Association between air pollution and lung function growth in Southern California children: Results from a second cohort

W. James Gauderman, G. Frank Gilliland, Hita Vora, Edward Avol, Daniel Stram, Rob McConnell, Duncan Thomas, Fred Lurmann, Helene G Margolis, Edward B. Rappaport, Kiros Berhane, John M. Peters

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Abstract

A cohort of 1,678 Southern California children, enrolled as fourth graders in 1996, was followed for 4 years to determine whether the growth in lung function of the children was associated with their exposure to ambient air pollutants. These subjects comprised the second cohort of fourth grade children participating in the Children's Health Study. Significant deficits in lung function growth rate were associated with exposure to acid vapor, NO 2, particles with aerodynamic diameter less than 2.5 μm (PM 2.5), and elemental carbon. For example, the average annual growth rates of maximal midexpiratory flow and forced expiratory volume in 1 second were reduced by approximately 11% (p = 0.005) and 5% (p = 0.03), respectively, across the observed range of acid exposure. Exposure to acid vapor was also associated with reductions in the ratio of maximal midexpiratory flow to forced vital capacity (p = 0.02), whereas exposure to ozone was correlated with reduced growth in peak flow rate (p = 0.006). Larger deficits in lung function growth rate were observed in children who reported spending more time outdoors. These findings provide important replication of our previous findings of an effect of air pollution on lung function growth that were based on the first fourth-grade cohort from the Children's Health Study.

Original languageEnglish (US)
Pages (from-to)76-84
Number of pages9
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume166
Issue number1
DOIs
StatePublished - Jul 1 2002

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Keywords

  • Air pollution
  • Children
  • Lung function growth

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

James Gauderman, W., Frank Gilliland, G., Vora, H., Avol, E., Stram, D., McConnell, R., Thomas, D., Lurmann, F., Margolis, H. G., Rappaport, E. B., Berhane, K., & Peters, J. M. (2002). Association between air pollution and lung function growth in Southern California children: Results from a second cohort. American Journal of Respiratory and Critical Care Medicine, 166(1), 76-84. https://doi.org/10.1164/rccm.2111021