Assessment of ventricular size and function in congenitally corrected transposition of the great arteries

Thomas P. Graham, Mark D Parrish, Robert J. Boucek, Robert C. Boerth, James A. Breitweser, Sandra Thompson, Rose M. Robertson, John R. Morgan, Gottlieb C. Friesinger

Research output: Contribution to journalArticle

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Abstract

Twenty-four quantitative cineangiographic studies were performed in 19 patients with congenitally corrected transposition of the great arteries to assess right and left ventricular size and function. Ages ranged from 7 days to 44 years and associated lesions included ventricular septal defect (13 of 19), pulmonary stenosis (9 of 19), and systemic (tricuspid) valvular insufficiency (7 of 19). Systemic (anatomically right) ventricular end-diastolic volume was within normal limits in most patients and averaged 119% of predicted normal. Pulmonary (anatomically left) ventricular end-diastolic volume also was normal in most patients, averaged 112% of predicted, and was not different from systemic (right) ventricular end-diastolic volume. Systemic ventricular ejection fraction (RVEF) averaged 0.61 ± 0.02 and was not different from pulmonary ventricular ejection fraction (LVEF) (0.65 ± 0.02), but important differences were apparent when age was considered. With exclusion of 2 patients with hypoplastic systemic ventricles and 2 studies performed <6 months after open heart surgery, all 12 patients aged <10 years had a normal RVEF, whereas 2 of 5 patients aged >17 years had a definitely low RVEF and 1 of 5 had a value at the lower limit of normal. In children, systemic and pulmonary ventricular pump function is usually normal in congenitally corrected transposition of the great arteries and any deviation from normal should suggest ventricular hypoplasia or an increase in afterload. After childhood, systemic ventricular dysfunction is more common and may reflect the inability of the anatomic right ventricle to function as the systemic pumping chamber over a normal lifetime in most patients with congenitally corrected transposition of the great arteries.

Original languageEnglish (US)
Pages (from-to)244-251
Number of pages8
JournalThe American journal of cardiology
Volume51
Issue number2
DOIs
StatePublished - Jan 15 1983
Externally publishedYes

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Ventricular Function
Stroke Volume
Lung
Ventricular Dysfunction
Pulmonary Valve Stenosis
Ventricular Heart Septal Defects
Left Ventricular Function
Heart Ventricles
Congenitally corrected transposition of the great arteries

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Assessment of ventricular size and function in congenitally corrected transposition of the great arteries. / Graham, Thomas P.; Parrish, Mark D; Boucek, Robert J.; Boerth, Robert C.; Breitweser, James A.; Thompson, Sandra; Robertson, Rose M.; Morgan, John R.; Friesinger, Gottlieb C.

In: The American journal of cardiology, Vol. 51, No. 2, 15.01.1983, p. 244-251.

Research output: Contribution to journalArticle

Graham, TP, Parrish, MD, Boucek, RJ, Boerth, RC, Breitweser, JA, Thompson, S, Robertson, RM, Morgan, JR & Friesinger, GC 1983, 'Assessment of ventricular size and function in congenitally corrected transposition of the great arteries', The American journal of cardiology, vol. 51, no. 2, pp. 244-251. https://doi.org/10.1016/S0002-9149(83)80043-5
Graham, Thomas P. ; Parrish, Mark D ; Boucek, Robert J. ; Boerth, Robert C. ; Breitweser, James A. ; Thompson, Sandra ; Robertson, Rose M. ; Morgan, John R. ; Friesinger, Gottlieb C. / Assessment of ventricular size and function in congenitally corrected transposition of the great arteries. In: The American journal of cardiology. 1983 ; Vol. 51, No. 2. pp. 244-251.
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