Assessment of vitamin A status with the relative-dose-response test in Peruvian children recovering from pneumonia

Charles B. Stephensen, Luis Miguel Franchi, Herminio Hernandez, Miguel Campos, Ana Colarossi, Robert H. Gilman, Jose O. Alvarez

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Background: The relative-dose-response (RDR) test is used to identify subjects with marginal liver vitamin A stores, but its use has not been evaluated during episodes of infection. Objective: The objective was to assess, with the RDR test, the vitamin A status of children recovering from pneumonia. Design: As part of a double-blind, placebo-controlled clinical trial of high-dose vitamin A supplements among children hospitalized with pneumonia in Lima, Peru, we examined the association of treatment group, nutritional status, severity of disease, and induction of the acute phase response [on the basis of serum C-reactive protein (CRP)] on serum retinol and the RDR test. Results: Serum retinol was low at admission and increased significantly in both the vitamin A and placebo groups during recovery. Serum CRP had a significant, inverse association with retinol at both admission and discharge. Serum retinol and CRP concentrations never differed significantly between the treatment groups. Among subjects with CRP ≥ 10 mg/L, 21% in the vitamin A group and 20% in the placebo groups (P = 0.83) had a positive RDR test result. Among subjects with CRP < 10 mg/L, 56% in the placebo group but only 6% in the vitamin A group had positive RDR test results (P = 0.002). Conclusion: The RDR test was useful in assessing the vitamin A status of children recovering from pneumonia when CRP concentrations were < 10 mg/L but not when CRP concentrations were higher.

Original languageEnglish (US)
Pages (from-to)1351-1357
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume76
Issue number6
StatePublished - Dec 1 2002

Keywords

  • Acute phase response
  • C-reactive protein
  • Children
  • CRP
  • Peru
  • Pneumonia
  • RDR test
  • Relative-dose-response test
  • Retinol
  • Vitamin A

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

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    Stephensen, C. B., Franchi, L. M., Hernandez, H., Campos, M., Colarossi, A., Gilman, R. H., & Alvarez, J. O. (2002). Assessment of vitamin A status with the relative-dose-response test in Peruvian children recovering from pneumonia. American Journal of Clinical Nutrition, 76(6), 1351-1357.