Association between cholesterol exposure and neuropathological findings: The ACT study

Brianne M. Bettcher, M. Colin Ard, Bruce R Reed, Andreana Benitez, Amanda Simmons, Eric B. Larson, Josh A. Sonnen, Thomas J. Montine, Ge Li, C. Dirk Keene, Paul K. Crane, Dan M Mungas

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We characterized the relationship between late life cholesterol exposure and neuropathological outcomes in a community-based, older adult cohort. Adult Changes in Thought (ACT) is a cohort study that enrolls consenting, randomly selected, non-demented people aged ≥65 from a healthcare delivery system. We used late life HDL and total cholesterol lab values from Group Health computerized records, and calculated HDL and non-HDL levels. We evaluated neuropathological outcomes of Alzheimer's disease, cerebral amyloid angiopathy, vascular brain injury, and Lewy body disease. Using linear mixed models with age and antilipemic medication as predictors, we obtained predicted cholesterol values at age 70 and 10 years prior to death for individuals with available cholesterol data in 10-year exposure windows. We used logistic regression to determine whether predicted late life cholesterol levels were associated with neuropathological outcomes controlling for age at death, APOE genotype, sex, and their interactions with cholesterol levels. 525 decedents came to autopsy by 08/2014. Of these, plasma cholesterol concentration was available for 318 (age 70, model 1) and 396 (10 years prior to death, model 2) participants. We did not find associations between late life cholesterol and Alzheimer's disease neuropathological changes, and there were no associations between cholesterol levels and amyloid angiopathy or vascular brain injury. We observed an association between predicted non-HDL cholesterol at age 70 and Lewy body disease. Our study suggests an association between late life non-HDL cholesterol exposure and Lewy body disease. We did not observe associations between late life cholesterol levels and Braak stage or CERAD score.

Original languageEnglish (US)
Pages (from-to)1307-1315
Number of pages9
JournalJournal of Alzheimer's Disease
Volume59
Issue number4
DOIs
StatePublished - 2017

Fingerprint

Cholesterol
Lewy Body Disease
Cerebrovascular Trauma
Alzheimer Disease
Cerebral Amyloid Angiopathy
Delivery of Health Care
Hypolipidemic Agents
HDL Cholesterol
Autopsy
Linear Models
Cohort Studies
Logistic Models
Genotype
Health

Keywords

  • Alzheimer's disease
  • epidemiology
  • Lewy body
  • lipids
  • neuropathology
  • vascular

ASJC Scopus subject areas

  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Association between cholesterol exposure and neuropathological findings : The ACT study. / Bettcher, Brianne M.; Ard, M. Colin; Reed, Bruce R; Benitez, Andreana; Simmons, Amanda; Larson, Eric B.; Sonnen, Josh A.; Montine, Thomas J.; Li, Ge; Keene, C. Dirk; Crane, Paul K.; Mungas, Dan M.

In: Journal of Alzheimer's Disease, Vol. 59, No. 4, 2017, p. 1307-1315.

Research output: Contribution to journalArticle

Bettcher, BM, Ard, MC, Reed, BR, Benitez, A, Simmons, A, Larson, EB, Sonnen, JA, Montine, TJ, Li, G, Keene, CD, Crane, PK & Mungas, DM 2017, 'Association between cholesterol exposure and neuropathological findings: The ACT study', Journal of Alzheimer's Disease, vol. 59, no. 4, pp. 1307-1315. https://doi.org/10.3233/JAD-161224
Bettcher, Brianne M. ; Ard, M. Colin ; Reed, Bruce R ; Benitez, Andreana ; Simmons, Amanda ; Larson, Eric B. ; Sonnen, Josh A. ; Montine, Thomas J. ; Li, Ge ; Keene, C. Dirk ; Crane, Paul K. ; Mungas, Dan M. / Association between cholesterol exposure and neuropathological findings : The ACT study. In: Journal of Alzheimer's Disease. 2017 ; Vol. 59, No. 4. pp. 1307-1315.
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