Assessment of whole-brain vasodilatory capacity with acetazolamide challenge at 1.5 T using dynamic contrast imaging with frequency-shifted burst

Jeffrey R. Petrella, Charles DeCarli, Mandeep Dagli, Josef H. Duyn, Cécile B. Grandin, Joseph A. Frank, Elizabeth A. Hoffman, William H. Theodore

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19 Scopus citations

Abstract

PURPOSE: To determine whether whole-brain acetazolamide-induced changes in regional cerebral blood volume (rCBV) can be assessed on a conventional gradient 1.5-T MR system using 3-D dynamic susceptibility contrast-enhanced MR imaging. METHODS: A 3-D frequency-shifted (FS) burst technique was used to assess the intravascular first pass of contrast agent. Changes in rCBV were calculated in 40 volunteers before and after acetazolamide (n = 30) or saline (n = 10) injection using customized analysis software on an independent workstation. A single-section gradient-echo technique with better spatial resolution was used in one additional volunteer to examine the effect of partial volume averaging on calculation of absolute rCBV. RESULTS: A statistically significant increase in rCBV (gray matter = 23%, white matter = 32.5%) was noted after acetazolamide compared with saline. Baseline fractional CBVs were 22% ± 3% for gray matter and 12% ± 2% for white matter. Partial volume averaging was probably responsible for a systematic but linear overestimation of absolute rCBV. CONCLUSION: Acetazolamide-induced changes in rCBV can be assessed using 3-D dynamic susceptibility contrast- enhanced MR imaging with FS-burst on a conventional gradient 1.5-T MR system. Values obtained with this technique overestimate absolute rCBV but are systematically biased and can be used for intrasubject and intrasubject ratio comparisons.

Original languageEnglish (US)
Pages (from-to)1153-1161
Number of pages9
JournalAmerican Journal of Neuroradiology
Volume18
Issue number6
StatePublished - Jun 1997
Externally publishedYes

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Keywords

  • Blood, volume
  • Brain, magnetic resonance
  • Magnetic resonance, technique

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Petrella, J. R., DeCarli, C., Dagli, M., Duyn, J. H., Grandin, C. B., Frank, J. A., Hoffman, E. A., & Theodore, W. H. (1997). Assessment of whole-brain vasodilatory capacity with acetazolamide challenge at 1.5 T using dynamic contrast imaging with frequency-shifted burst. American Journal of Neuroradiology, 18(6), 1153-1161.