - Mukherjee, Jean
AU - Wigley, Margaret
AU - Mazan, Melissa R.
PY - 2015/11/3
Y1 - 2015/11/3
N2 - Background: Inflammatory airway disease (IAD) in horses, similar to asthma in humans, is a common cause of chronic poor respiratory health and exercise intolerance due to airway inflammation and exaggerated airway constrictive responses. Human rhinovirus is an important trigger for the development of asthma; a similar role for viral respiratory disease in equine IAD has not been established yet. Methods: In a case-control study, horses with IAD (n = 24) were compared to control animals from comparable stabling environments (n = 14). Horses were classified using pulmonary function testing and bronchoalveolar lavage. PCR for equine rhinitis virus A and B (ERAV, ERBV), influenza virus (EIV), and herpesviruses 2, 4, and 5 (EHV-2, EHV-4, EHV-5) was performed on nasal swab, buffy coat from whole blood, and cells from BAL fluid (BALF), and serology were performed. Categorical variables were compared between IAD and control using Fisher's exact test; continuous variables were compared with an independent t-test. For all analyses, a value of P
AB - Background: Inflammatory airway disease (IAD) in horses, similar to asthma in humans, is a common cause of chronic poor respiratory health and exercise intolerance due to airway inflammation and exaggerated airway constrictive responses. Human rhinovirus is an important trigger for the development of asthma; a similar role for viral respiratory disease in equine IAD has not been established yet. Methods: In a case-control study, horses with IAD (n = 24) were compared to control animals from comparable stabling environments (n = 14). Horses were classified using pulmonary function testing and bronchoalveolar lavage. PCR for equine rhinitis virus A and B (ERAV, ERBV), influenza virus (EIV), and herpesviruses 2, 4, and 5 (EHV-2, EHV-4, EHV-5) was performed on nasal swab, buffy coat from whole blood, and cells from BAL fluid (BALF), and serology were performed. Categorical variables were compared between IAD and control using Fisher's exact test; continuous variables were compared with an independent t-test. For all analyses, a value of P
KW - Asthma
KW - Bronchoalveolar lavage
KW - Equine herpesvirus-2
KW - Equine rhinitis virus
KW - Pulmonary function testing
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U2 - 10.1186/s40248-015-0030-3
DO - 10.1186/s40248-015-0030-3
M3 - Article
AN - SCOPUS:84951906393
VL - 10
JO - Multidisciplinary Respiratory Medicine
JF - Multidisciplinary Respiratory Medicine
SN - 1828-695X
IS - 1
M1 - 33
ER -