Abstract
Cardiovascular disease is the leading cause of death among dialysis patients. The relative risk of mortality increases as serum albumin concentration and body mass index decline. While these are generally associated with nutritional status, inflammation causes sarcopenia and decreased albumin concentration by reducing synthesis of proteins and increasing their catabolic rate. While inflammation can arise from atherosclerotic blood vessels, systemic inflammation from any source can alter the vascular endothelium and plasma protein composition in ways that promotes vascular injury. High-density lipoprotein synthesis is decreased and the high-density lipoprotein present is less capable of reducing inflammation. Activation of neutrophils favors lipoprotein oxidation. Surprisingly, while obesity is associated with cytokine production in patients without renal failure, as well as among dialysis patients, increased body mass index, whether reflecting muscle mass or adipose tissue, is associated with a decline in mortality rates.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 51-55 |
| Number of pages | 5 |
| Journal | Blood Purification |
| Volume | 24 |
| Issue number | 1 |
| DOIs | |
| State | Published - Dec 2006 |
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Keywords
- High-density lipoprotein
- Sarcopenia
- Vascular endothelium
ASJC Scopus subject areas
- Nephrology
- Hematology
Cite this
Association between inflammation and malnutrition as risk factors of cardiovascular disease. / Kaysen, George.
In: Blood Purification, Vol. 24, No. 1, 12.2006, p. 51-55.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between inflammation and malnutrition as risk factors of cardiovascular disease
AU - Kaysen, George
PY - 2006/12
Y1 - 2006/12
N2 - Cardiovascular disease is the leading cause of death among dialysis patients. The relative risk of mortality increases as serum albumin concentration and body mass index decline. While these are generally associated with nutritional status, inflammation causes sarcopenia and decreased albumin concentration by reducing synthesis of proteins and increasing their catabolic rate. While inflammation can arise from atherosclerotic blood vessels, systemic inflammation from any source can alter the vascular endothelium and plasma protein composition in ways that promotes vascular injury. High-density lipoprotein synthesis is decreased and the high-density lipoprotein present is less capable of reducing inflammation. Activation of neutrophils favors lipoprotein oxidation. Surprisingly, while obesity is associated with cytokine production in patients without renal failure, as well as among dialysis patients, increased body mass index, whether reflecting muscle mass or adipose tissue, is associated with a decline in mortality rates.
AB - Cardiovascular disease is the leading cause of death among dialysis patients. The relative risk of mortality increases as serum albumin concentration and body mass index decline. While these are generally associated with nutritional status, inflammation causes sarcopenia and decreased albumin concentration by reducing synthesis of proteins and increasing their catabolic rate. While inflammation can arise from atherosclerotic blood vessels, systemic inflammation from any source can alter the vascular endothelium and plasma protein composition in ways that promotes vascular injury. High-density lipoprotein synthesis is decreased and the high-density lipoprotein present is less capable of reducing inflammation. Activation of neutrophils favors lipoprotein oxidation. Surprisingly, while obesity is associated with cytokine production in patients without renal failure, as well as among dialysis patients, increased body mass index, whether reflecting muscle mass or adipose tissue, is associated with a decline in mortality rates.
KW - High-density lipoprotein
KW - Sarcopenia
KW - Vascular endothelium
UR - http://www.scopus.com/inward/record.url?scp=29244460658&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=29244460658&partnerID=8YFLogxK
U2 - 10.1159/000089437
DO - 10.1159/000089437
M3 - Article
C2 - 16361841
AN - SCOPUS:29244460658
VL - 24
SP - 51
EP - 55
JO - Blood Purification
JF - Blood Purification
SN - 0253-5068
IS - 1
ER -