Abstract
Average growth of lung function over a 4-yr period, in three cohorts of southern California children who were in the fourth, seventh, or tenth grade in 1993, was modeled as a function of average exposure to ambient air pollutants. In the fourth-grade cohort, significant deficits in growth of lung function (FEV1, FVC, maximal midexpiratory flow [MMEF], and FEF75) were associated with exposure to particles with aerodynamic diameter less than 10 μm (PM10), PM2.5, PM10-PM2.5, NO2, and inorganic acid vapor (p < 0.05). No significant associations were observed with ozone. The estimated growth rate for children in the most polluted of the communities as compared with the least polluted was predicted to result in a cumulative reduction of 3.4% in FEV1 and 5.0% in MMEF over the 4-yr study period. The estimated deficits were generally larger for children spending more time outdoors. In the seventh- and tenth-grade cohorts, the estimated pollutant effects were also negative for most lung function measures, but sample sizes were lower in these groups and none achieved statistical significance. The results suggest that significant negative effects on lung function growth in children occur at current ambient concentrations of particles, NO2, and inorganic acid vapor.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1383-1390 |
| Number of pages | 8 |
| Journal | American Journal of Respiratory and Critical Care Medicine |
| Volume | 162 |
| Issue number | 4 I |
| State | Published - 2000 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Association between air pollution and lung function growth in southern California children. / Gauderman, W. J.; McConnell, R.; Gilliland, F.; London, S.; Thomas, D.; Avol, E.; Vora, H.; Berhane, K.; Rappaport, E. B.; Lurmann, F.; Margolis, Helene G; Peters, J.
In: American Journal of Respiratory and Critical Care Medicine, Vol. 162, No. 4 I, 2000, p. 1383-1390.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between air pollution and lung function growth in southern California children
AU - Gauderman, W. J.
AU - McConnell, R.
AU - Gilliland, F.
AU - London, S.
AU - Thomas, D.
AU - Avol, E.
AU - Vora, H.
AU - Berhane, K.
AU - Rappaport, E. B.
AU - Lurmann, F.
AU - Margolis, Helene G
AU - Peters, J.
PY - 2000
Y1 - 2000
N2 - Average growth of lung function over a 4-yr period, in three cohorts of southern California children who were in the fourth, seventh, or tenth grade in 1993, was modeled as a function of average exposure to ambient air pollutants. In the fourth-grade cohort, significant deficits in growth of lung function (FEV1, FVC, maximal midexpiratory flow [MMEF], and FEF75) were associated with exposure to particles with aerodynamic diameter less than 10 μm (PM10), PM2.5, PM10-PM2.5, NO2, and inorganic acid vapor (p < 0.05). No significant associations were observed with ozone. The estimated growth rate for children in the most polluted of the communities as compared with the least polluted was predicted to result in a cumulative reduction of 3.4% in FEV1 and 5.0% in MMEF over the 4-yr study period. The estimated deficits were generally larger for children spending more time outdoors. In the seventh- and tenth-grade cohorts, the estimated pollutant effects were also negative for most lung function measures, but sample sizes were lower in these groups and none achieved statistical significance. The results suggest that significant negative effects on lung function growth in children occur at current ambient concentrations of particles, NO2, and inorganic acid vapor.
AB - Average growth of lung function over a 4-yr period, in three cohorts of southern California children who were in the fourth, seventh, or tenth grade in 1993, was modeled as a function of average exposure to ambient air pollutants. In the fourth-grade cohort, significant deficits in growth of lung function (FEV1, FVC, maximal midexpiratory flow [MMEF], and FEF75) were associated with exposure to particles with aerodynamic diameter less than 10 μm (PM10), PM2.5, PM10-PM2.5, NO2, and inorganic acid vapor (p < 0.05). No significant associations were observed with ozone. The estimated growth rate for children in the most polluted of the communities as compared with the least polluted was predicted to result in a cumulative reduction of 3.4% in FEV1 and 5.0% in MMEF over the 4-yr study period. The estimated deficits were generally larger for children spending more time outdoors. In the seventh- and tenth-grade cohorts, the estimated pollutant effects were also negative for most lung function measures, but sample sizes were lower in these groups and none achieved statistical significance. The results suggest that significant negative effects on lung function growth in children occur at current ambient concentrations of particles, NO2, and inorganic acid vapor.
UR - http://www.scopus.com/inward/record.url?scp=0033769727&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033769727&partnerID=8YFLogxK
M3 - Article
C2 - 11029349
AN - SCOPUS:0033769727
VL - 162
SP - 1383
EP - 1390
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
SN - 1073-449X
IS - 4 I
ER -