Association between hyperglycemia and survival in 228 horses with acute gastrointestinal disease

D. M. Hassel, Ashley E Hill, R. A. Rorabeck

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


Background: Glucose homeostasis is dysregulated in critically ill humans resulting in hyperglycemia and decreased survival. Hyperglycemia is common in horses presenting with abdominal crisis, and this might be associated with a worse prognosis for survival. Objective: To determine if hyperglycemia in horses with acute abdominal disease is associated with increased odds of failure to survive to hospital discharge. Animals: Two hundred and twenty-eight adult horses with acute gastrointestinal disease. Methods: Observational retrospective study. Records of horses > 1 year of age presenting for treatment of colic over a 3-year period were reviewed. Data collected included age, duration of colic, glucose, heart rate, PCV, total protein, anion gap, cost of hospitalization, breed, sex, pain at admission, diagnosis, whether surgery was performed, and life status at hospital discharge. Potential risk factors for nonsurvival were screened by univariable logistic regression and the best-fitting univariable model was used as the basis for multivariable regression modeling. Results: Mean blood glucose was 155mg/dL (8.5mM) with 45% of the population above the reference range; 16.7% (38 of 228) of horses had severe hyperglycemia (> 195mg/dL; 10.7mM). Factors associated with increased odds of failure to survive included glucose, severity of pain at admission, heart rate, PCV, anion gap, and diagnosis. The best-fitting multivariable model included glucose and diagnosis, with age included as a confounding variable. The model correctly classified outcome for 92.5% of horses. Conclusions and Clinical Importance: This study has confirmed prior reports that hyperglycemia is common in horses with colic and is associated with a worse prognosis for survival to hospital discharge.

Original languageEnglish (US)
Pages (from-to)1261-1265
Number of pages5
JournalJournal of Veterinary Internal Medicine
Issue number6
StatePublished - Nov 2009
Externally publishedYes


  • Colic
  • Equine
  • Glucose
  • Prognosis
  • Risk factors

ASJC Scopus subject areas

  • veterinary(all)


Dive into the research topics of 'Association between hyperglycemia and survival in 228 horses with acute gastrointestinal disease'. Together they form a unique fingerprint.

Cite this