Association analysis between canine behavioural traits and genetic polymorphisms in the Shiba Inu breed

Y. Takeuchi, F. Kaneko, C. Hashizume, K. Masuda, N. Ogata, T. Maki, M. Inoue-Murayama, Benjamin Hart, Y. Mori

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Summary The relationships between behavioural trait data and the genotype of 15 polymorphisms in eight neurotransmitter-related genes were analysed in 77 dogs of the Shiba Inu breed, an indigenous Japanese dog. The data were obtained from a 26-item questionnaire on the dog's behaviour, distributed to the dog's owners, through veterinary hospitals and the Shiba Inu breed magazine. A factor analysis of the questionnaire items extracted eight factors accounting for 66.8% of the variance. An association analysis between these factors and genetic polymorphisms indicated that the polymorphism of c.471T>C in the solute carrier family 1 (neuronal/epithelial high-affinity glutamate transporter) member 2 (SLC1A2) gene was significantly associated with Factor 1, referred to as 'aggression to strangers'. This association remained stable in separate analyses of data from surveys obtained from the hospitals and those obtained from the magazine. The results suggest that the c.471T>C polymorphism is associated with some types of aggressive behaviour in the Shiba Inu. Further studies using other dog breeds are necessary to extend these findings to dogs in general.

Original languageEnglish (US)
Pages (from-to)616-622
Number of pages7
JournalAnimal Genetics
Volume40
Issue number5
DOIs
StatePublished - Oct 1 2009

Fingerprint

Behavioral Genetics
Genetic Polymorphisms
Canidae
genetic polymorphism
Dogs
breeds
dogs
aggression
questionnaires
Statistical Factor Analysis
Animal Hospitals
veterinary clinics
Amino Acid Transport System X-AG
dog breeds
neurotransmitters
glutamates
solutes
transporters
Aggression
genes

Keywords

  • Aggression
  • Canine behaviour
  • Dogs
  • Genetic polymorphism
  • Questionnaire survey
  • SLC1A2 gene
  • Temperament

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Genetics

Cite this

Takeuchi, Y., Kaneko, F., Hashizume, C., Masuda, K., Ogata, N., Maki, T., ... Mori, Y. (2009). Association analysis between canine behavioural traits and genetic polymorphisms in the Shiba Inu breed. Animal Genetics, 40(5), 616-622. https://doi.org/10.1111/j.1365-2052.2009.01888.x

Association analysis between canine behavioural traits and genetic polymorphisms in the Shiba Inu breed. / Takeuchi, Y.; Kaneko, F.; Hashizume, C.; Masuda, K.; Ogata, N.; Maki, T.; Inoue-Murayama, M.; Hart, Benjamin; Mori, Y.

In: Animal Genetics, Vol. 40, No. 5, 01.10.2009, p. 616-622.

Research output: Contribution to journalArticle

Takeuchi, Y, Kaneko, F, Hashizume, C, Masuda, K, Ogata, N, Maki, T, Inoue-Murayama, M, Hart, B & Mori, Y 2009, 'Association analysis between canine behavioural traits and genetic polymorphisms in the Shiba Inu breed', Animal Genetics, vol. 40, no. 5, pp. 616-622. https://doi.org/10.1111/j.1365-2052.2009.01888.x
Takeuchi, Y. ; Kaneko, F. ; Hashizume, C. ; Masuda, K. ; Ogata, N. ; Maki, T. ; Inoue-Murayama, M. ; Hart, Benjamin ; Mori, Y. / Association analysis between canine behavioural traits and genetic polymorphisms in the Shiba Inu breed. In: Animal Genetics. 2009 ; Vol. 40, No. 5. pp. 616-622.
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