Abstract
A cohort of 1,678 Southern California children, enrolled as fourth graders in 1996, was followed for 4 years to determine whether the growth in lung function of the children was associated with their exposure to ambient air pollutants. These subjects comprised the second cohort of fourth grade children participating in the Children's Health Study. Significant deficits in lung function growth rate were associated with exposure to acid vapor, NO 2, particles with aerodynamic diameter less than 2.5 μm (PM 2.5), and elemental carbon. For example, the average annual growth rates of maximal midexpiratory flow and forced expiratory volume in 1 second were reduced by approximately 11% (p = 0.005) and 5% (p = 0.03), respectively, across the observed range of acid exposure. Exposure to acid vapor was also associated with reductions in the ratio of maximal midexpiratory flow to forced vital capacity (p = 0.02), whereas exposure to ozone was correlated with reduced growth in peak flow rate (p = 0.006). Larger deficits in lung function growth rate were observed in children who reported spending more time outdoors. These findings provide important replication of our previous findings of an effect of air pollution on lung function growth that were based on the first fourth-grade cohort from the Children's Health Study.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 76-84 |
| Number of pages | 9 |
| Journal | American Journal of Respiratory and Critical Care Medicine |
| Volume | 166 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 1 2002 |
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Keywords
- Air pollution
- Children
- Lung function growth
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Association between air pollution and lung function growth in Southern California children : Results from a second cohort. / James Gauderman, W.; Frank Gilliland, G.; Vora, Hita; Avol, Edward; Stram, Daniel; McConnell, Rob; Thomas, Duncan; Lurmann, Fred; Margolis, Helene G; Rappaport, Edward B.; Berhane, Kiros; Peters, John M.
In: American Journal of Respiratory and Critical Care Medicine, Vol. 166, No. 1, 01.07.2002, p. 76-84.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between air pollution and lung function growth in Southern California children
T2 - Results from a second cohort
AU - James Gauderman, W.
AU - Frank Gilliland, G.
AU - Vora, Hita
AU - Avol, Edward
AU - Stram, Daniel
AU - McConnell, Rob
AU - Thomas, Duncan
AU - Lurmann, Fred
AU - Margolis, Helene G
AU - Rappaport, Edward B.
AU - Berhane, Kiros
AU - Peters, John M.
PY - 2002/7/1
Y1 - 2002/7/1
N2 - A cohort of 1,678 Southern California children, enrolled as fourth graders in 1996, was followed for 4 years to determine whether the growth in lung function of the children was associated with their exposure to ambient air pollutants. These subjects comprised the second cohort of fourth grade children participating in the Children's Health Study. Significant deficits in lung function growth rate were associated with exposure to acid vapor, NO 2, particles with aerodynamic diameter less than 2.5 μm (PM 2.5), and elemental carbon. For example, the average annual growth rates of maximal midexpiratory flow and forced expiratory volume in 1 second were reduced by approximately 11% (p = 0.005) and 5% (p = 0.03), respectively, across the observed range of acid exposure. Exposure to acid vapor was also associated with reductions in the ratio of maximal midexpiratory flow to forced vital capacity (p = 0.02), whereas exposure to ozone was correlated with reduced growth in peak flow rate (p = 0.006). Larger deficits in lung function growth rate were observed in children who reported spending more time outdoors. These findings provide important replication of our previous findings of an effect of air pollution on lung function growth that were based on the first fourth-grade cohort from the Children's Health Study.
AB - A cohort of 1,678 Southern California children, enrolled as fourth graders in 1996, was followed for 4 years to determine whether the growth in lung function of the children was associated with their exposure to ambient air pollutants. These subjects comprised the second cohort of fourth grade children participating in the Children's Health Study. Significant deficits in lung function growth rate were associated with exposure to acid vapor, NO 2, particles with aerodynamic diameter less than 2.5 μm (PM 2.5), and elemental carbon. For example, the average annual growth rates of maximal midexpiratory flow and forced expiratory volume in 1 second were reduced by approximately 11% (p = 0.005) and 5% (p = 0.03), respectively, across the observed range of acid exposure. Exposure to acid vapor was also associated with reductions in the ratio of maximal midexpiratory flow to forced vital capacity (p = 0.02), whereas exposure to ozone was correlated with reduced growth in peak flow rate (p = 0.006). Larger deficits in lung function growth rate were observed in children who reported spending more time outdoors. These findings provide important replication of our previous findings of an effect of air pollution on lung function growth that were based on the first fourth-grade cohort from the Children's Health Study.
KW - Air pollution
KW - Children
KW - Lung function growth
UR - http://www.scopus.com/inward/record.url?scp=0036644646&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036644646&partnerID=8YFLogxK
U2 - 10.1164/rccm.2111021
DO - 10.1164/rccm.2111021
M3 - Article
C2 - 12091175
AN - SCOPUS:0036644646
VL - 166
SP - 76
EP - 84
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
SN - 1073-449X
IS - 1
ER -