Association between Diabetes Mellitus, Hypothyroidism or Hyperadrenocorticism, and Atherosclerosis in Dogs

Rebecka S. Hess, Philip H Kass, Thomas J. Van Winkle

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

The objective of this study was to determine whether dogs with atherosclerosis are more likely to have concurrent diabetes mellitus, hypothyroidism, or hyperadrenocorticism than dogs that do not have atherosclerosis. A retrospective mortality prevalence case-control study was performed. The study group included 30 dogs with histopathological evidence of atherosclerosis. The control group included 142 dogs with results of a complete postmortem examination, a final postmortem examination diagnosis of neoplasia, and no histopathological evidence of atherosclerosis. Control dogs were frequency matched for age and year in which the postmortem examination was performed. Proportionate changes in the prevalence of diabetes mellitus, hypothyroidism, and hyperadrenocorticism were calculated by exact prevalence odds ratios (POR), 95% confidence intervals (95% CI), and P values. Multiple logistic regression analysis was used to examine the combined effects of prevalence determinants while controlling for age and year of postmortem examination. Dogs with atherosclerosis were over 53 times more likely to have concurrent diabetes mellitus than dogs without atherosclerosis (POR = 53.6; 95% CI, 4.6-627.5; P = .002) and over 51 times more likely to have concurrent hypothyroidism than dogs without atherosclerosis (POR = 51.1; 95% CI, 14.5-180.1; P < .001). Dogs with atherosclerosis were not found to be more likely to have concurrent hyperadrenocorticism than dogs that did not have atherosclerosis (POR = 1.8; 95% CI, 0.2-17.6; P = .59). Diabetes mellitus and hypothyroidism, but not hyperadrenocorticism, are more prevalent in dogs with atherosclerosis compared to dogs without atherosclerosis on postmortem examination.

Original languageEnglish (US)
Pages (from-to)489-494
Number of pages6
JournalJournal of Veterinary Internal Medicine
Volume17
Issue number4
DOIs
StatePublished - Jul 2003

Fingerprint

Adrenocortical Hyperfunction
hyperadrenocorticism
hypothyroidism
diabetes mellitus
Hypothyroidism
atherosclerosis
Atherosclerosis
Diabetes Mellitus
Dogs
dogs
Autopsy
necropsy
odds ratio
confidence interval
Odds Ratio
Confidence Intervals
case-control studies
Case-Control Studies

Keywords

  • Canine
  • Endocrinopathy
  • Lipid disorders
  • Pancreas
  • Thyroid

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Association between Diabetes Mellitus, Hypothyroidism or Hyperadrenocorticism, and Atherosclerosis in Dogs. / Hess, Rebecka S.; Kass, Philip H; Van Winkle, Thomas J.

In: Journal of Veterinary Internal Medicine, Vol. 17, No. 4, 07.2003, p. 489-494.

Research output: Contribution to journalArticle

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