Assessment of whole-brain vasodilatory capacity with acetazolamide challenge at 1.5 T using dynamic contrast imaging with frequency-shifted burst

Jeffrey R. Petrella, Charles DeCarli, Mandeep Dagli, Josef H. Duyn, Cécile B. Grandin, Joseph A. Frank, Elizabeth A. Hoffman, William H. Theodore

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

PURPOSE: To determine whether whole-brain acetazolamide-induced changes in regional cerebral blood volume (rCBV) can be assessed on a conventional gradient 1.5-T MR system using 3-D dynamic susceptibility contrast-enhanced MR imaging. METHODS: A 3-D frequency-shifted (FS) burst technique was used to assess the intravascular first pass of contrast agent. Changes in rCBV were calculated in 40 volunteers before and after acetazolamide (n = 30) or saline (n = 10) injection using customized analysis software on an independent workstation. A single-section gradient-echo technique with better spatial resolution was used in one additional volunteer to examine the effect of partial volume averaging on calculation of absolute rCBV. RESULTS: A statistically significant increase in rCBV (gray matter = 23%, white matter = 32.5%) was noted after acetazolamide compared with saline. Baseline fractional CBVs were 22% ± 3% for gray matter and 12% ± 2% for white matter. Partial volume averaging was probably responsible for a systematic but linear overestimation of absolute rCBV. CONCLUSION: Acetazolamide-induced changes in rCBV can be assessed using 3-D dynamic susceptibility contrast- enhanced MR imaging with FS-burst on a conventional gradient 1.5-T MR system. Values obtained with this technique overestimate absolute rCBV but are systematically biased and can be used for intrasubject and intrasubject ratio comparisons.

Original languageEnglish (US)
Pages (from-to)1153-1161
Number of pages9
JournalAmerican Journal of Neuroradiology
Volume18
Issue number6
StatePublished - Jun 1997
Externally publishedYes

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Acetazolamide
Brain
Volunteers
Cerebral Blood Volume
Contrast Media
Software
Injections

Keywords

  • Blood, volume
  • Brain, magnetic resonance
  • Magnetic resonance, technique

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Assessment of whole-brain vasodilatory capacity with acetazolamide challenge at 1.5 T using dynamic contrast imaging with frequency-shifted burst. / Petrella, Jeffrey R.; DeCarli, Charles; Dagli, Mandeep; Duyn, Josef H.; Grandin, Cécile B.; Frank, Joseph A.; Hoffman, Elizabeth A.; Theodore, William H.

In: American Journal of Neuroradiology, Vol. 18, No. 6, 06.1997, p. 1153-1161.

Research output: Contribution to journalArticle

Petrella, Jeffrey R. ; DeCarli, Charles ; Dagli, Mandeep ; Duyn, Josef H. ; Grandin, Cécile B. ; Frank, Joseph A. ; Hoffman, Elizabeth A. ; Theodore, William H. / Assessment of whole-brain vasodilatory capacity with acetazolamide challenge at 1.5 T using dynamic contrast imaging with frequency-shifted burst. In: American Journal of Neuroradiology. 1997 ; Vol. 18, No. 6. pp. 1153-1161.
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title = "Assessment of whole-brain vasodilatory capacity with acetazolamide challenge at 1.5 T using dynamic contrast imaging with frequency-shifted burst",
abstract = "PURPOSE: To determine whether whole-brain acetazolamide-induced changes in regional cerebral blood volume (rCBV) can be assessed on a conventional gradient 1.5-T MR system using 3-D dynamic susceptibility contrast-enhanced MR imaging. METHODS: A 3-D frequency-shifted (FS) burst technique was used to assess the intravascular first pass of contrast agent. Changes in rCBV were calculated in 40 volunteers before and after acetazolamide (n = 30) or saline (n = 10) injection using customized analysis software on an independent workstation. A single-section gradient-echo technique with better spatial resolution was used in one additional volunteer to examine the effect of partial volume averaging on calculation of absolute rCBV. RESULTS: A statistically significant increase in rCBV (gray matter = 23{\%}, white matter = 32.5{\%}) was noted after acetazolamide compared with saline. Baseline fractional CBVs were 22{\%} ± 3{\%} for gray matter and 12{\%} ± 2{\%} for white matter. Partial volume averaging was probably responsible for a systematic but linear overestimation of absolute rCBV. CONCLUSION: Acetazolamide-induced changes in rCBV can be assessed using 3-D dynamic susceptibility contrast- enhanced MR imaging with FS-burst on a conventional gradient 1.5-T MR system. Values obtained with this technique overestimate absolute rCBV but are systematically biased and can be used for intrasubject and intrasubject ratio comparisons.",
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AU - Duyn, Josef H.

AU - Grandin, Cécile B.

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AU - Hoffman, Elizabeth A.

AU - Theodore, William H.

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N2 - PURPOSE: To determine whether whole-brain acetazolamide-induced changes in regional cerebral blood volume (rCBV) can be assessed on a conventional gradient 1.5-T MR system using 3-D dynamic susceptibility contrast-enhanced MR imaging. METHODS: A 3-D frequency-shifted (FS) burst technique was used to assess the intravascular first pass of contrast agent. Changes in rCBV were calculated in 40 volunteers before and after acetazolamide (n = 30) or saline (n = 10) injection using customized analysis software on an independent workstation. A single-section gradient-echo technique with better spatial resolution was used in one additional volunteer to examine the effect of partial volume averaging on calculation of absolute rCBV. RESULTS: A statistically significant increase in rCBV (gray matter = 23%, white matter = 32.5%) was noted after acetazolamide compared with saline. Baseline fractional CBVs were 22% ± 3% for gray matter and 12% ± 2% for white matter. Partial volume averaging was probably responsible for a systematic but linear overestimation of absolute rCBV. CONCLUSION: Acetazolamide-induced changes in rCBV can be assessed using 3-D dynamic susceptibility contrast- enhanced MR imaging with FS-burst on a conventional gradient 1.5-T MR system. Values obtained with this technique overestimate absolute rCBV but are systematically biased and can be used for intrasubject and intrasubject ratio comparisons.

AB - PURPOSE: To determine whether whole-brain acetazolamide-induced changes in regional cerebral blood volume (rCBV) can be assessed on a conventional gradient 1.5-T MR system using 3-D dynamic susceptibility contrast-enhanced MR imaging. METHODS: A 3-D frequency-shifted (FS) burst technique was used to assess the intravascular first pass of contrast agent. Changes in rCBV were calculated in 40 volunteers before and after acetazolamide (n = 30) or saline (n = 10) injection using customized analysis software on an independent workstation. A single-section gradient-echo technique with better spatial resolution was used in one additional volunteer to examine the effect of partial volume averaging on calculation of absolute rCBV. RESULTS: A statistically significant increase in rCBV (gray matter = 23%, white matter = 32.5%) was noted after acetazolamide compared with saline. Baseline fractional CBVs were 22% ± 3% for gray matter and 12% ± 2% for white matter. Partial volume averaging was probably responsible for a systematic but linear overestimation of absolute rCBV. CONCLUSION: Acetazolamide-induced changes in rCBV can be assessed using 3-D dynamic susceptibility contrast- enhanced MR imaging with FS-burst on a conventional gradient 1.5-T MR system. Values obtained with this technique overestimate absolute rCBV but are systematically biased and can be used for intrasubject and intrasubject ratio comparisons.

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