Association between embB codon 306 mutations and drug resistance in Mycobacterium tuberculosis

Xin Shen, Guo Miao Shen, Jie Wu, Xiao Hong Gui, Xia Li, Jian Mei, Kathryn DeRiemer, Qian Gao

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37 Scopus citations

Abstract

embB306 mutants were detected in both ethambutol (EMB)-resistant and EMB-susceptible strains of Mycobacterium tuberculosis. Multidrug-resistant (MDR) strains had a higher proportion of embB306 mutants than non-MDR strains (odds ratio, 6.78; P < 0.001). The embB306 locus is a candidate marker for rapid detection of MDR and extremely drug resistant tuberculosis.

Original languageEnglish (US)
Pages (from-to)2618-2620
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume51
Issue number7
DOIs
StatePublished - Jul 2007

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ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Shen, X., Shen, G. M., Wu, J., Gui, X. H., Li, X., Mei, J., DeRiemer, K., & Gao, Q. (2007). Association between embB codon 306 mutations and drug resistance in Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy, 51(7), 2618-2620. https://doi.org/10.1128/AAC.01516-06