Association between embB codon 306 mutations and drug resistance in Mycobacterium tuberculosis

Xin Shen, Guo Miao Shen, Jie Wu, Xiao Hong Gui, Xia Li, Jian Mei, Kathryn DeRiemer, Qian Gao

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

embB306 mutants were detected in both ethambutol (EMB)-resistant and EMB-susceptible strains of Mycobacterium tuberculosis. Multidrug-resistant (MDR) strains had a higher proportion of embB306 mutants than non-MDR strains (odds ratio, 6.78; P < 0.001). The embB306 locus is a candidate marker for rapid detection of MDR and extremely drug resistant tuberculosis.

Original languageEnglish (US)
Pages (from-to)2618-2620
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume51
Issue number7
DOIs
StatePublished - Jul 2007

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Ethambutol
Mycobacterium tuberculosis
Drug Resistance
Codon
Extensively Drug-Resistant Tuberculosis
Mutation
Odds Ratio

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Association between embB codon 306 mutations and drug resistance in Mycobacterium tuberculosis. / Shen, Xin; Shen, Guo Miao; Wu, Jie; Gui, Xiao Hong; Li, Xia; Mei, Jian; DeRiemer, Kathryn; Gao, Qian.

In: Antimicrobial Agents and Chemotherapy, Vol. 51, No. 7, 07.2007, p. 2618-2620.

Research output: Contribution to journalArticle

Shen, X, Shen, GM, Wu, J, Gui, XH, Li, X, Mei, J, DeRiemer, K & Gao, Q 2007, 'Association between embB codon 306 mutations and drug resistance in Mycobacterium tuberculosis', Antimicrobial Agents and Chemotherapy, vol. 51, no. 7, pp. 2618-2620. https://doi.org/10.1128/AAC.01516-06
Shen, Xin ; Shen, Guo Miao ; Wu, Jie ; Gui, Xiao Hong ; Li, Xia ; Mei, Jian ; DeRiemer, Kathryn ; Gao, Qian. / Association between embB codon 306 mutations and drug resistance in Mycobacterium tuberculosis. In: Antimicrobial Agents and Chemotherapy. 2007 ; Vol. 51, No. 7. pp. 2618-2620.
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